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Hematopoiesis News
Hematopoiesis News is an online resource that provides updates on the latest research in the fields of hematopoiesis, blood, and bone marrow disorders.
Menin Inhibition Enhances Graft-Versus-Leukemia Effects by T-Cell Activation and Endogenous Retrovirus Induction in AML
[Blood] Researchers found that beyond this anti-leukemic mechanism, menin-inhibition induces CIITA and MHC-II expression in lysine methyltransferase 2A-rearranged and NPM1-mutated AML cells in vitro and in vivo.
NSUN2 Promotes Leukemogenesis by Ferritin Heavy Chain 1-Mediated Anti-Ferroptosis and Enhancing Global Protein Synthesis in an Mc-Dependent Manner in B-Acute Lymphoblastic Leukemia
[Clinical Epigenetics] Investigators demonstrate that NOP2/Sun RNA methyltransferase family member 2 (NSUN2) facilitates leukemogenesis by increasing FTH1 expression and enhancing global protein synthesis in an 5-methylcytosine-dependent manner.
CAR-T and CAR-NK Cell Therapies in AML: Breaking Barriers and Charting the Future
[Journal of Translational Medicine] The authors synthesize the current landscape of CAR-T and CAR-NK cell therapies for AML, critically evaluate their clinical progress and limitations, and envision future directions to harness cellular immunotherapy as a cornerstone of AML management.
Different Immunotherapeutic Combinations Enhance Specific T Cell Immune Responses against Leukemic Cells, As Well As Leukemic Progenitor Cells, in Acute Myeloid Leukemia
[Leukemia] Scientists identified which leukemia-associated antigen stimulated the largest IFNγ immune response by T cells from AML patients with and without the nucleophosmin 1 mutation and which immunotherapeutic strategy, either alone or in combination with the immune checkpoint anti-PD-1, could enhance immune responses against leukemic cells.
A Unified Multimodal Single-Cell Framework Reveals a Discrete State Model of Hematopoiesis in Mice
[Nature Immunology] Researchers presented a framework that integrates multimodal single-cell analyses with high-dimensional flow cytometry and enables semiautomated enrichment and functional characterization of diverse cell states.
Mapping Early Human Blood Cell Differentiation Using Single-Cell Proteomics and Transcriptomics
[Science] Investigators performed single-cell proteomics by mass spectrometry and scRNA-seq on the human CD34+ hematopoietic stem and progenitor cellb (HSPC) hierarchy and demonstrated that the proteome data resolved HSPC heterogeneity in accordance with accompanying flow cytometry data.
ID2 Suppresses Multiple Myeloma Cell Proliferation by Repressing the Activity of the Transcription Factor TCF3
[Blood Cancer Discovery] By performing a gain-of-function perturbation screen in human multiple myeloma (MM) cell lines, scientists identified the ID genes as putative suppressors of MM cell fitness.
P-Selectin Overexpression Impairs Hematopoietic Stem Cell Homeostasis via Inflammatory Receptor-Mediated Proliferation and Differentiation
[Cell Death & Disease] Using tissue-specific P-selectin (Selp) overexpression models, reserchers demonstrated that chronic Selp elevation disrupts HSC polarity, promotes oxidative stress accumulation, and induces genomic instability.
GABA Produced by Multiple Bone Marrow Cell Types Regulates Hematopoietic Stem and Progenitor Cells
[Stem Cell Reports] The authors reported gamma-aminobutyric acid (GABA) metabolite produced in the bone marrow as a regulator of hematopoietic stem and progenitor cells.
Mutant NPM1 Modulates PDCD4 Ubiquitination Degradation and Facilitates Leukemogenesis
[iScience] Scientists showed that PDCD4 interacts with NPM1. NPM1 mutation results in cytoplasmic localization of mutated protein, NPMc+, which plays critical roles in leukemogenesis.
Harnessing DNA Barcoding to Enhance and Sustain Polyclonality in Gene-Edited Hematopoietic Stem Cells
[Molecular Therapy-Methods & Clinical Development] The authors developed a barcoded AAV6 donor template to precisely monitor the fate of edited hematopoietic stem and progenitor cells following transplantation.
Single-Cell and Bulk Transcriptomics Uncovers PRKD2-Driven Tumor Stemness and Progression in Multiple Myeloma
[Scientific Reports] Bulk RNA-seq from 24 multiple myeloma to 6 matched marrows plus single-cell datasets were analyzed by differential expression, pseudotime, WGCNA, enrichment, immune deconvolution, and GDSC drug screens.
Hematopoiesis News curates the top publications and reviews covering the regulation, expression patterns, differentiation and characterization of hematopoietic stem cells, as well as blood and bone marrow disorders. We also feature the latest job postings and upcoming conferences in the hematopoiesis field.
