Identification of a Set of Genes Potentially Responsible for Resistance to Ferroptosis in Lung Adenocarcinoma Cancer Stem Cells

The authors observed that the ferroptosis inducer RSL3 triggered lipid peroxidation and cell death in lung adenocarcinoma cells when grown in 2D conditions; however, when grown in 3D conditions, all cell lines underwent a phenotypic switch, exhibiting substantial resistance to RSL3 and, therefore, protection against ferroptotic cell death.