[Nature Communications] Researchers found that innate lymphoid cells (ILCs) in AML patients are impaired, with reduced total ILC1 numbers and diminished function.
[Journal of Investigative Dermatology] By integrating in vivo animal studies in a genetic mouse model of basal cell carcinoma (BCC) with analyses of human BCC specimens, the authors demonstrated that the deiodinase type 3 is expressed in the most tumorigenic CSC subpopulation.
[Nature Cell Biology] The authors analyze recent advances in understanding the metabolic landscape of HSCs, emphasizing how their intrinsic bioenergetic programs facilitate quiescence, self-renewal, and differentiation.
[Proceedings of The National Academy of Sciences of The United States of America] Using optimized single-cell technologies across three major AML subtypes, researchers found that AML-causing fusion transcription factors are expressed not only in leukemia blasts but also in seemingly normal, mature immune cells.
[Muscular Dystrophy Canada] Muscular Dystrophy Canada announced the launch of the Neuromuscular Disease Real-World eXperience Registry designed to reshape neuromuscular research, policy, and care.
[Tenaya Therapeutics, Inc.] Tenaya Therapeutics, Inc. announced that the US FDA has granted Regenerative Medicine Advanced Therapy (RMAT) designation to TN-401, Tenaya’s gene therapy candidate for the treatment of PKP2-associated arrhythmogenic right ventricular cardiomyopathy.
[Science Translational Medicine] Scientists performed single-nucleus RNA sequencing of cardiac tissues from 47 patients with hypertrophic cardiomyopathy and compared them with nonfailing donor and dilated cardiomyopathy hearts to investigate stage- and genotype-specific disease mechanisms.