The β-arrestin1/Endothelin Axis Bolsters Ovarian Fibroblast-Dependent Invadosome Activity and Cancer Cell Metastatic Potential

The authors identified ET-1 as a pivotal factor in the activation of cancer-associated fibroblasts capable of proteolytic ECM remodeling and the generation of heterotypic spheroids containing cancer cells with a propensity to metastasize.