Immune Regulation News

Immune Regulation News is an online resource covering research into the regulation, suppression, and modulation of the immune system.

Single-Cell Analysis Reveals Transcriptional Dynamics in Healthy Primary Parathyroid Tissue

[Clinical Cancer Research] The authors investigated the influence of IDH status on the myeloid compartment using human glioma specimens and preclinical models.

Dihydroartemisinin Inhibits Follicular Helper T and B Cells: Implications for Systemic Lupus Erythematosus Treatment

[Archives of Pharmacal Research] In vitro experiments confirmed that dihydroartemisinin DHA inhibited Tfh cell induction and weakened its auxiliary function in B cell differentiation; furthermore, DHA directly inhibited B cell activation, differentiation, and antibody production.

Knockdown of Swine Leukocyte Antigen Expression in Porcine Lung Transplants Enables Graft Survival without Immunosuppression

[Science Translational Medicine] The authors investigated the effect of genetically engineered transplants with permanently down-regulated swine leukocyte antigen expression to prevent rejection in a porcine allogeneic lung transplantation model.

Ezrin, Radixin, and Moesin Are Dispensable for Macrophage Migration and Cellular Cortex Mechanics

[EMBO Journal] To investigate the contributions of the ERM proteins to leukocyte migration, scientists generated single and triple ERM knockout macrophages.

ICOS-Expressing Regulatory T Cells Influence the Composition of Antitumor CTL Populations

[Journal of Immunology] Using an experimental melanoma lung metastasis model, scientists found that Treg cell–specific ICOS knockout reduces the overall tumor burden compared with Cre control mice, with increased CD4+-to-Treg cell and CD8+-to-Treg cell ratios in the tumor.

Wyss Institute Research Collaboration Awarded ARPA-H Agreement to Develop Disease-Agnostic Immunotherapeutic RNA Platform

[Wyss Institute] With the award for up to $27 million from the Advanced Research Projects Agency for Health, a collaborative research project at the Wyss Institute for Biologically Inspired Engineering at Harvard University will advance a disease-agnostic novel RNA therapeutic with the potential to treat diverse diseases, and to be effectively and rapidly deployable.

Cytotoxic T Cells Drive Doxorubicin-Induced Cardiac Fibrosis and Systolic Dysfunction

[Nature Cardiovascular Research] Scientists showed that an aberrant CD8+ T cell immune response following doxorubicin-induced cardiac injury drove adverse remodeling and cardiomyopathy.

Immunomodulator-Derived Nanoparticles Induce Neuroprotection and Regulatory T Cell Action to Alleviate Parkinsonism

[ACS Applied Materials & Interfaces] Investigators explored the neuroprotective efficiency of the immunomodulator and protein phosphatase 2 activator, FTY720 nanoparticles in in vivo experimental Parkinson’s disease models.

PD-1 Regulation of Pathogenic IL-17-Secreting γδ T Cells in Experimental Autoimmune Encephalomyelitis

[European Journal of Immunology] The authors examined the role of PD-1 in regulating γδ T cells in experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosis.

MiR-155-Targeted IcosL Controls Tumor Rejection

[Proceedings of The National Academy of Sciences of The United States of America] Researchers showed that miR-155 targets transcripts encoding IcosL, the ligand for Inducible T-cell costimulator, thus impairing the ability of T cells to recognize and eliminate malignant cells.

The Immunology of Systemic Lupus Erythematosus

[Nature Immunology] Scientists outline the immunological control of systemic lupus erythematosus and looks to experimental tools and approaches that are improving our understanding of the complex contribution of interacting genetics, environment, sex and immunoregulatory factors and their interface with processes inherent to tissue parenchymal cells.

MHC Heterozygosity Limits T Cell Receptor Variability in CD4 T Cells

[Science Immunology] Researchers compared the T cell receptor (TCR) repertoires of naïve CD4 T cells in mice expressing one or two MHC alleles. Unexpectedly, the TCRs in heterozygotes were less diverse that those in the sum of their MHC homozygous relatives.

For over a decade, Immune Regulation News has been keeping the scientific community up-to-date with the latest research and reviews related to immune regulation. Key research areas covered include the roles of regulatory T cells (Treg cells) in autoimmunity and self-reactivity, as well as immune response to disease, transplantation and cancer. We also provide vital updates on the latest jobs and upcoming events in the field of immunology.