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Hematopoiesis News
Hematopoiesis News is an online resource that provides updates on the latest research in the fields of hematopoiesis, blood, and bone marrow disorders.
Leveraging the Active Conformation of LFA-1 As a Potential Target for Hematological Malignancies
[Molecular Therapy-Methods & Clinical Development] The authors introduced a novel nano-liposomal delivery system that exploits the overexpressed, open-active conformation of Lymphocyte Function-Associated Antigen-1 (LFA-1) on malignant hematopoietic cells.
Inhibiting Ferroptosis Enhances Ex Vivo Expansion of Human Hematopoietic Stem Cells
[Nature Cell Biology] Scientists showed that HSC loss in existing culture methods is driven largely by ferroptosis, a metabolically regulated, iron-dependent cell-death pathway, and that it can be blocked to augment HSC expansion.
MAFB Regulates Hematopoietic Stem Cell Proliferation and Maintenance
[Scientific Reports] Using Mafb-deficient and Mafb-GFP knock-in mouse models, researchers demonstrated that Mafb deletion enhances proliferation, cell cycle entry, and myeloid differentiation of fetal liver HSCs.
Erythroid Precursors Regulate Local Oxygen Tension and Repair Outcomes in the Bone Marrow Niche
[Proceedings of The National Academy of Sciences of The United States of America] Investigators showed in mice that while the tissue oxygen tension in bone marrow is low, intracellular oxygenation is heterogeneous, and erythroid cells are high in oxygen.
CBX7 Regulates Chemotherapy-Induced Senescence-Like Growth Arrest in Multiple Myeloma via the ERK/STAT3/PIM1 Axis
[Journal of Translational Medicine] Flow cytometry assessed senescence-associated β-galactosidase activity in myeloma cells from bone marrow samples of multiple myeloma patients.
Olutasidenib for Mutated IDH1 Acute Myeloid Leukemia: Final Five-Year Results from the Phase II Pivotal Cohort
[Journal of Hematology & Oncology] 5-year data support the durable efficacy and manageable safety profile of olutasidenib in relapsed/refractory mutant isocitrate dehydrogenase 1 (mIDH1) AML, including heavily pretreated patients.
FDA Approves Ziftomenib for Relapsed or Refractory Acute Myeloid Leukemia with a NPM1 Mutation
[US FDA] The FDA approved ziftomenib, a menin inhibitor, for adults with relapsed or refractory AML with a susceptible nucleophosmin 1 mutation who have no satisfactory alternative treatment options.
CD43, but Not CD41, or GPI-80, Marks First Definitive Hematopoietic Stem Cells in the Human Embryo
[Development] Scientists found that the first definitive HSCs are marked by CD43, but not CD41, similar to the early hematopoietic progenitor cells differentiating in culture from human ES cells
Neutrophil/Leukemia-Tropic Dual-Drug Nanomedicine Potentiates the Treatment of Acute Myeloid Leukemia
[Advanced Materials] Scientists reported a neutrophil/leukemia-tropic polymersome vincristine/volasertib dual-drug nanoformulation to selectively bind to leukemia cells and neutrophils, and to ratiometrically release clinical chemotherapeutics and a polo-like kinase 1 inhibitor, thereby potentiating the treatment of AML.
Metabolic Adaptation of Regenerative Hematopoiesis Depends on Docking-Independent Mitochondrial Connexin 43
[Blood] Through integrated transcriptomic, proteomic, metabolomic, phenotypic, and functional analyses of HSCs and their isolated mitochondria, scientists identified that Cx43 is present on the inner and outer mitochondrial membranes of HSCs/multipotential progenitors.
Venetoclax Plus Gilteritinib Is Effective in Preclinical Models of FLT3-Mutant BCL11B-a Lineage-Ambiguous Leukemia
[Blood] Scientists investigated the efficacy of B-cell lymphoma 2 (BCL-2) and FMS-like tyrosine kinase 3 (FLT3) inhibition with venetoclax and gilteritinib, respectively, in preclinical models of BCL11B-a leukemia.
Setd2 Ensures the Establishment of a Precise Basal Inflammatory State Within Murine Hematopoietic Stem/Progenitor Cells
[Cell Death & Disease] Through integrated single-cell transcriptomic/epigenomic profiling and functional interrogation, the authors identify Setd2-mediated H3K36me3 as an indispensable epigenetic amplifier sustaining baseline inflammation in murine hematopoietic stem/progenitor cells.
Hematopoiesis News curates the top publications and reviews covering the regulation, expression patterns, differentiation and characterization of hematopoietic stem cells, as well as blood and bone marrow disorders. We also feature the latest job postings and upcoming conferences in the hematopoiesis field.
