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Cancer Stem Cell News
Cancer Stem Cell News is an online resource that curates the top research publications and reviews about cancer progenitor cells and cancer stem cells.
Providence and Ontario Institute for Cancer Research (OICR) Partnering to Discover and Develop mRNA Therapeutics
[Providence Therapeutics, Inc.] Providence Therapeutic Holdings, Inc. and the Ontario Institute for Cancer Research announced the signing of a collaboration agreement for mRNA drug discovery and development.
Dark Force Rising: Reawakening and Targeting of Fetal-Like Stem Cells in Colorectal Cancer
[Cell Reports] The authors discuss critical mechanisms facilitating the plasticity between stem cell states and highlight the heterogeneity observed upon the appearance of fetal-like states. They focus on therapeutic opportunities that arise by targeting fetal-like colorectal cancer cells and how those concepts can be translated into the clinic.
Knockdown of YTHDF2 Initiates ERS-Induced Apoptosis and Cancer Stemness Suppression by Sustaining GLI2 Stability in Cervical Cancer
[Translational Oncology] Researchers showed how YTH N6-methyladenosine RNA-binding protein F2 (YTHDF2) controlled the fate of cervical cancer cells and whether YTHDF2 could be a valid target for the therapy of cervical cancer.
PA28γ Coordinates the Cross-Talk Between Cancer-Associated Fibroblasts and Tumor Cells to Promote OSCC Progression via HDAC1/E2F3/IGF2 Signaling
[Cancer Letters] Using oral squamous cell carcinoma as a model, the authors demonstrated that PA28γ exhibited high expression in cancer-associated fibroblasts, and its expression significantly correlated with the severity of clinical indicators of malignancy.
Vasorin Promotes Endothelial Differentiation of Glioma Stem Cells via Stimulating the Transcription of VEGFR2
[FASEB Journal] Researchers showed that vasorin (VASN) expression positively correlates with glioma-derived endothelial cell signatures in glioma patients. VASN promotes the endothelial differentiation capacity of glioma stem cell (GSC) in vitro and participates in the formation of GSC-derived vessels in vivo.
Isolation and Phenotypic Characterization of Cancer Stem Cells From Metastatic Oral Cancer Cells
[Oral Diseases] E-cadherin levels were higher in CSC-E cells while vimentin and Slug more produced by CSC-M2 cells. CSC-M1 and CSC-M2 subpopulations showed higher proliferation, produced more colonies, and have stronger adhesion to the extracellular matrix.
Selective Targeting of IRAK1 Attenuates Low Molecular Weight Hyaluronic Acid-Induced Stemness and Non-Canonical STAT3 Activation in Epithelial Ovarian Cancer
[Cell Death & Disease] The authors showed that IRAK1 was upregulated in EOC tissues, and enhanced expression correlates with poorer overall survival.
Platelet-Mediated Circulating Tumor Cell Evasion from Natural Killer Cell Killing via Immune Checkpoint CD155-TIGIT
[Hepatology] Scientists identified CTC-platelet adhesions by single-cell RNA sequencing and multiplex immunofluorescence of blood samples from multiple cancer types.
Oridonin, a Small Molecule Inhibitor of Cancer Stem Cell with Potent Cytotoxicity and Differentiation Potential
[European Journal of Pharmacology] Researchers introduced oridonin, a small molecule with dual differentiation-inducing and cytotoxicity properties capable of eliminating tumor CSCs.
BRG1/BRM Inhibitor Targets AML Stem Cells and Exerts Superior Preclinical Efficacy Combined with BET or Menin Inhibitor
[Blood] Investigators showed that FHD-286 induced differentiation and lethality in AML cells with MLL1 rearrangement or mutant NPM1, concomitantly causing perturbed chromatin accessibility and repression of c-Myc, PU.1, and CDK4/6.
PRMT5-Mediated Methylation of STAT3 Is Required for Lung Cancer Stem Cell Maintenance and Tumor Growth
[Communications Biology] Investigators showed that PRMT5 directly methylated STAT3 and enhances its activated tyrosine phosphorylation in non-small cell lung cancer cells.
Isolation and Characterization of a Novel Mammary Adenocarcinoma, MCa-P1362, with Hormone Receptor Expression, Human Epidermal Growth Factor Receptor 2 Positivity, and Enrichment in Cancer...
[The American Journal Of Pathology] Detailed cellular and molecular characterization was conducted on MCa-P1362, a newly established mouse model of metastatic breast cancer that is syngeneic in BALB/c mice.
Cancer Stem Cell News consolidates the most recent publications covering research areas such as the identification and isolation of cancer stem cells, their proliferation and differentiation characteristics, gene expression and regulatory pathways, and the development of anti-cancer therapies. We also include cancer stem cell jobs and events hosted by leading research organizations, societies, and institutes.
