Noshin Noorjahan

[Discover Oncology] Scientists investigated the impact of Caspase-3 gene deletion on bone marrow-derived dendritic cells (BMDCs) and their anti-tumor functions. BMDCs were generated in vitro using GM-CSF and IL-4 from Caspase-3 knockout and heterozygous mouse progenitors.

[Immunologic Research] The authors compile current evidence regarding the involvement of macrophage-derived exosomes in autoimmune disorders such as rheumatoid arthritis and systemic lupus erythematosus, emphasizing their potential as both biomarkers and therapeutic agents.

[Astrazeneca] AstraZeneca’s Imfinzi in combination with standard-of-care fluorouracil, leucovorin, oxaliplatin, and docetaxel chemotherapy has been approved in the US for the treatment of adult patients with resectable, early-stage and locally advanced gastric and gastroesophageal junction cancers.

[NPJ Regenerative Medicine] Researchers evaluated ferrets exposed to a single dose of bleomycin longitudinally, and found sustained restrictive physiology, increased opacification and fibrotic injury in the lungs through 22 weeks.

[Scientific Reports] The authors investigated the roles of the transcription factor CEBPA and the sirtuin family protein SIRT4 in sepsis-induced acute lung injury through both cell-based experiments and animal models.

[npj Precision Oncology] Investigators reported that the epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) resistance mechanism is mediated by lysosome-related regulation.