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Cancer Stem Cell News is an online resource that curates the top research publications and reviews about cancer progenitor cells and cancer stem cells.
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Dr. Antoni Ribas Receives ESMO Lifetime Achievement Award for Contributions to Cancer Immunotherapy
[UCLA Health] Dr. Antoni Ribas, professor of medicine at the David Geffen School of Medicine at UCLA has received the 2026 ESMO Lifetime Achievement Award for his pioneering contributions to cancer immunotherapy and translational research.
AML1-ETO Hijacks a Distal Enhancer of NAT10 to Reprogram Glutathione Metabolism and Sustain Leukemia Stem Cell Stemness
[Proceedings of The National Academy of Sciences of The United States of America] Genetic ablation or pharmacological inhibition of NAT10 restricted the survival and self-renewal of LSCs in primary t(8;21) acute myeloid leukemia (AML) CD34+ cells, as well as in a retroviral AML1-ETO9a-driven t(8;21) AML mouse model.
Stemness As a Systems-Level State: From Ancestral Plasticity to Systemic Control in Regeneration, Aging, and Cancer
[Annual Review of Genetics] The authors examine early-diverging metazoans to reevaluate the evolutionary logic of stemness. Rather than viewing stem cells as exceptional, we argue that cellular plasticity represents a deeply conserved attribute of early life.
POC1A Promotes the Proliferation, Metastasis, and Stemness of Bladder Cancer by Stabilizing BMI1 via USP7
[Oncogene] Researchers investigated a critical molecular mechanism driving advanced bladder cancer (BLCA) progression. In vitro and in vivo analyses indicate that POC1A knockdown inhibits BLCA cell proliferation, metastasis, and stemness.
Abexinostat Attenuates Temozolomide-Resistant Glioma Stem Cells
[Neuro-Oncology] Researchers demonstrated the anti-proliferative effect of Abexinostat (Abx) on both differentiated cells and glioma stem cells (GSC). Abx reduced both DNA repair machinery and GSC markers by decreasing chromatin accessibility.
NRF2-WNT5A Promotes Stem Cell Persistence and Radioresistance in Esophageal Squamous Cancer
[Cell Death & Disease] Integrating 3D cancer spheroid models with RNA-seq analysis, the authors investigated NRF2 hyperactivation in CSCs and its role as a core mediator of CSC-associated radioresistance and stemness via the canonical WNT/β-catenin pathway.
Stanniocalcin 1 Contributes to Glioma Stem Cells Phenotypic Plasticity through NOTCH1/STAT3/GFPT2 Axis
[Oncogenesis] Investigators revealed that stanniocalcin 1 (STC1) is a key regulator of GSC phenotypic plasticity and aggressiveness through the NOTCH1/STAT3/GFPT2/O-GlcNAcylation pathway.
NKCC1 As a Regulator of Stemness and Redox Balance in Colorectal Cancer
[Oncogenesis] Scientists identified NKCC1 as a marker of normal intestinal stem cells, supported by its crypt-base localization, single-cell transcriptomics, and patient-derived organoids, while analyses of public colorectal cancer single-cell datasets further link NKCC1 expression to cancer stem cell populations.
Glycolytic Enolase 1-Induced H4K12 Lactylation Activates Quiescent Breast Cancer Stem-Like Cells in Triple-Negative Breast Cancer
[Signal Transduction and Targeted Therapy] Researchers developed a dual-reporter system combining NANOG-EGFP and H2B-mCherry pulse-chase labeling to separately identify quiescent or extremely slow-cycling breast cancer stem-like cells and active BCSCs in vitro and in vivo.
ESMO Announces 2026 Society Award Recipients Honouring Excellence in Cancer Research, Care, and Leadership
[ESMO] ESMO has announced the recipients of the 2026 ESMO Society Awards, recognising four outstanding oncology professionals whose contributions have advanced cancer research, enhanced clinical care, and strengthened the global oncology community.
Oral Nano-Delivery of a Gut Microbial Metabolite Enhances T Cell Stemness for Cancer Immunotherapy
[Nature Nanotechnology] Through an in vitro screening of gut microbial metabolites, scientists identified 3,4-dihydroxybenzoic acid that improved adoptive T cell therapy and enhanced CD8+ T cell stemness by suppressing glycolysis and regulating the Akt-mTORC1-Myc pathway.
American Cancer Society Announces $5.45 Million Gift from Lisa Dean Moseley Foundation to Launch New Postdoctoral Fellows Fund
[American Cancer Society] The American Cancer Society announced a new $5.45 million commitment from the Lisa Dean Moseley Foundation. Among the partnership's most significant achievements is the American Cancer Society-Lisa Dean Moseley Foundation Cancer Stem Cell Consortium.
Cancer Stem Cell News consolidates the most recent publications covering research areas such as the identification and isolation of cancer stem cells, their proliferation and differentiation characteristics, gene expression and regulatory pathways, and the development of anti-cancer therapies. We also include cancer stem cell jobs and events hosted by leading research organizations, societies, and institutes.
