Cancer Stem Cell News

Cancer Stem Cell News is an online resource that curates the top research publications and reviews about cancer progenitor cells and cancer stem cells.

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Troester Receives Leadership Grant from Susan G. Komen

June 24, 2026

[University of North Carolina at Chapel Hil] Dr. Melissa Troester received a Leadership Grant from Susan G. Komen as part of a continuing commitment to accelerating breast cancer research. The new grant will support Troester’s advances in spatial biology – an understanding of how distances between cancer cells and immune cells alter breast cancer outcomes.

From Ferroptotic Stress to Stemness: TNT-Mediated EMT Plasticity in Cancer Progression

June 24, 2026

[Stem Cell Reviews and Reports] Researchers outline an integrative framework connecting ferroptosis, epithelial-mesenchymal transition plasticity, tunneling nanotube-mediated communication and CSC dynamics, offering insights into novel strategies to overcome therapeutic resistance, prevent metastatic dissemination and limit tumor relapse.

The Role of Stem Cells in Pituitary Tumor Formation

June 24, 2026

[Endocrine-Related Cancer] The authors summarize current evidence implicating pituitary stem cells and tumor stem-like populations in pituitary tumor biology, including potential roles in tumor initiation, maintenance and progression.

mir-34a-5p-Mediated Inhibition on the KRT5/DSP Axis Blunts Cancer Stem Cell Properties and Cisplatin Resistance in Non-Small Cell Lung Cance

June 24, 2026

[Discover Oncology] This research seeks to clarify how miR-34a-5p influences CSC characteristics and resistance to cisplatin (DDP) in non-small cell lung cancer (NSCLC). By targeting the KRT5/DSP axis, miR-34a-5p was shown to suppress CSC properties and enhance DDP sensitivity in NSCLC cells.

Late-Stage Dedifferentiation and Epigenetic Memory of Cancer Stem Cells in Hepatocellular Carcinoma

June 24, 2026

[Journal of Translational Medicine] Scientists proposed a framework in which hepatocytes dedifferentiate into bipotent progenitors as a pre-malignant state, undergo malignant transformation, and a subset acquires stemness through DNA methyltransferase-mediated reprogramming stabilized by epigenetic memory.

Acquisition of Vimentin by Trogocytosis Inhibits the NK Cell-Mediated Immune Response against Circulating Tumor Cells (CTCs)

June 24, 2026

[Cellular & Molecular Immunology] Scientists showed that pharmacological inhibition of vimentin trogocytosis increases the efficacy of NK cells in clearing circulating tumor cells in vivo and that of NK cell-based adoptive immunotherapies.

Interaction Between FKBP10 and HSP10 Activates the TGF-β/Smad Pathway to Promote the Maintenance of Osteosarcoma Stemness

June 24, 2026

[Cellular Signalling] Researchers investigated the role and molecular mechanism of FK506-binding protein 10 (FKBP10) in regulating osteosarcoma stemness and malignant progression.

Human Cerebral Organoids with Microglia and Vasculature Model Glioma Stem Cell Interactions and Radiotherapy Response

June 24, 2026

[Cell Reports Methods] By co-culturing complex cerebral organoids with glioma stem cells, the authors demonstrated that their model recapitulated the tumor niche of glioblastoma, showing vascular co-option, reprogramming of microglia into tumor-associated macrophages, and recurrence after radiotherapy.

Polarity Protein MALS3 Suppresses Breast Cancer Stem Cell-Like Properties by Promoting TAZ Inactivation and Ubiquitination-Dependent Degradation

June 24, 2026

[Cell Death & Disease] Scientists identified that the loss of the polarity protein MALS3 disrupts the homeostasis of mammary epithelial cells while increasing breast cancer stem cell-like properties.

ZEB1 Integrates Stemness, Differentiation Blockade, and Immune Suppression to Orchestrate Osteosarcoma Aggressiveness

June 24, 2026

[Journal of Experimental & Clinical Cancer Research] Using in vitro functional assays, researchers assessed the effect of ZEB1 down-modulation on stemness, anchorage-independent growth, chemotherapy sensitivity, and osteoblastic differentiation, while gene expression profiling provided hints on ZEB1 regulation of tumor cell transcriptional program.

Cancer Stem Cells Orchestrate Immune Evasion through Extracellular Vesicle-Mediated Non-Canonical Signaling Pathways

June 10, 2026

[Cancer Cell] Using multiplexed single-cell proteomics to analyze 50 tumor microenvironment-associated proteins across treatment-naive triple-negative breast cancer specimens, we discovered that CSCs drive differentiation and expansion of regulatory T cells via extracellular vesicle-mediated paracrine signaling.

Leukemic Stem Cell Subtypes Determine Venetoclax Resistance and Therapeutic Vulnerabilities in AML

June 10, 2026

[Cell Stem Cell] Researchers revealed four distinct leukemic stem cell types with unique vulnerabilities and propose biomarker-guided treatment strategies that complement genetic profiling to overcome venetoclax resistance.

Cancer Stem Cell News consolidates the most recent publications covering research areas such as the identification and isolation of cancer stem cells, their proliferation and differentiation characteristics, gene expression and regulatory pathways, and the development of anti-cancer therapies. We also include cancer stem cell jobs and events hosted by leading research organizations, societies, and institutes.