Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
Cancer Stem Cell News
Cancer Stem Cell News is an online resource that curates the top research publications and reviews about cancer progenitor cells and cancer stem cells.
Multimodal Decoding of Human Liver Regeneration
[Nature] The authors uncovered a novel ANXA2+ migratory hepatocyte subpopulation, which emerged during human liver regeneration, and a corollary subpopulation in a mouse model of acetaminophen-induced liver regeneration.
TLR3 Activation Enhances Abscopal Effect of Radiotherapy in HCC by Promoting Tumor Ferroptosis
[EMBO Molecular Medicine] Scientists demonstrated that subcutaneous administration of Toll-like receptor 3 (TLR3) agonist poly(I:C) could strengthen the abscopal effect during radiotherapy through activating tumor cell ferroptosis signals in bilateral HCC subcutaneous tumor mouse models, which could be significantly abolished by TLR3 knock-out or ferroptosis inhibitor ferrostatin-1.
Expression of Fascin-1 and Its Diagnostic Value in Liver Cancer
[Scientific Reports] Researchers analyzed the expression level of FSCN1 protein in liver cancer tissues and explored its diagnostic and application value in differentiating between HCC and intrahepatic cholangiocarcinom
Kupffer Cell Diversity Maintains Liver Function in Alcohol-Associated Liver Disease
[Hepatology] Scientists used a Western Diet Alcohol mouse model of alcohol-associated liver disease (ALD) to examine the hepatic myeloid cell compartment by scRNA seq and targeted Kupffer cell ablation to understand the diversity and function of liver macrophages in ALD.
Roles and Therapeutic Targeting of Dendritic Cells in Liver Fibrosis
[Journal Of Drug Targeting] The authors describe the process of fibrogenesis, and the phenotypic and functional characteristics of dendritic cells in the liver.
Multimodal Decoding of Human Liver Regeneration
[Nature] The authors uncovered a novel ANXA2+ migratory hepatocyte subpopulation, which emerged during human liver regeneration, and a corollary subpopulation in a mouse model of acetaminophen-induced liver regeneration.
TLR3 Activation Enhances Abscopal Effect of Radiotherapy in HCC by Promoting Tumor Ferroptosis
[EMBO Molecular Medicine] Scientists demonstrated that subcutaneous administration of Toll-like receptor 3 (TLR3) agonist poly(I:C) could strengthen the abscopal effect during radiotherapy through activating tumor cell ferroptosis signals in bilateral HCC subcutaneous tumor mouse models, which could be significantly abolished by TLR3 knock-out or ferroptosis inhibitor ferrostatin-1.
Genetic and Phenotypic Profiling of Single Living Circulating Tumor Cells from Patients with Microfluidics
[Proceedings Of The National Academy Of Sciences Of The United States Of America] Researchers described the nanoplatform for interrogating living cell host-gene and (micro-)environment relationships, that integrates micro- and nanofluidics to enable highly efficient capture of circulating tumor cells from blood samples.
Circadian Regulation of Cancer Stem Cells and the Tumor Microenvironment During Metastasis
[Nature Cancer] The authors review how the circadian clock influences CSCs and their local tumor niches in the context of different stages of tumor metastasis.
Identification of a Set of Genes Potentially Responsible for Resistance to Ferroptosis in Lung Adenocarcinoma Cancer Stem Cells
[Cell Death & Disease] The authors observed that the ferroptosis inducer RSL3 triggered lipid peroxidation and cell death in lung adenocarcinoma cells when grown in 2D conditions; however, when grown in 3D conditions, all cell lines underwent a phenotypic switch, exhibiting substantial resistance to RSL3 and, therefore, protection against ferroptotic cell death.
The CD33xCD123xCD70 Multispecific CD3-Engaging DARPin MP0533 Induces Selective T Cell–Mediated Killing of AML Leukemic Stem Cells
[Cancer Immunology Research] Researchers designed MP0533, a multispecific CD3-engaging designed ankyrin repeat protein that could simultaneously bind to three antigens on AML cells, CD33, CD123, and CD70, aiming to enable avidity-driven T cell–mediated killing of AML cells co-expressing at least two of the antigens.
NAT10-Mediated ac4C Modification Promotes Stemness and Chemoresistance of Colon Cancer by Stabilizing NANOGP8
[Heliyon] The levels of NAT10 in normal colon and chemoresistant colon cancer tissues were determined utilizing quantitative real-time polymerase chain reaction alongside immunohistochemistry.
Cancer Stem Cell News consolidates the most recent publications covering research areas such as the identification and isolation of cancer stem cells, their proliferation and differentiation characteristics, gene expression and regulatory pathways, and the development of anti-cancer therapies. We also include cancer stem cell jobs and events hosted by leading research organizations, societies, and institutes.
