Hematopoiesis News

Hematopoiesis News is an online resource that provides updates on the latest research in the fields of hematopoiesis, blood, and bone marrow disorders.

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Treatment Outcome and Efficacy of Desensitization Strategies for Immunized-PTR in Hematological Malignancies before Hematopoietic Stem Cell Transplantation

January 28, 2026

[Bone Marrow Transplantation] Scientists found that immunized-PTR was associated with poor outcomes in hematological malignancies patients after allogeneic hematopoietic stem-cell transplantation transplantation, and desensitization with rituximab and therapeutic plasma exchange achieved favorable outcomes.

Gpr171 Regulates Embryonic Hematopoietic Stem Cell Emergence via ERK1/2 and Notch Signaling

January 28, 2026

[Proceedings of The National Academy of Sciences of The United States of America] Researchers identifed GPR171, a P2Y-family G-protein-coupled receptor, as a critical regulator of vertebrate embryonic HSC specification.

Comparative Analysis of CRISPR-Cas9, Lentiviral Transduction, and Base Editing for Sickle Cell Disease in a Murine Model

January 28, 2026

[Blood Advances] Base editing and lentiviral transduction provided superior outcomes over CRISPR-Cas9–mediated editing in a competitive murine transplantation model

Caring Cross and Boston Children’s Hospital Collaborate to Expand Access to Gene Therapy for Sickle Cell Disease and Beta Thalassemia

January 28, 2026

[Boston Children's Hospital (EurekAlert)] Caring Cross and Boston Children’s Hospital announced a collaboration to provide a sustainable, affordable pathway for patients to access stem cell gene therapies for the treatment of Sickle Cell Disease.

FDA Greenlights First CAR T-Cell Therapy for Marginal Zone Lymphoma

January 28, 2026

[Oncology Nurse Advisor] The FDA has approved Breyanzi® for the treatment of adult patients with relapsed or refractory marginal zone lymphoma who have received at least 2 prior lines of systemic therapy.

Compartmentalized Inflammatory Landscape and Macrophage Plasticity Regulate Tet2+/- Mediated Clonal Hematopoiesis

January 20, 2026

[Blood] Leveraging intravital imaging and a murine model of clonal hematopoiesis of indeterminate potential, the authors demonstrated transcriptional and functional compartmentalization of the marrow microenvironment.

Activation of a Branched-Chain Amino Acid Rheostat Restores Replication-Dependent Hematopoietic Stem Cell Fitness

January 20, 2026

[Cell Stem Cell] Researchers found that accrued divisions alter HSC production, generating low-output bone-marrow landscapes that are highly variable in lineage contribution and transcriptionally divergent within individual lineages.

FBXO11 Suppression Rewires an NPM1-Centered Interactome Influencing the Progression of Myelodysplastic Syndrome

January 20, 2026

[Journal of Clinical Investigation] Integration of multiomics data revealed that the SCF-F-box only protein 11 (FBXO11) complex regulates spliceosome and ribosome components in a nucleophosmin 1 (NPM1)-centric network.

CSF1R Marks a Subset of Fetal Hematopoietic Multipotent Progenitor Cells with Acute Myeloid Leukaemia Propagation Properties

January 20, 2026

[Leukemia] Scientists showed that a subset of fetal lymphoid-primed multipotent progenitors expressing the Colony-Stimulating Factor 1 receptor (CSF1R) gives rise to AML upon KMT2A::MLLT3 induction in a mouse model.

CCR5 Marks a Subset of Mouse Hematopoietic Stem Cells That Are Myeloid Primed and Expand with Age

January 20, 2026

[Proceedings of The National Academy of Sciences of The United States of America] Investigators showed that the chemokine receptor CCR5 is mainly expressed on myeloid-biased HSCs, and therefore, the frequency of CCR5⁺ HSCs increases with age.

Piezo1 Dictates K+ Homeostasis through Coordinated Regulation of the Ubiquitin Ligase Kelch-Like 3 in RBCs and the Kidney

January 20, 2026

[Proceedings of The National Academy of Sciences of The United States of America] The authors identified a key interorgan communication pathway that maintains K⁺ homeostasis and suggests Piezo1–KLHL3 signaling as a potential therapeutic target for treating K⁺ imbalance.

Heritable ER Stress Impairs Mitochondrial Metabolism and Maintenance of Hematopoietic Stem Cells after Low-Dose Irradiation

January 20, 2026

[iScience] Scientists showed that HSC exposed to a single 20 mGy dose of irradiation exhibit, when proliferating, oxidative stress, and altered metabolism associated with increased mitochondrial reactive oxygen species and mitochondrial Ca²⁺ overload.

Hematopoiesis News curates the top publications and reviews covering the regulation, expression patterns, differentiation and characterization of hematopoietic stem cells, as well as blood and bone marrow disorders. We also feature the latest job postings and upcoming conferences in the hematopoiesis field.