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Human Immunology News
Human Immunology News is an online publication and email newsletter for researchers studying the human immune system.
Antisense to Human CD39 Dysregulates Immune Metabolism in Inflammatory Bowel Disease
[Cellular & Molecular Immunology] Researchers investigated how CD39-AS affects the function of Tregs and Th17 cells in healthy subjects and inflammatory bowel disease patients.
Clemastine Fumarate Accelerates Accumulation of Disability in Progressive Multiple Sclerosis by Enhancing Pyroptosis
[Journal of Clinical Investigation] Investigators identified pyroptosis as a likely mechanism of central nervous system injury underlying progressing independently of relapse activity even outside of clemastine toxicity.
IL-32-Producing CD8+ Memory T Cells Define Immunoregulatory Niches in Human Cutaneous Leishmaniasis
[Journal of Clinical Investigation] Researchers used spatial cell interaction mapping to identify IL-32–expressing CD8+ memory T cells and Tregs as key components of the indoleamine 2,3-dioxygenase 1/programmed death–ligand 1 niche in Sri Lankan patients with cutaneous leishmaniasis and in patients with distinct forms of dermal leishmaniasis in Brazil and India.
Nivolumab and Relatlimab for the Treatment of Patients with Unresectable or Metastatic Mismatch Repair Proficient Colorectal Cancer
[Clinical Cancer Research] Researchers investigated whether LAG-3/PD-1 inhibition would improve clinical outcomes in a mismatch repair proficient colorectal cancer subset.
Reactivating cGAS-STING Signaling by Targeting SOS1 Enhances Antitumor Immunity in NRAS-Mutant Tumors
[Cancer Research] Analysis of RNA-sequencing data revealed a downregulation of the type I interferon response in NRAS-mutant tumors compared with NRAS wild-type tumors, which was associated with poor prognosis in NRAS-mutant melanoma.
IGM-7354, an Immunocytokine with IL-15 Fused to an Anti-PD-L1 IgM, Induces NK, and CD8+ T Cell-Mediated Cytotoxicity of PD-L1 Positive Tumor Cells
[Cancer Immunology Research] Scientists reported an immunocytokine, IGM-7354, which was designed to bind multiple PD-L1 receptors while trans-presenting a single IL-15/IL-15Rα complex on the joining chain to IL-15Rβγ-expressing cytotoxic natural killer and CD8+ T cells.
Cell Therapy with Human IL-10-Producing ILC2s Enhances Islet Function and Inhibits Allograft Rejection
[American Journal of Transplantation] Investigators explored whether group 2 innate lymphoid cells (ILC2s) that produce IL-10 could enhance islet function and prevent allograft rejection in humanized mouse models of islet transplantation.
Inflammation and IL-4 regulate Parkinson’s and Crohn’s disease associated kinase LRRK2
[EMBO Reports] Scientists described the development of a flow cytometry-based assay to assess leucine-rich repeat protein kinase 2 (LRRK2) activity in individual cells and the generation of an EGFP-Lrrk2 knock-in reporter mouse to analyse cell-specific LRRK2 expression.
KRAS May Facilitate Transformation of Chronic Lymphocytic Leukemia to Histiocytic Sarcoma with Indeterminate Dendritic Cell Features
[American Journal of Clinical Pathology] Scientists investigated the molecular mechanism underlying transformation of chronic lymphocytic leukemia to histiocytic sarcoma with indeterminate dendritic cell features.
The Inactive X Chromosome: A Genetic Driver of Female-Biased Rheumatic Autoimmune Disorders?
[European Journal of Immunology] The authors focus on the experimental evidence suggesting that expression of X-linked genes due to dysregulation in X chromosome inactivation maintenance could contribute to the female predisposition for autoautoimmunity.
Brain Cancer Canada Awards $68,000 Research Grant for Clinical Trial of Anti-Cancer Vaccine Targeting DIPG, the Most Aggressive Pediatric Brain Cancer
[Brain Cancer Canada (Globe Newswire)] Brain Cancer Canada awarded $68,000 for an innovative research initiative led by Dr. Aru Narendran, MD, PhD, and Dr. Patrick Sipila, PhD, at The University of Calgary and Alberta Children’s Hospital.
CXCL12+ Fibroblastic Reticular Cells in Lymph Nodes Facilitate Immune Tolerance by Regulating T Cell-Mediated Alloimmunity
[Journal of Clinical Investigation] Single-cell RNA sequencing of naive and draining lymph nodes (LNs) of heart-transplanted mice and human LNs revealed a specific subset of CXCL12hi fibroblastic reticular cells that expressed high levels of lymphotoxin-β receptor and are enriched in the expression of immunoregulatory genes.
Each issue of Human Immunology News provides up-to-date coverage of the latest news in immunology research performed using human cells or subjects. Our expert editors hand-pick recent research papers and review articles from relevant high-impact peer-reviewed journals on topics including immunotherapy, autoimmunity, adaptive, and innate immunity in humans. We also feature news on clinical trials, award announcements, and funding opportunities.
