Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
Immunology of Infectious Disease News
Immunology of Infectious Disease News is an online resource dedicated to covering the latest research and developments in the field of infectious diseases.
Subscribe|Follow Us On
Single-Cell Multi-Omic Landscape Reveals Anatomical-Specific Immune Features in Adult and Pediatric Sepsis
[Nature Immunology] Researchers applied multi-omic profiling to analyze peripheral blood mononuclear cells and plasma from 281 adult and pediatric individuals with sepsis and controls.
Macrophage MR1 Antigen Presentation Promotes MAIT Cell Immunity and Lung Microbiota Modulation
[Science] Depletion of MHC class I-related protein 1 (MR1) in macrophages, dendritic cells, and monocytes changed the composition of the microbiota and impaired mucosal associated invariant T (MAIT) cell responses against bacterial infection.
ARCN1 Suppresses Innate Immune Responses against Respiratory Syncytial Virus by Promoting STUB1-Mediated IKKε Degradation
[PLoS Pathogens] Researchers demonstrated that archain 1 (ARCN1) suppresses the anti-Respiratory syncytial virus innate immune response by promoting E3 ubiquitin ligase STUB1-mediated K48-linked polyubiquitination and subsequent proteasomal degradation of IKKε.
Rroid2 Regulates Effector-to-Memory CD8+ T Cell Differentiation during Infection In Vivo
[Proceedings of the National Academy of Sciences of the United States of America] The authors performed deep RNA-seq to map the lncRNA expression landscape of CD8+ T cell subsets during infection and generated lncRNA knockout mouse models to evaluate the in vivo relevance of six lncRNAs.
Interferon-Mediated NK Cell Activation Increases Cytolytic Activity against T Follicular Helper Cells and Limits Antibody Response to SARS-CoV-2
[Nature Immunology] Researchers found that, in ancestral severe acute respiratory syndrome coronavirus 2 infection, individuals with the broadest neutralization profile had fewer NK cells that expressed inhibitory and immaturity markers, whereas NK cells from narrow neutralizers were highly activated and expressed interferon-stimulated genes.
CD8+ T Cell Stemness Precedes Post-Intervention Control of HIV Viremia
[Nature] Scientists mapped and functionally profiled CD8+ T cell responses to autologous HIV epitopes using longitudinal samples from four analytical treatment interruption trials in broadly neutralizing anti-HIV-1 antibody recipients.
Orphan Broadly RBD-Binding Antibodies Annotate Three Remaining Conserved RBD Epitopes along SARS-CoV-2 Evolution
[Nature Communications] Using a heterogeneous double-bait single B-cell sorting strategy, investigators identified a subset of antibodies with broad-spectrum receptor-binding domain (RBD) binding, including recognition of SARS-CoV-1 and emerging variants such as EG.5.1, BA.2.86, JN.1, and KP.2/3.
Conserved CD8 T Cell Vaccines without B Cell Epitopes Drive Robust Protection against SARS-CoV-2 That Is Enhanced by Intranasal Boost
[Science Advances] Researchers identified both Omicron BA.1–specific and ancestral–conserved CD8 T cell epitopes in the SARS-CoV-2 spike protein and evaluated them as carrier-protein fusion vaccines in mouse models.
Mucosal Viral Infection Elicits Long-Lived IgA Responses via Type 1 Follicular Helper T Cells
[Cell] Scientists showed that rotavirus infection induces gut-resident long-lived plasma cells that produce highly mutated, protective immunoglobulin A (IgA).
Toxoplasma Effector TgROP1 Establishes Membrane Contact Sites with the Endoplasmic Reticulum during Infection
[Nature Microbiology] Using a fluorescence sensor and CRISPR-based loss-of-function screening, together with imaging and proteomics, scientists identified the parasite effector mediating membrane contact sites between host endoplasmic reticulum and the vacuole containing the intracellular parasite Toxoplasma gondii.
Rroid2 Regulates Effector-to-Memory CD8+ T Cell Differentiation during Infection In Vivo
[Proceedings of The National Academy of Sciences of The United States of America] The authors performed deep RNA-seq to map the lncRNA expression landscape of CD8+ T cell subsets during infection and generated lncRNA knockout mouse models to evaluate the in vivo relevance of six lncRNAs.
Mpox Virus OPG175 Negatively Regulates Viral Replication via Controlling Wnt Signaling
[iScience] Scientists investigated whether they can distinguish between clades by focusing on the expression of Mpox virus genes.
Immunology of Infectious Disease News was founded to keep the scientific community current with the latest developments in infectious disease research. We feature high-impact publications, news, jobs, and events focused on immune responses to and the development of treatments for infectious diseases such as COVID-19, HIV, hepatitis, tuberculosis, influenza, and malaria.
