Hematopoiesis News

Hematopoiesis News is an online resource that provides updates on the latest research in the fields of hematopoiesis, blood, and bone marrow disorders.

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QKI Dysregulation Induces Extensive Splicing Changes in T-Cell Acute Lymphoblastic Leukemia

January 16, 2026

[Haematologica] Researchers investigated the RNA-binding protein Quaking, identifying it as a key regulator of splicing with tumor-suppressive properties in T-ALL.

CRISPR-AuNP: Physicochemical Optimization of a Gold Nanoparticle Platform for Cost-Effective and Modular Non-Viral Gene Editing in HSPCs

January 14, 2026

[Gene Therapy] Researchers advanced a modular, benchtop-assembled gold-polymer hybrid nanoparticle platform that enabled non-viral delivery of multiple CRISPR systems into hematopoietic stem and progenitor cells.

Evaluation of Dual BCL-2/BCL-XL Inhibition in AML Preclinical Models with and without Prior Venetoclax Therapy

January 14, 2026

[Experimental Hematology] Dual BCL-2/BCL-XL inhibitor demonstrated robust activity in AML cell lines and patient-derived models, including activity in samples from patients who relapsed following venetoclax therapy.

Macrophage Ferroptosis in Hematologic Malignancies: Emerging Mechanisms and Therapeutic Implications

January 14, 2026

[Apoptosis] The authors synthesize recent advances in macrophage ferroptosis research to clarify its role in disease pathogenesis.

ER-Diffusion Barriers Exist in Hematopoietic Stem Cell Mitoses, but Are Not Required for Lysosomal Asymmetric Cell Division

January 14, 2026

[Experimental Hematology] Using fluorescence recovery after photobleaching and time-lapse confocal microscopy, scientists observed endoplasmic diffusion barriers in around 30% of mitotic HSCs.

CHEK2 Loss Endows Chemotherapy Resistance to Hematopoietic Stem Cells

January 13, 2026

[Leukemia] Investigators demonstrated that loss of CHEK2 confers resistance to chemotherapy in hematopoietic stem and progenitor cells (HSPCs).

Modulation of the Clonal Burden in Patients with Lower-Risk Myelodysplastic Neoplasms Treated with Imetelstat

January 13, 2026

[Leukemia] The first-in-class, direct, competitive telomerase inhibitor, imetelstat, demonstrated higher rates of red blood cell (RBC) transfusion independence versus placebo in patients with non-del(5q), RBC transfusion-dependent lower-risk myelodysplastic syndromes/neoplasms who were relapsed/refractory to or ineligible for erythropoiesis-stimulating agents in the Phase III IMerge study.

NUP98 Rearrangements in Adult AML Patients: Evaluation of Clinical Implications and Identification of Novel Fusion Partners

January 8, 2026

[Leukemia] Using targeted-capture sequencing, researchers identified 41 cases with NUP98 rearrangements among 1569 AML cases, representing the majority of 44 NUP98-rearranged cases detected across 4753 myeloid neoplasms.

Bone Marrow Failure, Somatic Rescue by P53 Inactivation, and Enhanced Leukemogenesis in Germline ERCC6L2 Disease

January 6, 2026

[Blood] Using novel preclinical in vitro and in vivo model systems, investigators demonstrated that excision repair cross-complementing 6 like 2 (ERCC6L2) maintains the competitive ﬁtness of hematopoietic stem and progenitor cells by mitigating replication stress.

Mutant p53 Promotes Clonal Hematopoiesis through Generating a Chronic Inflammatory Microenvironment

January 6, 2026

[Journal of Clinical Investigation] The authors showed that inflammatory stress confers a competitive advantage to p53 mutant hematopoietic stem and progenitor cells by activating the NLRP1 inflammasome and increasing the secretion of pro-inflammatory cytokines.

Molecular and Phenotypic Blueprint of Human Hematopoiesis Links Proliferation Stress to Stem Cell Aging

January 6, 2026

[Journal of Experimental Medicine] Investigators provided a comprehensive phenotypic, transcriptional, and functional dissection of human hematopoiesis from youth to advanced age.

Shear Stress Governs Hematopoietic Stem Cell Fate to Promote Inflammation-Induced Aging

January 6, 2026

[Nature Aging] Scientists found that PIEZO1 senses shear stress in blood flow to induce HSC proliferation and myelopoiesis.

Hematopoiesis News curates the top publications and reviews covering the regulation, expression patterns, differentiation and characterization of hematopoietic stem cells, as well as blood and bone marrow disorders. We also feature the latest job postings and upcoming conferences in the hematopoiesis field.