Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
Hematopoiesis News
Hematopoiesis News is an online resource that provides updates on the latest research in the fields of hematopoiesis, blood, and bone marrow disorders.
Gene Therapy Supports Long-Term Reconstitution of Patient Hematopoietic Stem Cells in Deficiency of Adenosine Deaminase 2
[Molecular Therapy-Methods & Clinical Development] Researchers developed a lentiviral vector to restore adenosine deaminase 2 expression in patient hematopoietic stem and progenitor cells and evaluated its safety and efficacy in preclinical models.
Comparative Analysis of CRISPR-Cas9, Lentiviral Transduction, and Base Editing for Sickle Cell Disease in a Murine Model
[Blood Advances] The authors optimized ex vivo conditions in CD34+ hematopoietic stem and progenitor cells (HSPCs) and infused edited sickle cell disease HSPCs into busulfan-conditioned NBSGW mice.
The Effects of Direct Addition of Lead(Ii) Acetate to a Human In Vitro Model of Hematopoiesis Recapitulates Exposure to Lead In Utero
[Toxicology] Researchers utilized a previously published NAM, which has been shown to develop cells from the myeloid and lymphoid immune lineages.
TGFβ-Activated Kinase-1 Knockdown in Hematopoietic Stem-Progenitor Cells Causes PANoptosis and Myelodysplastic Syndrome-Like Disease in Mice
[Haematologica] Investigators found that TAK1 is required for the survival of hematopoietic stem/progenitor cells by restricting RIPK1 dependent and independent PANoptosis.
Lnk Deficiency Enhances Translesion Synthesis to Alleviate Replication Stress and Promote Hematopoietic Stem Cell Fitness
[Journal of Clinical Investigation] Scientists uncovered a novel role for LNK in regulating translesion synthesis during hematopoietic stem cell replication. Lnk deficiency reduced replication stress-associated DNA damage, particularly in the Fanconi anemia background.
Shikonin Reduces Hematopoietic Stem Cells and Immune Cells in Zebrafish Embryos by Activating the AMPK Signaling Pathway
[International Immunopharmacology] Zebrafish were used as a model organism to systematically investigate the potential effects of shikonin on hematopoiesis and the immune system.
NSUN2 Promotes Leukemogenesis by Ferritin Heavy Chain 1-Mediated Anti-Ferroptosis and Enhancing Global Protein Synthesis in an m5c-Dependent Manner in B-Acute Lymphoblastic Leukemia
[Clinical Epigenetics] Lineage-negative progenitor cells from NOP2/Sun RNA methyltransferase family member 2 (Nsun2) knockout and wild-type mice were used to generate BCR-ABL-driven murine B-acute lymphoblastic leukemia model.
The Hematopoietic Stem Cell MYB Enhancer Is Essential and Recurrently Amplified during T-Cell Leukemogenesis
[Journal of Clinical Investigation] The authors performed a genome-wide CRISPR interference screen of the strongest ETS1-dependent regulatory elements.
Noninvasive Genotyping and Early Disease Dynamics Demonstrate the Efficacy of Ibrutinib in Combination with Immunochemotherapy in Patients with Mantle Cell Lymphoma Treated in the...
[Leukemia] Besides direct anti-B-cell efficacy, ibrutinib improves chemotherapy efficiency by reconstituting an effective immune system and enhancing immune cell control.
Developmental Hematopoiesis: Innate Programming of αβ T Cells
[Experimental Hematology] Scientists discuss the evidence that αβ T cell lineage decisions are not solely determined by thymic selection, and that hematopoietic origin also intrinsically biases development towards innate-like T cells in early life.
ID1 in Hematopoiesis and Hematologic Disorders: Novel Potentials of a Classic Differentiation Regulator
[Cellular & Molecular Biology Letters] The authors comprehensively summarize the expression patterns of inhibitor of DNA binding 1 (ID1) in hematopoietic and stromal cells within the bone marrow niche, and delve into its modulation of blood lineage commitment and development.
Regulating Ferroptosis in Leukemic Stem Cells: From Stemness Preservation to Targeted Differentiation Strategies
[Stem Cell Reviews and Reports] Investigators provide a systematic analysis of leukemic stem cell ferroptosis resistance and explore the interplay between iron metabolism, lipid peroxidation, and antioxidant defense mechanisms.
Hematopoiesis News curates the top publications and reviews covering the regulation, expression patterns, differentiation and characterization of hematopoietic stem cells, as well as blood and bone marrow disorders. We also feature the latest job postings and upcoming conferences in the hematopoiesis field.
