Dermal Cell News

Dermal Cell News is an online resource highlighting the latest research about wound healing, skin disorders, and dermal cancers.

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Hydroxypinacolone 9-cis Retinoate Mitigates UV-Induced Photoaging by Modulating ECM, Fibroblasts, Inflammation, and Melanogenesis

February 12, 2026

[Journal of Investigative Dermatology] Single-cell RNA sequencing and spatial transcriptomics revealed restoration of fibroblast, basal cell, and melanocyte proportions, suppression of myofibroblast differentiation, and upregulation of ECM-related genes.

Dermal Microvascular Responses of Human IPSC-Derived Skin Organoids to Inflammation and Injury

February 12, 2026

[American Journal of Pathology] Reseachers profiled temporal dynamics of human stem cell-derived skin organoid vasculogenesis and interrogated organoid responses to inflammatory and traumatic stimuli.

Plakoglobin Phosphorylation at Serine 665 Is Capable of Stabilizing Cadherin-Mediated Adhesion in Keratinocytes

February 12, 2026

[JCI Insight] Scientists investigated the relevance of plakoglobin phosphorylation at S665 for stabilization of keratinocyte cohesion and further characterized the underlying mechanisms.

miRNA-Driven Cancer Cell Plasticity, Tolerance, and Therapy Resistance: Lessons from Melanoma

February 12, 2026

[Molecular Cancer] Investigators combine current knowledge on phenotypic plasticity, drug-tolerant states, and microenvironmental remodeling, with miRNA regulation.

RIPK4 Function Interferes with Melanoma Cell Adhesion and Metastasis

February 12, 2026

[Molecular Oncology] Using an integrated approach involving clinical samples, in vivo xenograft models, transcriptomic analysis, and 3D functional assays, scientists showed that receptor-interacting protein kinase 4 (RIPK4) deletion significantly reduces pulmonary metastasis formation.

Hair Follicle Organoids Using Human iPSC-Derived Ectodermal Precursor Cells for Hair Regenerative Medicine

February 12, 2026

[ACS Biomaterials Science & Engineering] Researchers aimed to differentiate hiPSCs into hair follicle epithelial and mesenchymal stem cells, and to subsequently purify and use them to generate hair follicle organoids.

Conditioned Medium from Human Adipose-Derived Mesenchymal Stromal Cells Can Modulate Cell Migration and Morphology of Keratinocytes In Vitro

February 3, 2026

[Human Cell] Researchers produced conditioned medium using primary cultures from human adipose-derived MSCs. This medium was used as treatment in a culture of keratinocyte cell line from adult human skin to investigate the modulation of their dynamics.

Wnt-Associated DKK3 in Keratinocytes Mediates Radiation-Induced Hyperplasia, Dermatitis, and Skin Fibrosis

February 2, 2026

[Signal Transduction and Targeted Therapy] To define the function of Dickkopf (DKK) 3 in radiation-induced skin damage, scientists combined complementary in vivo and in vitro approaches, including a 3D human skin model, mice with cell-type-specific Dkk3 deletions, and irradiated human skin specimens.

A MIF-p38-GSDMD Inflammatory Loop in Keratinocytes Underlies UVB-Induced Cutaneous Lupus

February 2, 2026

[Cell Death & Disease] Using single-cell transcriptomics and a lupus-prone mouse model, investigators identified keratinocyte-derived macrophage migration inhibitory factor (MIF) as a key amplifier of cutaneous inflammation through a self-sustaining feedback loop.

Oxygen Self-Sufficient Ir–MnII/III Coordination-Assembled Nanoparticles Evoke Apoptosis and Ferroptosis for Boosting Hypoxic Melanoma Photoimmunotherapy

February 2, 2026

[ACS Nano ] Scientists developed pH-light cascade-responsive nanoparticles via coordination-driven assembly of a two-photon photosensitizer and immunoadjuvant Mn ions.

TuHURA Biosciences Received FDA Orphan Drug Designation for IFx-2.0 for the Treatment of Stage IIB to Stage IV Cutaneous Melanoma

February 2, 2026

[TuHURA Biosciences, Inc.] TuHURA Biosciences, Inc. announced that the US FDA Office of Orphan Products Development has granted Orphan Drug Designation to IFx-2.0 for the treatment of stage IIB to stage IV cutaneous melanoma.

Neoadjuvant Ipilimumab Plus Nivolumab in Melanoma: 5-Year Survival and Biomarker Analysis from the Phase II PRADO-Trial

January 28, 2026

[Nature Medicine] Investigators demonstrate favorable long-term outcomes for patients with an major pathologic responseand identify interferon-gamma and programmed cell death ligand 1 as promising baseline biomarkers.

As the largest organ in the human body, the skin is implicated in a wide range of health conditions. Dermal Cell News is dedicated to covering it all. Our website, newsletter, and Twitter feed highlight research on tissue regeneration in the treatment of skin wounds, burns, cancers, and disorders. We also feature relevant job postings and upcoming events.