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Noshin Noorjahan

Human Type-1 Innate Lymphoid Cells Control Leukemia Stem Cell Differentiation and Limit Acute Myeloid Leukemia Development

[Nature Communications] Researchers found that innate lymphoid cells (ILCs) in AML patients are impaired, with reduced total ILC1 numbers and diminished function.

The Oncogenic Role of Serum Marker GDF15 in Promoting Colorectal Tumorigenesis via EMT and Stemness

[Stem Cells International] GDF15 expression in colorectal cancer was analyzed using public databases and validated in patient tissues by Western blot.

Thyroid Hormone Inactivation Sustains Cancer Stem Cell Maintenance and Tumorigenesis in Basal Cell Carcinoma

[Journal of Investigative Dermatology] By integrating in vivo animal studies in a genetic mouse model of basal cell carcinoma (BCC) with analyses of human BCC specimens, the authors demonstrated that the deiodinase type 3 is expressed in the most tumorigenic CSC subpopulation.

Succinate Receptor 1 Restricts Hematopoiesis and Prevents Acute Myeloid Leukemia Progression

[Nature Communications] Scientists showed that low SUCNR1 represents a marker for reduced overall and progression-free survival in AML patients.

Intrinsic and Niche-Dependent Metabolic Regulation of Hematopoietic Stem Cells and Implications for Leukemogenesis

[Nature Cell Biology] The authors analyze recent advances in understanding the metabolic landscape of HSCs, emphasizing how their intrinsic bioenergetic programs facilitate quiescence, self-renewal, and differentiation.

HSCs/MPPs As Cells of Origin with Altered Differentiation Hierarchy Impairing Immunomicroenvironment in PML::RARA and CBFα/β Fusion AML

[Proceedings of The National Academy of Sciences of The United States of America] Using optimized single-cell technologies across three major AML subtypes, researchers found that AML-causing fusion transcription factors are expressed not only in leukemia blasts but also in seemingly normal, mature immune cells.

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Muscular Dystrophy Canada Announces Launch of National Neuromuscular Disease Real-World Experience Registry

[Muscular Dystrophy Canada] Muscular Dystrophy Canada announced the launch of the Neuromuscular Disease Real-World eXperience Registry designed to reshape neuromuscular research, policy, and care.

FDA Regenerative Medicine Advanced Therapy (RMAT) Designation for TN-401 for the Treatment of PKP2-Associated Arrhythmogenic Right Ventricular Cardiomyopathy

[Tenaya Therapeutics, Inc.] Tenaya Therapeutics, Inc. announced that the US FDA has granted Regenerative Medicine Advanced Therapy (RMAT) designation to TN-401, Tenaya’s gene therapy candidate for the treatment of PKP2-associated arrhythmogenic right ventricular cardiomyopathy.

The Molecular Landscape of Hypertrophic Cardiomyopathy across Disease Stages and Genotypes

[Science Translational Medicine] Scientists performed single-nucleus RNA sequencing of cardiac tissues from 47 patients with hypertrophic cardiomyopathy and compared them with nonfailing donor and dilated cardiomyopathy hearts to investigate stage- and genotype-specific disease mechanisms.