Investigators showed that the envelope protein of Zika virus was polyubiquitinated by the E3 ubiquitin ligase TRIM7 through Lys63-linked polyubiquitination.
IgG responses were detected in most patients in both severe and mild groups at nine days post onset and remained high level throughout the study. Antibodies cross-reactive to SARS-CoV and SARS-CoV-2 were detected in COVID-19 patients but not in MERS patients.
[Journal of Clinical Investigation]
The new director of the National Science Foundation (NSF), Sethuraman “Panch” Panchanathan, is familiar with the dark clouds over the agency. His boss, President Donald Trump, keeps proposing big cuts to NSF’s budget. Two recent executive orders on immigration make it harder for foreign scientists—who make up a sizeable share of the U.S. research enterprise—to enter the country.
The apparent speed at which an Indian government agency aims to test and approve a homegrown COVID-19 vaccine has created an uproar among scientists both in India, which is increasingly overwhelmed by the new coronavirus, and abroad.
By characterizing a measles virus-specific but paramyxovirus cross-reactive human T cell clone, investigators discovered a highly conserved HLA-B*1501-restricted T cell epitope in the fusion protein.
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Scientists demonstrated that human peripheral blood and hepatic MAIT and iNKT cells expressed surprisingly high levels of CD150, more than any other lymphocyte subsets, including central and effector memory T-cells.
[Journal of infectious Diseases]
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Investigators report that mice harboring a serine 365-to-alanine mutation in The Stimulator of Interferon Genes (STING) were unexpectedly resistant to Herpes Simplex Virus (HSV)-1, despite lacking STING-induced type I IFN responses.
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The authors showed that Rhesus macaques were susceptible to the infection by SARS-CoV-2. Histopathological observation showed that SARS-CoV-2 infection could cause interstitial pneumonia in animals, characterized by hyperemia and edema, and infiltration of monocytes and lymphocytes in alveoli.
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In mid-March, as businesses and universities across Europe were shutting down in a bid to slow the COVID-19 pandemic, three longtime friends were talking about how they wished they could do something to combat the disease.
In this pandemic, R has leapt from the pages of academic journals into regular discussions by politicians and newspapers, framed as a number that will shape everyone’s lives.
AIDS 2020, the 23rd International AIDS Conference, is but one of slews of scientific meetings that have been upended by COVID-19 and gone online.