HMGB1: A New Target for Ischemic Stroke and Hemorrhagic Transformation

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The authors summarize the structure and redox properties, secretion and pathways, regulation of immune cell activity, the role of pathophysiological mechanisms in stroke, and hemorrhage transformation for high-mobility group box 1 (HMGB1), which will pave the way for developing new neuroprotective drugs, reduction of post-stroke neuroinflammation, and expansion of thrombolysis time window.
[Translational Stroke Research]
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