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Mesenchymal Cell News
Mesenchymal Cell News is an online resource that delivers updates on the latest research in the mesenchymal stem cell field.
Single Cell RNA Analysis Uncovers the Cell Differentiation and Functionalization for Air Breathing of Frog Lung
[Communications Biology] Using single-cell RNA sequencing, investigators identified 13 cell types in the developing lungs of a land-dwelling frog. They elucidated the differentiation trajectories and mechanisms of mesenchymal cells, identifying five cell fates and their respective driver genes.
Payload-Delivering Engineered γδ T Cells Display Enhanced Cytotoxicity, Persistence, and Efficacy in Preclinical Models of Osteosarcoma
[Science Translational Medicine] The authors presented an immunotherapeutic platform technology built around the innate properties of the Vγ9Vδ2 T cell, harnessing specific characteristics of this cell type and offering an allocompatible cellular therapy that recruited bystander immunity.
Targeting Nerve Growth Factor-Mediated Osteosarcoma Metastasis: Mechanistic Insights and Therapeutic Opportunities Using Larotrectinib
[Cell Death & Disease] Scientists investigated the influence of nerve growth factor on the migration and metastasis of osteosarcoma patients as well as the underlying molecular mechanisms, based on RNA-sequencing and gene expression data from a public database.
Clinical Implications and Molecular Features of Extracellular Matrix Networks in Soft Tissue Sarcomas
[Clinical Cancer Research] Proteomic and clinical data from 321 patients across 11 histological subtypes were analyzed to define ECM and integrin adhesion networks. Subgroup analysis was performed in leiomyosarcomas, dedifferentiated liposarcomas and undifferentiated pleiomorphic sarcomas.
CCR5-Overexpressing Mesenchymal Stem Cells Protect Against Experimental Autoimmune Uveitis: Insights from Single-Cell Transcriptome Analysis
[Journal of Neuroinflammation] Scientists employed scRNA-seq, RNA-seq and various molecular and cellular approaches to characterize mouse models of classical experimental autoimmune uveitis (EAU), revealing that EAU causes broad retinal neuron degeneration and marker downregulation, and that Müller glia may act as antigen-presenting cells.
Mesenchymal Stromal Cells Dampen Trained Immunity in House Dust Mite-Primed Macrophages Expressing Human MIF Polymorphism
[Cytotherapy] The authors investigated the ability of MSCs to modulate migration inhibitory factor-driven trained immunity both in vitro and in vivo.
Overexpression of NDNF Improves the Cytoprotective Effects of Aged Human Bone Marrow Mesenchymal Stem Cells by Modulating Oxidative Stress and Apoptosis
[Stem Cells and Development] Researchers investigated whether NDNF over-expression improves the protective effect of aged stem cells for injured cardiomyocytes and explore the underlying mechanism.
Patterning and Folding of Intestinal Villi by Active Mesenchymal Dewetting
[Cell] Investigators found that PDGFRA+ subepithelial mesenchymal cells generated myosin II-dependent forces sufficient to produce patterned curvature in neighboring tissue interfaces.
Ganglioside SSEA-4 in Ewing Sarcoma Marks a Tumor Cell Population with Aggressive Features and Is a Potential Cell-Surface Immune Target
[Scientific reports] Among paired subpopulations of tumor cells with low versus high SSEA-4 expression, SSEA-4high expression was significantly and consistently associated with functional characteristics of tumor aggressiveness, including higher cell proliferation, colony formation, chemoresistance and propensity to migrate.
TBX3 Transfection and Nodal Signal Pathway Inhibition Promote Differentiation of Adipose Mesenchymal Stem Cell to Cardiac Pacemaker-Like Cells
[Stem Cell Research & Therapy] The transfection of TBX3 plasmid was carried out using lipofectamine, and inhibition of the nodal signal pathway was done using the small-molecule SB431542. The morphology of the cells was observed using a light microscope.
Human Umbilical Cord Mesenchymal Stromal Cell-Derived Extracellular Vesicles Induce Fetal Wound Healing Features Revealed by Single-Cell RNA Sequencing
[ACS Nano] Researchers utilized single-cell RNA sequencing to investigate the impact of human umbilical cord MSC-derived extracellular vesicles on the cutaneous wound microenvironment in mice.
Single-Cell Sequencing Advances in Research on Mesenchymal Stem/Stromal Cells
[Human Cell] Single-cell sequencing technology emerges as a powerful tool to address these challenges, offering precise dissection of complex cellular samples. It uncovers the genetic structure and gene expression status of individual contained cells on a massive scale and reveals the heterogeneity among these cells.
Mesenchymal Cell News covers topics such as the isolation, identification, and culturing conditions of mesenchymal stem cells, as well as their cellular characterization, behavior and differentiation capacities. We also include research that focuses on identifying tissue sources of mesenchymal stem cells and their potential therapeutic applications in regenerative medicine and cellular therapies.
