Justin.choi

[Cancer Discovery] Scientists found that a combination of interferon alpha and anti-PD-1-based immunotherapy resulted in enhanced antitumor activity in unresectable hepatocellular carcinoma patients.

[Signal Transduction and Targeted Therapy] The authors present the intricate mechanisms through which dysregulated non-coding RNAs control resistance to the four major types of cancer therapies.

[Science Signaling] Exploiting the wide spectrum of diacylglycerol signals from an integrated perspective could underscore meaningful advances in targeted cancer therapy.

[BriaCell Therapeutics Corp.] BriaCell Therapeutics Corp., a clinical-stage biotechnology company specializing in targeted immunotherapies for cancer, announced that the US FDA has granted Fast Track status to BriaCell’s lead candidate, Bria-IMT™, for the treatment of metastatic breast cancer.

[Science Signaling] The authors found that cell fusion caused by the SARS-CoV-2 spike protein induced a type I interferon response and that that cell fusion damaged nuclei and resulted in the formation of micronuclei that were sensed by the cytosolic DNA sensor cGAS and led to the activation of its downstream effector STING.

[NPJ Biofilms and Microbiomes] Investigators found that human nasal commensal Staphylococcus epidermidis promoted protease–protease inhibitor balance in favor of the host and prevented influenza A virus replication in the nasal mucosa and lungs.