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Mesenchymal Cell News
Mesenchymal Cell News is an online resource that delivers updates on the latest research in the mesenchymal stem cell field.
TRIM37-PARP1-TET1 Axis Maintains Stemness and Prevents Osteoporosis by Inhibiting DNMT1 Alternative Splicing via 5hmc Regulation
[Nature Communications] Scientists revealed 5hmC levels positively regulate MSC self-renewal and osteoblast differentiation.
Embryonic Lineage-Specific iPSC-Derived Mesenchymal Stem/Stromal Cells Exhibit Different Morphology and Intrinsic Functions
[iScience] The authors generated MSCs from human iPSCs via five lineage-specific routes: cranial neural crest, trunk neural crest, paraxial mesoderm, lateral plate mesoderm, and limb mesenchyme.
Dinutuximab Beta Effectively Treats Ewing Sarcoma When Combined with Chemotherapy
[iScience] Through in vitro and in vivo approaches, scientists demonstrated that Dinutuximab beta effectively suppressed tumor growth by 60% and improved survival rate by 68% in a mouse model xenograft.
Hierarchical Therapeutic Potential in the Mesenchymal Stem Cell Landscape
[Journal of Translational Medicine] The authors review the preclinical and clinical advancements in the understanding of the therapeutic properties of MSCs and their subpopulations, assessing the evidence supporting their use in regenerative medicine.
Low Dose IFNγ Remodels Enhancer Landscape to Potentiate Mesenchymal Stromal Cell Activation
[Stem Cell Research & Therapy] Scientists demonstrated that low dose interferon gamma (IFNγ) was sufficient to modulate the transcriptional and epigenetic landscape of MSCs by selectively altering enhancer landscape.
Modulating iMSC Spheroid Function with Mechanically Tunable Hydrogels to Strengthen the Bone-Muscle Axis
[ACS Biomaterials Science & Engineering] Scientists developed a gelatin-based hydrogel system with tunable stiffness to guide spheroids formed from iPSC-derived mesenchymal stromal cells (iMSCs) for simultaneous muscle and bone repair.
Human Umbilical Cord-Derived Mesenchymal Stem Cells Ameliorate Non-Alcoholic Fatty Liver Disease via Activating TFEB-Mediated Autophagy in Male Mice
[Stem Cell Research & Therapy] Human umbilical cord-derived MSCs decreased hepatic lipid content and alanine aminotransferase/aspartate aminotransferase levels, as well as attenuated inflammation and fibrosis in choline-deficient high-fat diet-induced non-alcoholic fatty liver disease mice.
First Patient in Arizona Treated with New Immune-Cell Therapy at HonorHealth Research Institute
[HonorHealth Research Institute (EurekAlert)] A patient with synovial sarcoma, a soft-tissue cancer that usually occurs in the large joints of the arms and legs, is the first in Arizona treated with a new immune-cell-therapy known as TECELRA at the HonorHealth Research Institute.
Neonatal Bone Marrow Interstitial Fluid Supports Expansion and Osteogenic Ability of Human Bone Marrow Mesenchymal Stromal Cells
[Bone Research] Scientists reported the role of neonatal bovine bone marrow interstitial fluid in enhancing the bone regeneration capacity of human bone marrow MSCs.
Device Encapsulated MSCs for Adaptive Secretome Therapy to Effectively Target Ischemic Heart Injury
[Stem Cell Research & Therapy] Scientists highlighted a clinically viable, minimally invasive method for sustained cardioprotection, harnessing the MSC secretome to address a gap in current treatments for ischemic heart disease.
Research Progress on the Role of Mesenchymal Stem Cells in Pyroptosis in Sepsis
[Stem Cell Research & Therapy] MSCs, known for their anti-inflammatory, immunomodulatory, and tissue-regenerative capacities, have attracted attention as a promising therapeutic approach for sepsis.
GPX8 Is Transcriptionally Regulated by KLF16 and Promotes Osteosarcoma Progression
[Journal of Translational Medicine] Researchers demonstrated that glutathione peroxidase 8 (GPX8) is a critical oncogene in osteosarcoma progression and that its expression is regulated by kruppel‑like factor 16 (KLF16).
Mesenchymal Cell News covers topics such as the isolation, identification, and culturing conditions of mesenchymal stem cells, as well as their cellular characterization, behavior and differentiation capacities. We also include research that focuses on identifying tissue sources of mesenchymal stem cells and their potential therapeutic applications in regenerative medicine and cellular therapies.
