Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
Hematopoiesis News
Hematopoiesis News is an online resource that provides updates on the latest research in the fields of hematopoiesis, blood, and bone marrow disorders.
PI3K/HSCB Axis Facilitates FOG1 Nuclear Translocation to Promote Erythropoiesis and Megakaryopoiesis
[eLife] Investigators identified heat shock cognate B as an indispensable protein for friend of GATA 1 (FOG1) nuclear translocation during erythropoiesis of K562 human erythroleukemia cells and cord-blood-derived human CD34+CD90+HSCs, as well as during megakaryopoiesis of the CD34+CD90+HSCs.
EVIDENCE Meta-Analysis: Evaluating Minimal Residual Disease as an Intermediate Clinical Endpoint for Multiple Myeloma
[Blood] This meta-analysis was based on the FDA guidance for considerations for a meta-analysis of minimal residual disease (MRD) as a clinical endpoint and evaluates MRD-negativity as an early endpoint reasonably likely to predict long-term clinical benefit.
RUNX1 C-terminal Mutations Impair Blood Cell Differentiation by Perturbing Specific Enhancer-Promoter Networks
[Blood Advances] Researchers characterized RUNX1 mutations outside of the runt homology domain. Their analysis of the patient data sets revealed that mutations within the C-terminus frequently occur in hematopoietic disorders.
BRG1/BRM Inhibitor Targets AML Stem Cells and Exerts Superior Preclinical Efficacy Combined with BET or Menin Inhibitor
[Blood] Investigators showed that FHD-286 induced differentiation and lethality in AML cells with MLL1 rearrangement or mutant NPM1, concomitantly causing perturbed chromatin accessibility and repression of c-Myc, PU.1, and CDK4/6.
The Glutaminase Inhibitor CB-839 Targets Metabolic Dependencies of JAK2-Mutant Hematopoiesis in MPN
[Blood Advances] Scientists showed that CB-839 strongly reduced the mitochondrial respiration rate of bone marrow cells from JAK2-V617F mutant mice, demonstrating a marked dependence of these cells on glutamine-derived ATP production.
SDHAF1 Confers Metabolic Resilience to Aging Hematopoietic Stem Cells by Promoting Mitochondrial ATP Production
[Cell Stem Cell] Researchers reported that HSCs acquired metabolic resilience that promoted cell survival. High-resolution real-time ATP analysis with glucose tracing and metabolic flux analysis revealed that old HSCs reprogrammed their metabolism to activate the pentose phosphate pathway.
Biological Relevance of Alternative Splicing in Hematologic Malignancies
[Molecular Medicine] Investigators provide an extensive overview of the biological relevance of aberrant isoforms of genes involved in the regulation of apoptosis, activation of key cellular signaling pathways, and cell metabolism.
DiPersio Receives Innovation Award
[Washington University School of Medicine in St. Loui] John F. DiPersio has received the Chancellor’s Award for Innovation and Entrepreneurship for his research contributions to the field of oncology that are paving the way for novel cancer therapies.
Hyperlipidemia-Induced Hematopoiesis Is Repressed by MLKL in Endothelial Cells of the Splenic Niche
[Nature Cardiovascular Research] Researchers showed unique dysregulated pathways in splenic compared to bone marrow endothelial cells during atherosclerosis, including perturbations of lipid metabolism and endocytic trafficking pathways.
Progresses in Overcoming the Limitations of In Vitro Erythropoiesis Using Human Induced Pluripotent Stem Cells
[Stem Cell Research & Therapy] The authors provide a brief overview of erythropoiesis and examine endeavors to recapitulate erythropoiesis in vitro using various cell sources.
Impact of Busulfan versus Treosulfan Dose Intensity in Myelofibrosis Undergoing Hematopoietic Cell Transplantation
[American Journal of Hematology] This study included 1115 patients receiving first hematopoietic cell transplantation between 2005 and 2021. Patients were generally balanced for key patient characteristics.
An Age-Progressive Platelet Differentiation Path from Hematopoietic Stem Cells Causes Exacerbated Thrombosis
[Cell] The authors revealed a direct differentiation pathway from HSCs into platelets that is progressively propagated upon aging. The aging-enriched platelet path was decoupled from all other hematopoietic lineages, including erythropoiesis, and operated as an additional layer in parallel with canonical platelet production.
Hematopoiesis News curates the top publications and reviews covering the regulation, expression patterns, differentiation and characterization of hematopoietic stem cells, as well as blood and bone marrow disorders. We also feature the latest job postings and upcoming conferences in the hematopoiesis field.
