Noshin Noorjahan

Hematopoiesis News

Ex Vivo Long-Term Expansion of Human Hematopoietic Stem and Progenitor Cells As a Tool for Modeling Vector Integration Sites and Clonality

[Journal of Translational Medicine] The small molecules A83-01, pomalidomide, and UM171 were used for the ex vivo expansion, lentiviral transduction, and long-term cultivation of umbilical cord blood-derived hematopoietic stem and progenitor cells.

Hematopoiesis News

RTX-Family Toxin EhxA Drives Morphological Remodeling and Thrombogenesis in RBCs during Enterohemorrhagic Escherichia Coli Infection

[Science Advances] Investigators identified the RTX-family hemolysin EhxA as the driver of RBC-mediated thrombogenesis.

Hematopoiesis News

DHX9 Sustains Hematopoietic Stem Cell Function in Cooperation with H3 Acetylation

[Stem Cell Reports] The authors identified DHX9 as a critical regulator of HSC maintenance. Dhx9 deletion caused bone marrow failure and impaired hematopoietic reconstitution in murine primary and secondary transplantation recipients due to loss of HSCs and defective self-renewal capacity.

Dermal Cell News

Hydroxypinacolone 9-cis Retinoate Mitigates UV-Induced Photoaging by Modulating ECM, Fibroblasts, Inflammation, and Melanogenesis

[Journal of Investigative Dermatology] Single-cell RNA sequencing and spatial transcriptomics revealed restoration of fibroblast, basal cell, and melanocyte proportions, suppression of myofibroblast differentiation, and upregulation of ECM-related genes.

Dermal Cell News

Dermal Microvascular Responses of Human IPSC-Derived Skin Organoids to Inflammation and Injury

[American Journal of Pathology] Reseachers profiled temporal dynamics of human stem cell-derived skin organoid vasculogenesis and interrogated organoid responses to inflammatory and traumatic stimuli.

Dermal Cell News

Plakoglobin Phosphorylation at Serine 665 Is Capable of Stabilizing Cadherin-Mediated Adhesion in Keratinocytes

[JCI Insight] Scientists investigated the relevance of plakoglobin phosphorylation at S665 for stabilization of keratinocyte cohesion and further characterized the underlying mechanisms.

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Muscular Dystrophy Canada Announces Launch of National Neuromuscular Disease Real-World Experience Registry

[Muscular Dystrophy Canada] Muscular Dystrophy Canada announced the launch of the Neuromuscular Disease Real-World eXperience Registry designed to reshape neuromuscular research, policy, and care.

FDA Regenerative Medicine Advanced Therapy (RMAT) Designation for TN-401 for the Treatment of PKP2-Associated Arrhythmogenic Right Ventricular Cardiomyopathy

[Tenaya Therapeutics, Inc.] Tenaya Therapeutics, Inc. announced that the US FDA has granted Regenerative Medicine Advanced Therapy (RMAT) designation to TN-401, Tenaya’s gene therapy candidate for the treatment of PKP2-associated arrhythmogenic right ventricular cardiomyopathy.

The Molecular Landscape of Hypertrophic Cardiomyopathy across Disease Stages and Genotypes

[Science Translational Medicine] Scientists performed single-nucleus RNA sequencing of cardiac tissues from 47 patients with hypertrophic cardiomyopathy and compared them with nonfailing donor and dilated cardiomyopathy hearts to investigate stage- and genotype-specific disease mechanisms.

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Noshin Noorjahan

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