HIV Induces Airway Basal Progenitor Cells to Adopt an Inflammatory Phenotype

Researchers hypothesized that HIV induced the basal stem/progenitor cells to express inflammatory mediators that contributed to the pathogenesis of emphysema.
[Scientific Reports]
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A Genetically Stable Zika Virus Vaccine Candidate Protects Mice against Virus Infection and Vertical Transmission

The authors generated a Zika virus mutant, ZE4B-36, which combined mutations in both E glycosylation and NS4B P36.
[npj Vaccines]
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Human Neutralizing Antibodies against SARS-CoV-2 Require Intact FC Effector Functions for Optimal Therapeutic Protection

Scientists defined correlates of protection of neutralizing human monoclonal antibodies in SARS-CoV-2-infected animals.
[Cell]
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Common Genetic Variation in Humans Impacts In Vitro Susceptibility to SARS-CoV-2 Infection

Researchers applied human induced pluripotent stem cell-based models and CRISPR-engineering to explore the host genetics of SARS-CoV-2.
[Stem Cell Reports]
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COVID-19 and the Human Innate Immune System

Scientists provide a conceptual framework for the interaction of the human innate immune system with SARS-CoV-2 to link the clinical observations with experimental findings that have been made during the first year of the pandemic.
[Cell]
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ImmunityBio and NantKwest Announce FDA Authorization to Study hAd5 T-Cell COVID-19 Vaccine for Combination of Subcutaneous, Oral and Sublingual Boost to Induce T-Cell, Mucosal, and Antibody Immunity

ImmunityBio, Inc. and NantKwest, Inc. announced they have received FDA authorization to expand Phase I testing of a bivalent hAd5 T-cell COVID-19 vaccine.
[ImmunityBio, Inc. (BusinessWire, Inc)]
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Takeda’s Maribavir Phase III Clinical Trial Met Primary Endpoint of Superiority to Conventional Antiviral Therapy in Transplant Recipients with Refractory, with or without Resistance, Cytomegalovirus Infection/Disease

Takeda Pharmaceutical Company Limited announced new, late-breaking Phase III data from the TAK-620-303 trial, for the investigational drug TAK-620 which met its primary endpoint of superiority compared to conventional antiviral therapies in transplant recipients with refractory, with or without resistance, cytomegalovirus infection/disease.
[Takeda Pharmaceutical Company Limited (BusinessWire, Inc)]
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Post-exposure Protection of SARS-CoV-2 Lethal Infected K18-hACE2 Transgenic Mice by Neutralizing Human Monoclonal Antibody

Scientists characterized and further evaluated the recently identified human monoclonal MD65 antibody for its ability to provide protection against a lethal SARS-CoV-2 infection of K18-hACE2 transgenic mice.
[Nature Communications]
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Diversity and Dynamism of IgA−microbiota Interactions

The authors summarize evidence for the host, bacterial and environmental factors that influence IgA–microbiota interactions.
[Nature Reviews Immunology]
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COVID-19 Immune Signatures Reveal Stable Antiviral T Cell Function despite Declining Humoral Responses

The role of SARS-CoV-2-specific T cell immunity, its relationship to antibodies, and pre-existing immunity against endemic coronaviruses (huCoV), which has been hypothesized to be protective, were investigated in healthy donors, recovered, and active COVID-19 patients.
[Immunity]
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Atypical B Cells Are Part of an Alternative Lineage of B Cells That Participates in Responses to Vaccination and Infection in Humans

Researchers used single-cell RNA sequencing to examine the diversity of both antigen-specific and total B cells in healthy subjects and malaria-exposed individuals.
[Cell Reports]
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