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Noshin Noorjahan
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Multi-Omics and Single-Cell Insights Reveal a Lysophosphatidic Acid (LPA)-Mediated Resistant Mechanism to Third Generation EGFR-TKI in Non-Small Cell Lung Cancer
[Cancer Research] Investigators conducted plasma metabolomics analysis on 216 longitudinal samples from 186 NSCLC patients enrolled in the clinical trial of rezivertinib.
Cell Therapy News
CAR-Macrophage Cell Therapy: A New Era of Hope for Pancreatic Cancer
[Clinical Cancer Research] Investigators highlight recent advances in CAR-macrophage therapy for solid tumors, with an emphasis on pancreatic ductal adenocarcinoma.
Dermal Cell News
Impact of In Vitro Exposure to 5G-Modulated 3.5 GHz Fields on Oxidative Stress and DNA Repair in Skin Cells
[Scientific Reports] Researchers assessed whether exposure of human fibroblasts to 5G radiofrequency-electromagnetic fields at specific absorption rates of 0.08 and 4 W/kg for 24 h could alter basal reactive oxygen species (ROS) levels or potentiate the effects of known ROS inducers.
Neural Cell News
iPSC-Derived Cerebral Organoids Reveal Mitochondrial, Inflammatory, and Neuronal Vulnerabilities in Bipolar Disorder
[Translational Psychiatry] Researchers utilized iPSC-derived cerebral organoids from bipolar disorder patients and healthy controls to model disease-specific metabolic and inflammatory dysfunction in a more physiologically relevant system.
Neural Cell News
Probiotics Derived Sodium Benzoate Improves Social Behavior of Offspring Exposed in the Maternal Immune Activation through Regulation of Histone Lysine Benzoylation in Astrocytes
[Molecular Psychiatry] Single-cell RNA sequencing revealed that sodium benzoate restored the genes expression, like Cxcl16, in astrocytes of autistic mice, which is linked to glutamate metabolic activity between neurons and astrocytes.
Neural Cell News
Bcl11a Deficiency in Cerebellar Purkinje Cells Causes Ataxia and Autistic-Like Behavior by Altering Vav3
[Molecular Psychiatry] Investigators demonstrated that Bcl11a is predominantly expressed in Purkinje cells of both the developing and adult mouse cerebellum.
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Aberrant PJA2-CHRM3 Signaling Creates a Therapeutic Vulnerability in Gastric Tumor
[British Journal of Cancer] Scientists constructed mouse gastric organoids to recapitulate the morphological and functional characteristics of diffuse-type gastric cancer for FDA-approved drug screening.
Damon Runyon Cancer Research Foundation Awards $4.8 Million to Exceptional Early-Career Scientists
[Damon Runyon Cancer Research Foundation] The Damon Runyon Cancer Research Foundation has named 16 new Damon Runyon Fellows. This fellowship encourages young scientists to pursue careers in cancer research by providing them with independent funding to investigate cancer causes, mechanisms, therapies, and prevention.
Tumor Transcriptome-Wide Expression Classifiers Predict Treatment Sensitivity in Advanced Prostate Cancers
[Cell] To identify novel biomarker-treatment pairings, researchers examined associations between biological pathways and 14-year survival outcomes of patients randomized in practice-changing Phase III trials. They included transcriptome-wide expression signatures and immunohistochemistry markers on prostate tumors from 1,523 patients.
