Hematopoiesis News

Hematopoiesis News is an online resource that provides updates on the latest research in the fields of hematopoiesis, blood, and bone marrow disorders.

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Compartmentalized Inflammatory Landscape and Macrophage Plasticity Regulate Tet2+/- Mediated Clonal Hematopoiesis

January 20, 2026

[Blood] Leveraging intravital imaging and a murine model of clonal hematopoiesis of indeterminate potential, the authors demonstrated transcriptional and functional compartmentalization of the marrow microenvironment.

Activation of a Branched-Chain Amino Acid Rheostat Restores Replication-Dependent Hematopoietic Stem Cell Fitness

January 20, 2026

[Cell Stem Cell] Researchers found that accrued divisions alter HSC production, generating low-output bone-marrow landscapes that are highly variable in lineage contribution and transcriptionally divergent within individual lineages.

FBXO11 Suppression Rewires an NPM1-Centered Interactome Influencing the Progression of Myelodysplastic Syndrome

January 20, 2026

[Journal of Clinical Investigation] Integration of multiomics data revealed that the SCF-F-box only protein 11 (FBXO11) complex regulates spliceosome and ribosome components in a nucleophosmin 1 (NPM1)-centric network.

CSF1R Marks a Subset of Fetal Hematopoietic Multipotent Progenitor Cells with Acute Myeloid Leukaemia Propagation Properties

January 20, 2026

[Leukemia] Scientists showed that a subset of fetal lymphoid-primed multipotent progenitors expressing the Colony-Stimulating Factor 1 receptor (CSF1R) gives rise to AML upon KMT2A::MLLT3 induction in a mouse model.

CCR5 Marks a Subset of Mouse Hematopoietic Stem Cells That Are Myeloid Primed and Expand with Age

January 20, 2026

[Proceedings of The National Academy of Sciences of The United States of America] Investigators showed that the chemokine receptor CCR5 is mainly expressed on myeloid-biased HSCs, and therefore, the frequency of CCR5⁺ HSCs increases with age.

Piezo1 Dictates K+ Homeostasis through Coordinated Regulation of the Ubiquitin Ligase Kelch-Like 3 in RBCs and the Kidney

January 20, 2026

[Proceedings of The National Academy of Sciences of The United States of America] The authors identified a key interorgan communication pathway that maintains K⁺ homeostasis and suggests Piezo1–KLHL3 signaling as a potential therapeutic target for treating K⁺ imbalance.

Heritable ER Stress Impairs Mitochondrial Metabolism and Maintenance of Hematopoietic Stem Cells after Low-Dose Irradiation

January 20, 2026

[iScience] Scientists showed that HSC exposed to a single 20 mGy dose of irradiation exhibit, when proliferating, oxidative stress, and altered metabolism associated with increased mitochondrial reactive oxygen species and mitochondrial Ca²⁺ overload.

Rora Regulates Hematopoietic Stem Cell Phenotypes and Progression of Chronic Myelogenous Leukemia

January 20, 2026

[The American Journal of Pathology] HasCATs model was developed to identify transcription factors (TFs) that resist HSC aging. This approach revealed RORA as a key aging-negative-associated TF. Rora deletion in HSCs caused aged phenomes and functionally impaired their reconstitutive capacity.

Aging of the Hematopoietic System: Mechanisms, Consequences, and Systemic Interactions

January 20, 2026

[Aging Cell] The authors integrate recent insights into the mechanisms and systemic impacts of hematopoietic aging, reframing it as a modifiable axis of systemic aging.

First Leukaemia Patient Treated with Pioneering Therapy

January 20, 2026

[University College London] A newlywed has become the first NHS patient in England with an aggressive form of leukaemia to have the pioneering CAR-T cell therapy – known as ‘obe-cel’ and marketed as Aucatzyl – developed by University College London researchers.

QKI Dysregulation Induces Extensive Splicing Changes in T-Cell Acute Lymphoblastic Leukemia

January 16, 2026

[Haematologica] Researchers investigated the RNA-binding protein Quaking, identifying it as a key regulator of splicing with tumor-suppressive properties in T-ALL.

CRISPR-AuNP: Physicochemical Optimization of a Gold Nanoparticle Platform for Cost-Effective and Modular Non-Viral Gene Editing in HSPCs

January 14, 2026

[Gene Therapy] Researchers advanced a modular, benchtop-assembled gold-polymer hybrid nanoparticle platform that enabled non-viral delivery of multiple CRISPR systems into hematopoietic stem and progenitor cells.

Hematopoiesis News curates the top publications and reviews covering the regulation, expression patterns, differentiation and characterization of hematopoietic stem cells, as well as blood and bone marrow disorders. We also feature the latest job postings and upcoming conferences in the hematopoiesis field.