Noshin Noorjahan

Cancer Stem Cell News

Human Type-1 Innate Lymphoid Cells Control Leukemia Stem Cell Differentiation and Limit Acute Myeloid Leukemia Development

[Nature Communications] Researchers found that innate lymphoid cells (ILCs) in AML patients are impaired, with reduced total ILC1 numbers and diminished function.

Cancer Stem Cell News

The Oncogenic Role of Serum Marker GDF15 in Promoting Colorectal Tumorigenesis via EMT and Stemness

[Stem Cells International] GDF15 expression in colorectal cancer was analyzed using public databases and validated in patient tissues by Western blot.

Cancer Stem Cell News

Thyroid Hormone Inactivation Sustains Cancer Stem Cell Maintenance and Tumorigenesis in Basal Cell Carcinoma

[Journal of Investigative Dermatology] By integrating in vivo animal studies in a genetic mouse model of basal cell carcinoma (BCC) with analyses of human BCC specimens, the authors demonstrated that the deiodinase type 3 is expressed in the most tumorigenic CSC subpopulation.

Hematopoiesis News

Succinate Receptor 1 Restricts Hematopoiesis and Prevents Acute Myeloid Leukemia Progression

[Nature Communications] Scientists showed that low SUCNR1 represents a marker for reduced overall and progression-free survival in AML patients.

Hematopoiesis News

Intrinsic and Niche-Dependent Metabolic Regulation of Hematopoietic Stem Cells and Implications for Leukemogenesis

[Nature Cell Biology] The authors analyze recent advances in understanding the metabolic landscape of HSCs, emphasizing how their intrinsic bioenergetic programs facilitate quiescence, self-renewal, and differentiation.

Hematopoiesis News

HSCs/MPPs As Cells of Origin with Altered Differentiation Hierarchy Impairing Immunomicroenvironment in PML::RARA and CBFα/β Fusion AML

[Proceedings of The National Academy of Sciences of The United States of America] Using optimized single-cell technologies across three major AML subtypes, researchers found that AML-causing fusion transcription factors are expressed not only in leukemia blasts but also in seemingly normal, mature immune cells.

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RadioMedix Announces Receiving FDA Approval of Its Generic Ga-68 PSMA-11 Radiodiagnostic for Prostate Cancer

[RadioMedix, Inc.] RadioMedix, Inc. announced that the US FDA has approved Ga 68 PSMA-11, a prostate-specific membrane antigen (PSMA)-targeted diagnostic radiopharmaceutical for positron emission tomography imaging in patients with prostate cancer.

CPRIT Invests Over $11 Million to Fuel UH Breakthroughs in Cancer Research

[University of Houston] With $250,000 in Cancer Prevention and Research Institute of Texas (CPRIT) funding, Dr. Qin Feng, associate professor of biology and biochemistry, is working to stop the progression of prostate cancer. Her research goal is to provide a new treatment option for prostate cancer patients, especially those resistant to current therapies.

MCCC2 Stabilizes LTBP1 via Suppressing SMURF1-Dependent Ubiquitination to Drive Bone Metastasis in Prostate Cancer

[Oncogene] Liquid chromatography-mass spectrometry identified LTBP1 as a direct interacting partner of methylcrotonyl-CoA carboxylase subunit 2 (MCCC2). Functional studies demonstrated that MCCC2 promotes prostate cancer cell migration, invasion in vitro, and bone metastasis in vivo.

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Noshin Noorjahan

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