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Antioxidative, Anti-Inflammatory, and Anticancer Properties of the Red Biopigment Extract from Monascus purpureus (MTCC 369)

[Journal of Food Biochemistry] The Monascus purpureus (MTCC 369) extracted biopigment produced by solid-state fermentation was evaluated for its therapeutic potential using human prostate LNCaP cells.

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Nrf2 Antioxidant Pathway and Apoptosis Induction and Inhibition of NF-κB-Mediated Inflammatory Response in Human Prostate Cancer PC3 Cells by Brassica oleracea var. acephala: An...

[Molecular Biology Reports] Molecular changes due to the anticancer impact of Brassica oleracea var. acephala on PC3 were involved in the induction of Nrf2 antioxidant pathway and apoptosis and inhibition of inflammation.

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Application of Box-Behnken Design for Optimization of Phenolics Extraction from Leontodon hispidulus in Relation to Its Antioxidant, Anti-inflammatory and Cytotoxic Activities

[Scientific Reports] Antioxidant, anticancer and anti-inflammatory activities were evaluated by ABTS-assay, prostate and cervical carcinoma human cell lines and carrageenan-induced rat paw edema model, respectively.

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Targeting Dual-Specificity Tyrosine Phosphorylation-Regulated Kinase 2 with a Highly Selective Inhibitor for the Treatment of Prostate Cancer

[Nature Communications] Dual-specificity tyrosine phosphorylation-regulated kinase 2 (DYRK2) was found and confirmed to be highly expressed in the prostate cancer (PCa) tissues and cells, and knock-down of DYRK2 remarkably reduced PCa burden in vitro and in vivo.

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Long Non-coding RNA MIR22HG Suppresses Cell Proliferation and Promotes Apoptosis in Prostate Cancer Cells by Sponging microRNA-9-3p

[Bioengineered] MIR22HG and microRNA-9-3p expressions in prostate cancer cells were examined with the use of quantitative real-time PCR.

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Prostate Cancer Addiction to Oxidative Stress Defines Sensitivity to Anti-Tumor Neutrophils

[Clinical & Experimental Metastasis] Using pharmacologic reactive oxygen species (ROS) inhibitors and NADPH oxidase 2-null neutrophils, investigators found that ROS depletion specifically suppresses growth of androgen-insensitive prostate cancer cells.

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Aberrant PJA2-CHRM3 Signaling Creates a Therapeutic Vulnerability in Gastric Tumor

[British Journal of Cancer] Scientists constructed mouse gastric organoids to recapitulate the morphological and functional characteristics of diffuse-type gastric cancer for FDA-approved drug screening.

Damon Runyon Cancer Research Foundation Awards $4.8 Million to Exceptional Early-Career Scientists

[Damon Runyon Cancer Research Foundation] The Damon Runyon Cancer Research Foundation has named 16 new Damon Runyon Fellows. This fellowship encourages young scientists to pursue careers in cancer research by providing them with independent funding to investigate cancer causes, mechanisms, therapies, and prevention.

Tumor Transcriptome-Wide Expression Classifiers Predict Treatment Sensitivity in Advanced Prostate Cancers

[Cell] To identify novel biomarker-treatment pairings, researchers examined associations between biological pathways and 14-year survival outcomes of patients randomized in practice-changing Phase III trials. They included transcriptome-wide expression signatures and immunohistochemistry markers on prostate tumors from 1,523 patients.

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