HMGB1: A New Target for Ischemic Stroke and Hemorrhagic Transformation

The authors summarize the structure and redox properties, secretion and pathways, regulation of immune cell activity, the role of pathophysiological mechanisms in stroke, and hemorrhage transformation for high-mobility group box 1 (HMGB1), which will pave the way for developing new neuroprotective drugs, reduction of post-stroke neuroinflammation, and expansion of thrombolysis time window.