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Hematopoiesis News
Hematopoiesis News is an online resource that provides updates on the latest research in the fields of hematopoiesis, blood, and bone marrow disorders.
Tumors Hijack Macrophages for Iron Supply to Promote Bone Metastasis and Anemia
[Cell] The authors showed that a specialized population of VCAM1+CD163+CCR3+ macrophages, normally essential for erythropoiesis by transporting iron to erythroblasts, are highly enriched in the bone metastatic niche in mouse models.
CUX1 Restrains Latent Hematopoietic Stem Cell Plasticity by Suppressing Stem Cell-Intrinsic Inflammatory Pathways
[Blood] Using novel mouse models and single-cell approaches, researchers reported that dynamic and distinct CUX1 levels are integral to HSC activity.
Platelet Factor 4 (PF4) Regulates Hematopoietic Stem Cell Aging
[Blood] Scientists showed that the age-related alterations of the megakaryocytic niche and associated downregulation of Platelet Factor 4 (PF4) are pivotal mechanisms driving HSC aging.
Nanobioreactor Detection of Space-Associated Hematopoietic Stem and Progenitor Cell Aging
[Cell Stem Cell] Investigators developed bone marrow niche nanobioreactors with lentiviral bicistronic fluorescent, ubiquitination-based cell-cycle indicator reporter for real-time hematopoietic stem and progenitor cell tracking in artificial intelligence-driven CubeLabs.
Targeting O-GlcNAcylated METTL3 Impedes MDS/AML Progression via Diminishing SRSF1 m6a Modification
[Molecular Therapy] Researchers found that methyltransferase-like protein 3 (METTL3) is O-GlcNAcylated in both myelodysplastic syndrome and acute myeloid leukemia, and its expression positively correlates with O-GlcNAcylation levels.
Timing Genomic Antigen Loss in Multiple Myeloma Treated with T-Cell Redirecting Immunotherapies
[Blood Cancer Discovery] By leveraging chemotherapy mutational signatures as temporal barcodes within whole genome sequencing data, the authors timed genomic antigen escape in 4 out of 11 relapsed/refractory multiple myeloma patients.
A Single-Cell Framework Identifies Functionally and Molecularly Distinct Multipotent Progenitors in Adult Human Hematopoiesis
[Cell Reports] Using multi-omic single-cell analyses and functional assays, scientists identified distinct human multipotent progenitors within Lin−CD34+CD38dim/lo adult bone marrow with unique biomolecular and functional properties.
Critical Role of Niche S100A8 for Acute Myeloid Leukemia Progression and Hematopoiesis Regeneration
[Blood Advances] Investigators found that mesenchymal stromal cells (MSCs) had dysregulated expression of the inflammatory cytokine S100A8 in AML. Upregulating S100A8 in MSCs increased the proliferation of AML cells in vitro.
Dual Targeting of CDK6 and LSD1 Is Synergistic and Overcomes Differentiation Blockade in AML
[EMBO Molecular Medicine] Scientists demonstrated that the combined inhibition of CDK6 and LSD1 restores myeloid differentiation and depletes the leukemic progenitor compartment in AML samples.
Hematopoietic Stem and Progenitor Cells As a Reservoir for Trained Immunity
[eLife] The authors summarize the evidence that innate immune memory is epigenetically encoded in hematopoietic stem and progenitor cells.
Exploring the Biology of Lymphoma to Identify New Drug Targets
[University of Miami Miller School of Medicine] Drs. Jonathan Schatz and Hassan Al Ali recently received a four-year, $2.4 million award from the National Cancer Institute to investigate the possibility of treating diffuse large B-cell lymphoma by targeting GAK.
Off-the-Shelf Dual CAR-iNKT Cell Immunotherapy Eradicates Medullary and Leptomeningeal High-Risk KMT2A-Rearranged Leukemia
[Blood] Researchers equip iNKT with CD19- and/or CD133-targeting CARs and investigate their anti-leukamia activity against KMT2A-rearranged acute lymphoblastic leukemia in relevant in vitro and in vivo models.
Hematopoiesis News curates the top publications and reviews covering the regulation, expression patterns, differentiation and characterization of hematopoietic stem cells, as well as blood and bone marrow disorders. We also feature the latest job postings and upcoming conferences in the hematopoiesis field.
