Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
Hematopoiesis News
Hematopoiesis News is an online resource that provides updates on the latest research in the fields of hematopoiesis, blood, and bone marrow disorders.
Targeting IL-1/IRAK1/4 Signaling in Acute Myeloid Leukemia Stem Cells following Treatment and Relapse
[Leukemia] The authors presented transcriptome analyses of functionally defined leukemia stem cell populations at diagnosis and relapse, revealing significant alterations in IL-1 signaling.
Nap1L4a Cooperates with Scl/Klf1 to Recruit H2A.Z in Mediating Interactions Among Cis-Regulatory Elements and Transcription Required for Primitive Erythropoiesis in Zebrafish
[Advanced Science] Scientists demonstrated that zebrafish nap1l4a homozygous mutants are more sensitive to hypoxia stress during the early embryonic stage and exhibit impaired primitive erythropoiesis.
Microenvironmental Cell Interactions Are Essential for Sustaining Functionality of Myelofibrosis Malignant Stem Cells
[Blood] To model in vivo cancer stem cell/tumor microenvironment interactions and elucidate their functional consequences, scientists focused on myelofibrosis, a stem cell driven myeloproliferative neoplasm.
Mechanometabolism Instructs Hematopoietic Stem Cell Specification
[Journal of Experimental Medicine] Researchers reported that shear stress triggers adaptation in mitochondrial composition, ultrastructure, and function, which are essential for hematopoietic fate and engraftment potential.
Ribosomal Protein Control of Hematopoietic Stem Cell Transformation through Regulation of Metabolism
[Cell Reports] The authors reported that expression of the ribosomal protein RPL22 is frequently reduced in human myelodysplastic syndrome and AML, and reduced RPL22 expression is associated with worse outcomes.
Coordinated Changes in Stromal and Hematopoietic Cells That Define the Perinatal to Juvenile Transition in the Mouse Thymus
[Cell Reports] Investigators identified age-associated changes in mouse thymic epithelial cells, mesenchyme, endothelium, and hematopoietic antigen-presenting cells from birth to one month of age using single-cell transcriptional profiling, flow cytometry, and imaging.
Downregulated Smad3 Signaling Impairs the Maturation of MO-MDSC in Colorectal Cancer
[Cell Death & Disease] Researchers demonstrated that Smad3 is significantly downregulated in myeloid-derived suppressor cell from colorectal cancer patients and tumor-bearing mouse models, impairing monocytic lineage maturation.
Prpf4 Sequentially Regulates the Expansion and Maturation of Erythrocyte through Distinct Mechanisms
[Cell Death Discovery] Scientists demonstrated that prpf4 sequentially regulates erythrocyte proliferation and maturation during zebrafish definitive hematopoiesis.
Inflammatory Mediators Differentially Regulate Megakaryopoiesis and Thrombopoiesis in Myelofibrosis and Essential Thrombocythemia
[Scientific Reports] The authors investigated the contribution of circulating inflammatory mediators to the abnormalities in the megakaryocytic lineage characteristic of myelofibrosis and essential thrombocythemia.
Venetoclax Plus Azacitidine in Relapsed or Refractory T Cell Acute Lymphoblastic Leukaemia: A Multicentre, Single-Arm, Phase II Trial
[Lancet Haematology] In this single-arm, Phase II, multicenter trial, patients aged 15–70 years with relapsed or refractory T-cell acute lymphoblastic leukemia and an Eastern Cooperative Oncology Group performance status of 0–3 were eligible.
A T Cell Receptor Targeting RUNX1 Frameshift Mutations in Acute Myeloid Leukemia
[Leukemia] Investigators introduced a construct with a RUNX1 frameshift mutation into B-cell lines with common HLA class I alleles and identified 13 neopeptides by immunopeptidomics.
Organoids As a New Approach in Advancing Cancer Therapies for Hematologic Malignancies
[Biochimica Et Biophysica Acta-Reviews On Cancer] Scientists introduce hematologic organoids and how bone marrow, lymph nodes, thymus, and spleen organoids can replicate the hematologic malignancies for personalized therapies and research studies.
Hematopoiesis News curates the top publications and reviews covering the regulation, expression patterns, differentiation and characterization of hematopoietic stem cells, as well as blood and bone marrow disorders. We also feature the latest job postings and upcoming conferences in the hematopoiesis field.
