Noshin Noorjahan

Endothelial Cell News

Endothelial IRE1 Signaling Maintains Blood-Brain Barrier Integrity and Limits Neuroinflammation after Traumatic Brain Injury

[Cell Death & Disease] The authors investigated the role of endothelial IRE1 signaling in traumatic brain injury using endothelial cell-specific IRE1 conditional knockout mice subjected to cortical ablation.

Endothelial Cell News

Endothelial TRIM47 Regulates Blood-Brain Barrier Integrity and Cognition via the KEAP1/NRF2 Signaling Pathway in Mice

[Communications Biology] Investigators devised a multilayered experimental plan to decipher the biological mechanisms underlying TRIM47’s role in cerebral small vessel disease pathophysiology.

Cancer Stem Cell News

Ebastine Targets HER2/HER3 Signaling and Cancer Stem Cell Traits to Overcome Trastuzumab Resistance in HER2‑Positive Breast Cancer

[International Journal of Molecular Medicine] Scientists evaluated the therapeutic potential of ebastine as a repurposing candidate to overcome trastuzumab resistance by targeting HER2 signaling and CSC‑associated phenotypes in HER2‑positive breast cancer cells.

Cancer Stem Cell News

OSBPL2-Mediated Lipid Metabolism Alteration Governs Lung Cancer Stem Cells Properties

[Stem Cell Research & Therapy] Investigators observed that oxysterol-binding protein-like 2 (OSBPL2) reduced cholesterol content by HPLC-MS. It inhibited the accumulation of lipid droplets in lung cancer.

Cancer Stem Cell News

SHH Pathway Inhibition and Astrocyte Co-Culture Induce Distinct Responses in Glioblastoma and Cancer Stem Cells

[Scientific Reports] The authors investigated how SHH pathway inhibition affects both bulk glioblastoma (GBM) cells and CD133+ GBM cells, with particular emphasis on the influence of astrocyte co-culture, which more closely mimics the brain tumor microenvironment.

Cancer Stem Cell News

Alpha-Fetoprotein Acts As a Key Regulator of Cancer Stemness in Hepatocellular Carcinoma via PI3K/Akt Pathway

[Cellular Signalling] Investigators employed CRISPR/Cas9-mediated gene editing to generate alpha-fetoprotein (AFP)-knockout models in Huh7 and PLC/PRF/5 cell lines, enabling a systematic investigation of AFP's oncogenic functions.

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Candida Albicans Synergizes with Fusobacterium Nucleatum in Colorectal Cancer Progression via the Flo9-RadD Interaction

[Cancer Cell] Researchers discovered that the commensal fungus Candida albicans synergizes with Fusobacterium nucleatum to promote colorectal cancer pathogenesis and contributes to poor patient outcomes.

A High-MAPK, Low-WNT Cell State Drives Metastatic Dissemination in Colorectal Cancer

[Nature Cancer] Using serial in vivo orthotopic passaging, investigators developed an immunocompetent mouse model of metastatic colorectal cancer.

Cannabidiol Triggers Fatty Acids β-oxidation Mediated by Stat2 to Facilitate Intestinal Stem Cells Regeneration Post Radiation

[Experimental & Molecular Medicine] Cannabidiol-a nonpsychotomimetic phytocannabinoid derived from the Cannabis sativa plant-was found to dramatically improve body weight loss of mice and stimulate Lgr5⁺ intestinal stem cells proliferation upon a lethal dose of irradiation.

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Noshin Noorjahan

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