Cancer Stem Cell News

Cancer Stem Cell News is an online resource that curates the top research publications and reviews about cancer progenitor cells and cancer stem cells.

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Targeting Cancer Stem Cells Enhances Multikinase Inhibitor Therapy in Metabolic Dysfunction-Associated Steatotic Liver Disease-Related Hepatocellular Carcinoma

August 14, 2026

[Gut] Researchers characterised CSCs in metabolic dysfunction-associated steatotic liver disease-related hepatocellular carcinoma (MASLD-HCC) and investigated their contribution to MASLD-HCC tumourigenesis and therapy response.

Translational Insights and Clinical Challenges of Targeting Cancer Stem Cells

August 14, 2026

[Signal Transduction and Targeted Therapy] The authors discusss current concepts of CSC origin and plasticity, the criteria used to define CSCs across different tumor types, and the marker systems as well as high-resolution technologies that are used to track CSC states.

LINC02709 Facilitates Hepatocellular Carcinoma Metastasis by Increasing Stem Cell-Like Properties and Suppressing Kupffer Cell Phagocytosis

August 14, 2026

[Cell Death DIscovery] Scientists found that the long noncoding RNA LINC02709 was upregulated in hepatocellular carcinoma and correlated with stemness properties, intrahepatic metastasis, and poor prognosis.

Integrative 3D Genome and Epigenomic Analysis Identifies TP53RK and SYBU As Critical Regulators of Stemness and Anti-Tumor Immunity in HCC

August 14, 2026

[Cell Reports] Researchers delineated the 3D chromatin landscapes of well- and poorly differentiated hepatocellular carcinoma cells and uncovered stemness-associated rewiring of A/B compartmentalization, topologically associating domain boundaries, and enhancer-promoter loops.

Metabolic Reprogramming in Glioblastoma Stem Cells Promotes Radiation Resistance through a H3K18la/USP30/MBOAT2 Axis

August 14, 2026

[Advanced Science] Investigators showed that mesenchymal (MES) glioma stem cells exhibit enhanced glycolytic activity and lactate production, driven in part by MES-associated transcriptional regulators that promote LDHA expression.

MHY5535, a Novel PPARα Antagonist, Sensitizes Ovarian Cancer Stem Cells to Chemotherapy by Disrupting Fatty Acid Oxidation-Dependent Mitochondrial Metabolism

August 14, 2026

[Biomedicine & Pharmacotherapy] The authors identified MHY5535 as a potent PPARα antagonist and characterized its efficacy in disrupting the mitochondrial metabolic support of ovarian CSCs.

P38β-mediated BiP Phosphorylation Drives Stemness and Chemoresistance by Suppressing UPR Activation in Hepatocellular Carcinoma

August 5, 2026

[Nature Communications] Scientists identified the stress kinase p38β (MAPK11) supports tumor-initiating cell maintenance and drug resistance in hepatocellular carcinoma (HCC). Integrated analysis of chemotherapy-enriched HCC spheroids, and DepMap data prioritized p38β as a kinase linked to stemness and chemoresistance.

Mercer School of Medicine Awarded $100,000 Cancer Research Grant

August 5, 2026

[The Den] Mercer University School of Medicine has been awarded the fifth annual Collaborative Cancer Research Seed Grant of $100,000 to advance research aimed at improving treatment for one of the most aggressive forms of endometrial cancer. This grant will support a research project led by Dr. Ilana Chefetz Menaker.

$12.7 Million for Cancer, Heart, and Health Research

August 5, 2026

[Queen's Gazette] 13 research teams at Queen’s University have received a combined $12.7 million from the Canadian Institutes of Health Research (CIHR). Awarded through CIHR's Project Grant: Spring 2026 competition, each project will work towards advancing the wellbeing of Canadians through translational research.

Nanotechnology-Enabled Precision Targeting of Lung Cancer Stem Cells: Recent Developments and Therapeutic Implications

August 5, 2026

[Stem Cell Reviews and Reports] The authors summarize current nanotechnology-enabled strategies targeting lung cancer stem cells, with particular emphasis on tumor microenvironment remodeling, metabolic regulation, and tumor immunity.

Current Therapeutic Interventions to Target Cancer Stem Cells for Metastasis

August 5, 2026

[International Journal of Clinical Oncology] Since CSCs are the major cause of metastatic spread, emerging therapeutic modalities specifically targeting CSCs present a lucrative approach to curtail metastatic disease.

WDR72 Promotes Neuroblastoma Stemness and Progression by Sequestering TRIM31-Mediated Degradation of CBX8

August 5, 2026

[Advanced Science] Researchers identifeid WD repeat domain 72 (WDR72) as a cancer stem cell marker that significantly correlates with high-risk of neuroblastoma and poor prognosis in neuroblastoma patients.

Cancer Stem Cell News consolidates the most recent publications covering research areas such as the identification and isolation of cancer stem cells, their proliferation and differentiation characteristics, gene expression and regulatory pathways, and the development of anti-cancer therapies. We also include cancer stem cell jobs and events hosted by leading research organizations, societies, and institutes.