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Immune Regulation News
Immune Regulation News is an online resource covering research into the regulation, suppression, and modulation of the immune system.
PKC-θ Is an Important Driver of Fluoride-Induced Immune Imbalance of Regulatory T Cells/Effector T Cells
Scientists explored the mechanism of fluoride interference in the immune system and also identify the key indicators of fluoride-induced immune damage.
[Human Reproduction] AbstractGraphical Abstract
Bevacizumab Induces Ferroptosis and Enhances CD8+ T Cell Immune Activity in Liver Cancer via Modulating HAT1 and Increasing IL-9
Researchers investigated whether and how bevacizumab regulated ferroptosis and immune activity in liver cancer. They performed RNA-sequencing in bevacizumab-treated human liver cancer cell line...
Genetic Polymorphisms in IL-2, IL-10 and FOXP3 Are Associated with Autoimmune Neutropaenia in Early Childhood and Autoantibody Specificity in a Danish Cohort
[Scandinavian Journal Of Immunology] The association between regulatory T cells and autoimmune neutropaenia has been described, and in this study, researchers investigated three Treg-associated genes, IL-2, IL-10, and FOXP3.
Increased Frequencies of Highly Activated Regulatory T Cells Skewed to a T Helper 1-Like Phenotype With Reduced Suppressive Capacity in Dengue Patients
[mBio] Scientists defined in detail the phenotype and function of different regulatory T cell subsets and their association with disease severity in a cohort of acute dengue virus -infected Cambodian children.
Low Serum Apolipoprotein A1 Impairs Antitumor Immunity of CD8+ T Cells via the HIF-1α–Glycolysis Pathway
[Cancer Immunology Research] CD8+ T cell depletion experiments confirmed that ApoA1 exerted its antitumor activity in a CD8+ T cell–dependent manner. In vitro experiments showed that the ApoA1 mimetic peptide L-4F directly potentiated the antitumor activity of CD8+ T cells via a HIF-1α–mediated glycolysis pathway.
Ganoderma lucidum Spores-Derived Particulate β-Glucan Treatment Improves Antitumor Response by Regulating Myeloid-Derived Suppressor Cells in Triple-Negative Breast Cancer
[International Journal Of Biological Macromolecules] Gemcitabine treatment alone altered the tumor microenvironment, including a reduction in antitumor T cells and a rise in myeloid-derived suppressor cells and regulatory T cells.
Icosagen and Lead Discovery Center Announce Collaboration to Discover Novel Monoclonal Antibodies
[Icosagen] Icosagen announced a strategic partnership on selected projects with Lead Discovery Center GmbH. This alliance is focused on the discovery of monoclonal antibody portfolios targeting therapeutically relevant proteins, including a pivotal G-protein coupled receptor, which is often challenging to address.
NF-κB Factors Cooperate with Su(Hw)/E4F1 to Balance Drosophila/Human Immune Responses via Modulating Dynamic Expression of miR-210
[Nucleic Acids Research] Scientists confirmed that the conserved miRNA miR-210 negatively regulated innate immune responses of Drosophila and human via targeting Toll and TLR6, respectively.
A Novel Macrophage Subpopulation Conveys Increased Genetic Risk of Coronary Artery Disease
[Circulation Research] Researchers utilized single-cell RNA-seq and single-cell multiomics approaches in primary human monocyte–derived macrophages to explore the transcriptional regulatory network involved in a critical pathogenic event of coronary atherosclerosis—the formation of lipid-laden foam cells.
HMGB1: A New Target for Ischemic Stroke and Hemorrhagic Transformation
[Translational Stroke Research] The authors summarize the structure and redox properties, secretion and pathways, regulation of immune cell activity, the role of pathophysiological mechanisms in stroke, and hemorrhage transformation for high-mobility group box 1 (HMGB1), which will pave the way for developing new neuroprotective drugs, reduction of post-stroke neuroinflammation, and expansion of thrombolysis time window.
Bispecific Antibody Takes a BiTE Out of B Cells in Rheumatoid Arthritis
[Nature] Amgen’s B-cell-depleting therapy blinatumomab (Blincyto) showed signs of efficacy in rheumatoid arthritis, found an academic-sponsored pilot trial of the CD19xCD3 bispecific T-cell engager (BiTE) in six patients with the autoimmune disease.
Valrubicin-Loaded Immunoliposomes for Specific Vesicle-Mediated Cell Death in the Treatment of Hematological Cancers
[Cell Death & Disease] Following the transplantation of human pediatric B-cell acute lymphoblastic leukemia, T-cell acute lymphoblastic leukemia, or acute myeloid leukemia in immunodeficient NSG mice, investigators generated patient-derived xenograft models, which were treated with valrubicin-loaded immunoliposomes loaded with antibodies to target CD19, CD7 or CD33.
For over a decade, Immune Regulation News has been keeping the scientific community up-to-date with the latest research and reviews related to immune regulation. Key research areas covered include the roles of regulatory T cells (Treg cells) in autoimmunity and self-reactivity, as well as immune response to disease, transplantation and cancer. We also provide vital updates on the latest jobs and upcoming events in the field of immunology.
