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Cancer Stem Cell News is an online resource that curates the top research publications and reviews about cancer progenitor cells and cancer stem cells.
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MMRN1-EGFR Drives Sialylglycan-Siglec Immune Evasion in AML Leukemia Stem Cells
[Cell Stem Cell] Scientists identified multimerin 1 (MMRN1) as being highly and specifically expressed in leukemia stem cells (LSC). They established MMRN1 as a dual-functional target for LSC maintenance and immune evasion and propose that disrupting MMRN1 or EGFR remodels the immunosuppressive tumor microenvironment.
STAT3 Signaling Mediates EGFR-TKI Resistance in Non-Small Cell Lung Cancer by Regulating Stemness Markers and Telomerase, Reversed by Icaritin
[British Journal of Cancer] The authors found that inhibition of the MAPK pathway by EGFR-tyrosine kinase inhibitors triggers the rapid activation of STAT3 in non-small cell lung cancer. RNA-seq analysis and cellular experiments confirmed that STAT3 regulates the expression of stemness markers, which contribute to drug resistance.
Surface CD81 Supports Leukemia Stem Cell Function and Reveals a Therapeutic Vulnerability in Acute Myeloid Leukemia
[Signal Transduction and Targeted Therapy] Investigators identified the tetraspanin CD81 as a regulator of leukemia stem cells function, progression and treatment resistance in acute myeloid leukemia.
Cholesterol Synthases Suppress Metastasis and Stemness through PDIA4/ACLY or SYVN1/SCD1 Axis in Advanced Colorectal Cancer
[Communications Biology] Scientists demonstrated that suppress of cholesterol synthases FDFT1 or SQLE enhances colorectal cancer metastasis and stemness through impairing ER stress and degrading PDIA4 or SYVN1 individually.
Blocking Ubiquitination of hnRNPA1 Maintains the Self-Renewal of Breast Cancer Stem Cells via Mutually Exclusive Splicing of PKM Pre-mRNA
[Oncogene] Investigators reported that PKM2 expression is upregulated in breast CSCs (BCSCs). LINC00887 maintains the self-renewal of BCSCs by promoting PKM2 splicing and reprogramming glucose metabolism.
Progesterone Receptors Drive Advanced Breast Cancer Phenotypes Including Circulating tumor- and Stem-Like Cell Expansion in the Context of ESR1 Mutation
[NPJ Breast Cancer] Scientists investigated progesterone receptor-dependent transcriptional programs such as the unfolded protein response that can be leveraged to target CSCs in Y537S estrogen receptor gene (ESR1)-mutant breast cancer.
Nuclear Hexokinase 2 Couples Hyperglycemia to MYC-Driven Glycolytic and Stemness Programs in Bladder Cancer
[Cell Death & Disease] Researchers identified a noncanonical, nuclear role of hexokinase 2 that couples systemic hyperglycemia to MYC-driven glycolysis and stemness in bladder cancer.
Regulating the Dormancy of Cancer Stem Cells: A Novel Approach to Preventing Cancer Relapse
[Cell Death & Disease] Several new specific markers of dormant CSCs, such as p27, CD13, QSOX1, Survivin, GPD1 and BEX2, have been identified, which offer hope for targeted therapy. The authors examine recent significant findings regarding tumor stem cell dormancy in both experimental and human disease models.
The Metabolic Profiles of Cancer Stem Cells
[Stem Cell Research & Therapy] The authors highlight unresolved issues and further outline key contextual factors, including tumor-intrinsic, microenvironmental, systemic, and metastatic cues, that shape CSC metabolism and help explain the divergent observations reported across studies.
Metabolic Oxidoreductases: Central Regulators of the Epigenetic Landscapes in Stemness
[Experimental & Molecular Medicine] Scientists outline emerging mechanisms by which oxidoreductases couple metabolic flux to epigenetic landscapes that maintain or dissolve stemness.
Activity of PROTAC MDM2 Degrader in Primary Leukemia Cells and PDX Models
[Leukemia] MD-265 is a PROTAC that recruits cereblon, degrades MDM2, restores p53 and induces apoptosis. Researchers tested MD-265 in ex vivo cultures of 105 primary leukemic stem cells.
Allosteric Inhibition of RAN Decreases Mir-126 Biogenesis in Endothelial Cells and Controls Acute Myeloid Leukemia Growth
[Communications Biology] In an AML murine model, MAR-3.6.2, a novel allosteric inhibitor that binds in a cryptic pocket in the C-terminal domain of RAN, reduced leukemia burden, prolonged survival, and decreased leukemia stem cell frequency in secondary transplants.
Cancer Stem Cell News consolidates the most recent publications covering research areas such as the identification and isolation of cancer stem cells, their proliferation and differentiation characteristics, gene expression and regulatory pathways, and the development of anti-cancer therapies. We also include cancer stem cell jobs and events hosted by leading research organizations, societies, and institutes.
