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Mesenchymal Cell News
Mesenchymal Cell News is an online resource that delivers updates on the latest research in the mesenchymal stem cell field.
GPX8 Is Transcriptionally Regulated by KLF16 and Promotes Osteosarcoma Progression
[Journal of Translational Medicine] Researchers demonstrated that glutathione peroxidase 8 (GPX8) is a critical oncogene in osteosarcoma progression and that its expression is regulated by kruppel‑like factor 16 (KLF16).
Cx43 Hemichannel-Mediated Paracrine Involves in the Promotion of MSCs on Skin Wound Healing
[Stem Cell Research & Therapy] The authors established a full-thickness skin wound model in mice to investigate the role of Cx43 hemichannels in MSC-mediated wound healing.
The Fibroblast Epigenome Underlies SS18::SSX-Mediated Transformation in Synovial Sarcoma
[Nature Communications] Scientists employed a MSC specific CreERT2 line to express SS18::SSX in fibroblasts and related cell types, resulting in 100% penetrant synovial sarcoma development in mice. Murine tumours exhibited high concordance with human synovial sarcoma subtypes at the histological and molecular levels.
Engineering CCR2/IFN-γ Overexpression in Enucleated Mesenchymal Stem Cells Enhances Therapy for Rheumatoid Arthritis
[Communications Biology] Investigators generated enucleated human umbilical cord-derived MSCs overexpressing CCR2 and IFN-γ, which retained essential organelles and exhibited immune regulatory, paracrine, and homing capabilities.
Mapping the Tissue-of-Origins of Mesenchymal Stromal Cells in Injury Repair
[Advanced Science] The authors generated a suite of genetic tools to distinguish MSCs between tissues, and to map their fate in local, proximate, and distal organ repair.
Mitochondrial Dysfunction in Mesenchymal Stem Cells Impairs Osteogenesis in Radiation-Induced Bone Injury via Ca2+-NFATc1-Fis1 Pathway
[Cell Death & Disease] The authors revealed the critical role of Fis1 in regulating mitochondrial dynamics and MSC osteogenesis in radiation-induced bone injury.
mRNA Engineering of Allogeneic Mesenchymal Stem Cells Enables Coordinated Delivery of T Cell Engagers and Immunotherapeutic Cues
[Nature Biomedical Engineering] Researchers used mRNA engineering to create an off-the-shelf immunotherapy that they termed DC-25. DC-25 consists of a mesenchymal stem cell armed with three designed mRNA constructs.
Few-Layered Conductive Graphene Foams for Electrical Transdifferentiation of Mesenchymal Stem Cells Into Schwann Cell-Like Phenotypes
[Advanced Healthcare Materials] Scientists demonstrated that MSCs cultured within 3D graphene foams can be transdifferentiated into Schwann cell-like phenotypes using the synergistic effects of electrical stimulation and 3D porous and conductive structure.
Mesenchymal Stem Cell Therapy for End-Stage Liver Disease: Adversity and Opportunity
[Stem Cell Research & Therapy] Among the five types of stem cells that have been experimentally applied to liver diseases, MSCs have emerged as the most extensively studied, with the largest number of experimental and clinical research platforms worldwide.
Longeveron Granted Canadian Patent for Method of Using Stem Cells to Treat Non-Ischemic Dilated Cardiomyopathy and Aging-related Frailty in Patients with Inflammaging
[Longeveron, Inc. (The Canada Finance Journal)] Longeveron, Inc. announced that the Canadian Intellectual Property Office has granted a patent covering administration of laromestrocel for the treatment of patients with symptoms of aging-related frailty and also for the treatment of non-ischemic dilated cardiomyopathy.
PDGF-BB Inhibits F-Actin Formation and Chondrocyte Dedifferentiation in Osteoarthritis via Oxygen-Dependent HIF-1α/SCIN Regulation and RhoA/ROCK Signaling Inhibition
[European Journal of Pharmacology] Scientists investigated the therapeutic potential of platelet-derived growth factor (PDGF)-BB, delivered via sodium hyaluronate, in modulating osteoarthritis chondrocyte microstructure and cytoskeletal dynamics.
Mesenchymal Stromal Cells Engineered with ACE2 for Treatment of Receptor-Mediated Viral Lung Injury
[Molecular Therapy] Scientists engineered MSCs expressoing human ACE2, designed to couple direct antiviral activity with immonoregulation.
Mesenchymal Cell News covers topics such as the isolation, identification, and culturing conditions of mesenchymal stem cells, as well as their cellular characterization, behavior and differentiation capacities. We also include research that focuses on identifying tissue sources of mesenchymal stem cells and their potential therapeutic applications in regenerative medicine and cellular therapies.
