Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
Cancer Stem Cell News
Cancer Stem Cell News is an online resource that curates the top research publications and reviews about cancer progenitor cells and cancer stem cells.
Subscribe|Follow Us On
Targeting Kinesin Family Member 20A Sensitizes Stem-Like Triple-Negative Breast Cancer Cells to Standard Chemotherapy
[Journal of Clinical Investigation] Investigators dissected the transcriptome of breast CSCs (BCSCs) and identified kinesin family member 20A as a key regulator of BCSC survival and triple negative breast cancer tumorigenesis.
Targeting of the m6a Eraser ALKBH5 Suppresses Stemness and Chemoresistance of Colorectal Cancer
[Nature Communications] Researchers found that AlkB homolog 5 (ALKBH5) expression positively correlates with CSC markers in colorectal cancer patients. ALKBH5 induces self-renewal and stemness markers in colorectal CSCs and patient-derived organoids.
Targeting Chaperone-Mediated Autophagy Inhibits Properties of Glioblastoma Stem Cells and Restores Anti-Tumor Immunity
[Nature Communications] Investigators showed that chaperone-mediated autophagy (CMA) is upregulated in patient-derived glioblastoma stem cells, indicated by a significant increase in the lysosomal abundance of the CMA receptor, lysosome-associated membrane protein 2 A.
HIF-1-Mediated ISG20 Expression Promotes Breast Cancer Stemness and Immune Evasion
[Journal of Experimental Medicine] The authors demonstrated that transcription of the ISG20 gene, which encodes an RNA exonuclease, is activated by HIF-1 in triple negative breast cancer cells.
Matrix Stiffness Maintains Bladder Cancer Stemness via Integrin-Nuclear Skeleton Axis
[Cell Death & Disease] Scientists showed that as bladder cancer progresses, matrix stiffness increases, and tumor stemness increases.
Tumor-Educated-Platelets Interact with Breast Cancer-Stem-Cells via P-Selectin-PSGL1 and Ensure Stemness and Metastasis through WNT-β-Catenin-VEGF-VEGFR2 Intra-Cellular Signaling: Therapeutic Modulation by Aspirin
[Breast Cancer Research] Impact of tumor educated platelets on breast CSCs was evaluated from primary breast tumor and blood samples of luminal A/triple negative breast cancer patients along with EC/4T1 murine breast tumor models and MCF-7/MDA-MB-231 cell lines.
NRAV Promotes HCC Stemness via the m6a-Regulated Let-7c-5p/LIN28B Axis
[Cancer Gene Therapy] Investigators identified negative regulator of antiviral response (NRAV) as an m6A-modified lncRNA that promotes HCC stemness through a defined molecular axis.
Inhibition of the Mevalonate Pathway Targets Neuroblastoma Stem Cells
[Pharmacology] Researchers observed the use of mevalonate pathway inhibitors against the CSC population of high-risk neuroblastoma cell lines SH-SY5Y, SK-N-AS, and SK-N-BE(2)-C using spheroid-based assays.
Dysregulation of the Cyclin D/E2F Activity As a Core Mechanism Driving Cancer Stem Cell Plasticity and Cell Cycle Dynamics
[Cell Cycle] The authors outline a conceptual model that integrates aberrant G1/S control with CSC state transitions.
Engineering CAR T NK and NKT Cell Therapies to Target Cancer Stem Cells and Overcome Stem like Resistance
[Discover Oncology] Investigators provide a comprehensive overview of CSC biology, the foundational principles of CAR engineering, and the current clinical landscape of these cellular immunotherapies.
UT Health San Antonio Awarded $3 Million CPRIT Grant to Bolster Cancer Research and Prevention Efforts in South Texas
[UT Health San Antonio] UT Health San Antonio received nearly $3 million in new academic and prevention awards as part of the latest, almost $154 million funding round announced by the Cancer Prevention Research Institute of Texas (CPRIT).
Microenvironmental Cell Interactions Are Essential for Sustaining Functionality of Myelofibrosis Malignant Stem Cells
[Blood] To model in vivo cancer stem cell/tumor microenvironment interactions and elucidate their functional consequences, scientists focused on myelofibrosis, a stem cell driven myeloproliferative neoplasm.
Cancer Stem Cell News consolidates the most recent publications covering research areas such as the identification and isolation of cancer stem cells, their proliferation and differentiation characteristics, gene expression and regulatory pathways, and the development of anti-cancer therapies. We also include cancer stem cell jobs and events hosted by leading research organizations, societies, and institutes.
