Noshin Noorjahan

Dermal Cell News

miRNA-Driven Cancer Cell Plasticity, Tolerance, and Therapy Resistance: Lessons from Melanoma

[Molecular Cancer] Investigators combine current knowledge on phenotypic plasticity, drug-tolerant states, and microenvironmental remodeling, with miRNA regulation.

Dermal Cell News

RIPK4 Function Interferes with Melanoma Cell Adhesion and Metastasis

[Molecular Oncology] Using an integrated approach involving clinical samples, in vivo xenograft models, transcriptomic analysis, and 3D functional assays, scientists showed that receptor-interacting protein kinase 4 (RIPK4) deletion significantly reduces pulmonary metastasis formation.

Dermal Cell News

Hair Follicle Organoids Using Human iPSC-Derived Ectodermal Precursor Cells for Hair Regenerative Medicine

[ACS Biomaterials Science & Engineering] Researchers aimed to differentiate hiPSCs into hair follicle epithelial and mesenchymal stem cells, and to subsequently purify and use them to generate hair follicle organoids.

Cancer Stem Cell News

CircKIAA1617 Promotes Stemness via USP14/PGRMC1-Mediated Autophagy and Lipid Metabolism Reprogramming in ER-Positive Breast Cancer

[Molecular Cancer] CircKIAA1617 was identified through high-throughput RNA sequencing in ER-positive breast cancer (BC) . Gain- and loss-of-function assays were performed to evaluate the functions of circKIAA1617 in ER-positive BC cells.

Cancer Stem Cell News

HNRNPF Increases MAF and CCNB2 Levels To Promote Cancer Cell Stemness and Progression of Pancreatic Ductal Adenocarcinoma

[Stem Cell Reviews and Reports] The authors investigated the impact of heterogeneous nuclear ribonucleoprotein F (HNRNPF) on tumor stemness by regulating musculoaponeurotic fibrosarcoma (MAF) stability and cyclin B2 (CCNB2) transcription in pancreatic ductal adenocarcinoma.

Cancer Stem Cell News

Targeting Wnt3a and Loxl2 Synergistically Induces Ferroptosis in Liver Cancer Stem Cells and Suppresses Tumorigenesis

[Cancer Science] The authors investigated how Wnt3a and/or Loxl2 knockdown affects liver CSCs and orthotopic tumor growth in mice, and explores the role of ferroptosis-related genes.

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Muscular Dystrophy Canada Announces Launch of National Neuromuscular Disease Real-World Experience Registry

[Muscular Dystrophy Canada] Muscular Dystrophy Canada announced the launch of the Neuromuscular Disease Real-World eXperience Registry designed to reshape neuromuscular research, policy, and care.

FDA Regenerative Medicine Advanced Therapy (RMAT) Designation for TN-401 for the Treatment of PKP2-Associated Arrhythmogenic Right Ventricular Cardiomyopathy

[Tenaya Therapeutics, Inc.] Tenaya Therapeutics, Inc. announced that the US FDA has granted Regenerative Medicine Advanced Therapy (RMAT) designation to TN-401, Tenaya’s gene therapy candidate for the treatment of PKP2-associated arrhythmogenic right ventricular cardiomyopathy.

The Molecular Landscape of Hypertrophic Cardiomyopathy across Disease Stages and Genotypes

[Science Translational Medicine] Scientists performed single-nucleus RNA sequencing of cardiac tissues from 47 patients with hypertrophic cardiomyopathy and compared them with nonfailing donor and dilated cardiomyopathy hearts to investigate stage- and genotype-specific disease mechanisms.

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Noshin Noorjahan

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