Noshin Noorjahan

Endothelial Cell News

Endothelial IRE1 Signaling Maintains Blood-Brain Barrier Integrity and Limits Neuroinflammation after Traumatic Brain Injury

[Cell Death & Disease] The authors investigated the role of endothelial IRE1 signaling in traumatic brain injury using endothelial cell-specific IRE1 conditional knockout mice subjected to cortical ablation.

Endothelial Cell News

Endothelial TRIM47 Regulates Blood-Brain Barrier Integrity and Cognition via the KEAP1/NRF2 Signaling Pathway in Mice

[Communications Biology] Investigators devised a multilayered experimental plan to decipher the biological mechanisms underlying TRIM47’s role in cerebral small vessel disease pathophysiology.

Cancer Stem Cell News

Ebastine Targets HER2/HER3 Signaling and Cancer Stem Cell Traits to Overcome Trastuzumab Resistance in HER2‑Positive Breast Cancer

[International Journal of Molecular Medicine] Scientists evaluated the therapeutic potential of ebastine as a repurposing candidate to overcome trastuzumab resistance by targeting HER2 signaling and CSC‑associated phenotypes in HER2‑positive breast cancer cells.

Cancer Stem Cell News

OSBPL2-Mediated Lipid Metabolism Alteration Governs Lung Cancer Stem Cells Properties

[Stem Cell Research & Therapy] Investigators observed that oxysterol-binding protein-like 2 (OSBPL2) reduced cholesterol content by HPLC-MS. It inhibited the accumulation of lipid droplets in lung cancer.

Cancer Stem Cell News

SHH Pathway Inhibition and Astrocyte Co-Culture Induce Distinct Responses in Glioblastoma and Cancer Stem Cells

[Scientific Reports] The authors investigated how SHH pathway inhibition affects both bulk glioblastoma (GBM) cells and CD133+ GBM cells, with particular emphasis on the influence of astrocyte co-culture, which more closely mimics the brain tumor microenvironment.

Cancer Stem Cell News

Alpha-Fetoprotein Acts As a Key Regulator of Cancer Stemness in Hepatocellular Carcinoma via PI3K/Akt Pathway

[Cellular Signalling] Investigators employed CRISPR/Cas9-mediated gene editing to generate alpha-fetoprotein (AFP)-knockout models in Huh7 and PLC/PRF/5 cell lines, enabling a systematic investigation of AFP's oncogenic functions.

1...345...1,386 Page 4 of 1,386

Integrated Signatures Define Mutational Processes in Prostate Cancer

[Nature] Scientists dissected the mutational processes shaping the genomes of 959 donors from the Pan Prostate Cancer Group, identifying the etiologies and mutational processes that drive the genomic and clinical heterogeneity of prostate cancer.

Commensal Nakaseomyces Glabratus Migrates Into Prostate Tumors to Accelerate Cancer Progression

[Nature Cancer] Researchers found that oral administration of Nakaseomyces glabratus to castrated mice accelerated prostate cancer progression by promoting infiltration and activation of polymorphonuclear myeloid-derived suppressor cells.

Loss of NCOA6 Protein Causes Aggressive Prostate Cancer with EGFR Overexpression and Dependency

[Nature Communications] Investigators showed that genetic loss of NCOA6 accelerates tumor growth in human pancreatic cancer xenografts, induces prostate tumorigenesis in mice, and cooperates with Pten haploinsufficiency to drive aggressive metastatic pancreatic cancer.

All Articles by Author:

Noshin Noorjahan

Popular