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Lgr6-Expressing Functional Nail Stem-Like Cells Differentiated From Human-Induced Pluripotent Stem Cells

May 24, 2024

[PLOS One] Investigators achieved the successful differentiation of nail stem-like cells from human-iPSCs via digit organoids by stepwise stimulation, tracing the molecular processes involved in limb development.

Enhancing Cellular Behavior in Repaired Tissue via Silk Fibroin-Integrated Triboelectric Nanogenerators

May 24, 2024

[Microsystems & Nanoengineering] Scientists presented a flexible silk fibroin-based triboelectric nanogenerator that featured an on-skin substrate and is characterized by excellent skin compliance and air/water permeability.

Transdifferentiation of Fibroblasts Into Muscle Cells to Constitute Cultured Meat with Tunable Intramuscular Fat Deposition

May 23, 2024

[eLife] Researchers employed the myogenic/lipogenic transdifferentiation of chicken fibroblasts in 3D to produce muscle mass and deposit fat into the same cells without the co-culture or mixture of different cells or fat substances.

Establishment of Homotrimer Collagen Type I Signature and Its Association with Clinical Manifestation and Tertiary Lymphoid Structures Formation in Liver Cancer

May 23, 2024

[Heliyon] Using transcriptional and immunoflourance method, investigators established homocol signautre, which was able to transcriptionally and histologically detect homotrimeric collagen type I.

Development of an Alginate–Chitosan Biopolymer Composite With dECM Bioink Additive for Organ-on-a-Chip Articular Cartilage

May 23, 2024

[Scientific Reports] Investigators proposed a novel approach for using a combination of biopolymers and decellularised EC ECM as a bioink additive in the development of scalable organs-on-a-chip using a microfluidic platform.

Gut Microbial Metabolite Targets HDAC3-FOXK1-Interferon Axis in Fibroblast-Like Synoviocytes to Ameliorate Rheumatoid Arthritis

May 23, 2024

[Bone Research] Researchers showed that transplantation of fecal microbiota of collagen-induced arthritis (CIA)-resistant C57BL/6J mice to CIA-susceptible DBA/1J mice confer CIA resistance in DBA/1J mice. C57BL/6J mice and healthy human individuals have enriched B. fragilis than DBA/1J mice and rheumatoid arthritis patients.

DNA Nanoparticle Based 2D Biointerface to Study the Effect of Dynamic RGD Presentation on Stem Cell Adhesion and Migration

May 23, 2024

[Small] In this approach, mesoporous silica nanoparticles were functionalized with single-strand DNA and spin-coated on a glass substrate to create the 2D bio interface.

The β-arrestin1/Endothelin Axis Bolsters Ovarian Fibroblast-Dependent Invadosome Activity and Cancer Cell Metastatic Potential

May 23, 2024

[Cell Death & Disease] The authors identified ET-1 as a pivotal factor in the activation of cancer-associated fibroblasts capable of proteolytic ECM remodeling and the generation of heterotypic spheroids containing cancer cells with a propensity to metastasize.

Cervical Extracellular Matrix Hydrogel Optimizes Tumor Heterogeneity of Cervical Squamous Cell Carcinoma Organoids

May 23, 2024

[Science Advances] Investigators collected para-cancerous cervical tissues from patients diagnosed with cervical squamous cell carcinoma and prepared uterine cervix ECM hydrogels.

Controlled Oxygen Delivery to Power Tissue Regeneration

May 23, 2024

[Nature Communications] Scientists explore the biological relevance of oxygen at both a cellular and tissue level, and the importance of its controlled delivery via engineered biomaterials and devices.

Research Progress in Hydrogels for Cartilage Organoids

May 23, 2024

[Advanced Healthcare Materials] Scientists summarize the methods for establishing cartilage organoids and provide an overview of the advantages and limitations of using matrigel in the cultivation of such organoids.

Theradaptive Secures Landmark Funding from Maryland Stem Cell Research Fund (MSCRF) to Support Human Clinical Trials

May 23, 2024

[Theradaptive, Inc. (PR Newswire)] Theradaptive, Inc. announced it has been awarded funding from the Maryland Stem Cell Research Fund to support human clinical trials for its lead product, OsteoAdapt SP. OsteoAdapt SP is currently in Phase I/II clinical studies for transforaminal lumbar interbody spinal fusion to treat degenerative disc disease, spondylolisthesis, and retrolisthesis.

The Extracellular Matrix News team is proud to provide an essential resource on the latest publications, reviews, industry news, and jobs relevant to the matrix research community. Topics include extracellular matrix-cell interactions, extracellular matrix protein characterization and their application in tissue engineering and regenerative medicine, and the development and characterization of synthetic scaffolds.