Noshin Noorjahan

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Protein Kinase Cι Dictates Tumor Trajectory, Cell Plasticity, and Immune Surveillance in Lung Adenocarcinoma

[Cell Reports] Researchers demonstrated that genetic loss of protein kinase Cι alters the trajectory of mouse Kras/Trp53-driven lung adenocarcinoma tumors from one resembling lung development to one mimicking lung regeneration.

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SOS1 Inhibition Suppresses the Emergence of Osimertinib Resistance to Generate a Durable Response in EGFR-Mutant Lung Cancer

[Science Signaling] The authors found that inhibiting the proximal receptor tyrosine kinase signaling intermediate SOS1 promoted continued osimertinib efficacy in sensitive cells and restored sensitivity in cells with acquired resistance.

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A Positive Feedback Loop between TNS1 and ZEB1 Promotes TGFβ-induced Epithelial-to-Mesenchymal Transition in Lung Cancer

[Communications Biology] Researchers identified that tensin-1 (TNS1) is upregulated in a TGFβ-induced epithelial-mesenchymal transition cell model.

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Construction of the Cancer Cell Continuum Reveals Hybrid EMT State Driving Lung Adenocarcinoma Aggression

[Cancer Gene Therapy] Investigators reconstructed the epithelial-to-mesenchymal transition (EMT) spectrum in lung adenocarcinoma by integrating single-cell RNA sequencing data with advanced cell trajectory inference techniques.

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Applications and Complementarity of Organ-Chips and Animal Models in Lung Cancer Driver Gene Research

[Cell Biology International] The authors summarize and compare previous studies of the application and complementarity of organ-chip technologies and traditional animal models for investigating the same genetic alterations.

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FDA Approves First Cancer Drug Based on Broad Institute Science

[Broad Institute] The US FDA has approved sevabertinib, which was developed by Bayer Healthcare Pharmaceuticals in close collaboration with the Broad, and is the first FDA-approved medicine from the long-standing Broad-Bayer oncology research alliance.

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Chromatin Accessibility in Stem Cells Unveils Progressive Transcriptional Alterations in Myelodysplastic Syndrome

[Nature Communications] Researchers showed that the chromatin accessibility profiles of myelodysplastic syndrome stem cells more accurately reflect disease status than those of progenitor cells and reveal the process of stem cell alterations during disease progression.

ACBP/DBI Neutralization for the Prevention and Treatment of Malignant and Non-Malignant Liver Diseases

[Cell Death & Disease] The authors discuss current evidence suggesting that the acyl coenzyme A binding protein (ACBP)/diazepam binding inhibitor (DBI) system can be targeted for the prevention or treatment of a wide range of liver diseases.

NEK7 Couples SDHB to Orchestrate Respiratory Chain Electron Transport Homeostasis That Impedes Liver Fibrosis

[Nature Communications] Researchers found that NIMA-related kinase 7 (NEK7), targeted to mitochondria by its signal peptides, binds to succinate dehydrogenase complex iron sulfur subunit B (SDHB), stabilizing the spatial conformation of complex II and promoting forward electron transport.

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Noshin Noorjahan

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