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Muscle Cell News
Muscle Cell News is an online resource dedicated to the latest research into smooth, skeletal, and cardiac muscle cells.
Eliminating Elevated p53 Signaling Fails to Rescue Skeletal Muscle Defects or Extend Survival in Lamin A/C-Deficient Mice
[Cell Death Discovery] Using three laminopathy models, researchers found that increased p53 activity in Lmna-mutant muscle cells primarily resulted from mechanically induced damage to the myonuclei, and not from altered transcriptional regulation due to loss of lamin A/C expression.
Inhibitory Mechanisms of Docosahexaenoic Acid on Carbachol-, Angiotensin II-, and Bradykinin-Induced Contractions in Guinea Pig Gastric Fundus Smooth Muscle
[Scientific Reports] Investigators studied the inhibitory actions of docosahexaenoic acid on the contractions induced by carbachol, angiotensin II, and bradykinin in guinea pig gastric fundus smooth muscle, particularly focusing on the possible inhibition of store-operated Ca2+ channels .
Restoring Adiponectin via Rosiglitazone Ameliorates Tissue Wasting in Mice with Lung Cancer
[Acta Physiologica] Using the Kras/Lkb1 (KL) mouse model, the authors found that cancer-associated cachexia syndrome was associated with white adipose tissue dysfunction that directly affected skeletal muscle homeostasis.
The Drosophila Nesprin-1 Homolog MSP300 Is Required for Muscle Autophagy and Proteostasis Icon for the Forest of Biologists
[Journal of Cell Science] Researchers reported that the Drosophila Nesprin MSP300 had an additional function in autophagy within larval body wall muscles.
Urothelium-Derived Prostanoids Enhance Contractility of Urinary Bladder Smooth Muscle and Stimulate Bladder Afferent Nerve Activity in the Mouse
[American Journal of Physiology-Regulatory Integrative and Comparative Physiology] Scientists investigated whether select substances produced by the urothelium could directly modulate the contractility of the underlying urinary bladder smooth muscle.
SMYD2-Methylated PPARγ Facilitates Hypoxia-Induced Pulmonary Hypertension by Activating Mitophagy
[Circulation Research] Pulmonary hypertension (PH) animal models were generated by treating mice/rats with chronic hypoxia for four weeks. SMYD2-vTg mice or wild-type rats and mice treated with LLY-507 were used to investigate the function of suppressor of variegation, enhancer of zeste, trithorax and myeloid Nervy DEAF-1 domain-containing protein 2 (SMYD2) on PH development in vivo.
Deletion of TECRL Promotes Skeletal Muscle Repair by Up-Regulating EGR2
[Proceedings Of The National Academy Of Sciences Of The United States Of America] Scientists deciphered a mechanism that enabled the proliferation and differentiation of satellite cells through the downregulation of trans-2,3-enoyl-CoA reductase like (TECRL) during muscle regeneration.
Allele-Specific Suppression of Variant MHC with High-Precision RNA Nuclease CRISPR-Cas13d Prevents Hypertrophic Cardiomyopathy
[Circulation] On the basis of Cas13d homology structure, researchers rationally designed a series of Cas13d variants and obtained a high-precision Cas13d variant that specifically cleaved the MYH7 variant RNAs containing 1 allelic single nucleotide variant.
Vascular Smooth Muscle-Specific LRRC8A Knockout Ameliorates Angiotensin II-Induced Cerebrovascular Remodeling by Inhibiting the WNK1/FOXO3a/MMP Signaling Pathway
[Acta Pharmacologica Sinica] Researchers used vascular smooth muscle-specific leucine-rich repeat-containing family 8 A (LRRC8A) knockout mice and an angiotensin II-induced hypertension model.
Inhibition of TBL1 Cleavage Alleviates Doxorubicin-Induced Cardiomyocytes Death by Regulating the Wnt/β-Catenin Signal Pathway
[Cardiovascular Research] Researchers observed a reduction in transducin beta-like protein 1 (TBL1) protein expression levels as well as cleavage events in the transplanted cardiac tissues of patients diagnosed with dilated cardiomyopathy and doxorubicin-induced cardiotoxicity.
Skeletal Muscle Hypertrophy Rewires Glucose Metabolism: An Experimental Investigation and Systematic Review
[Journal Of Cachexia Sarcopenia And Muscle] The authors used mass spectrometry in hypertrophying C2C12 myotubes in vitro and plantaris mouse muscle in vivo and assessed metabolomic changes and the incorporation of the [U-13C6]glucose tracer.
Adducin Regulates Sarcomere Disassembly During Cardiomyocyte Mitosis
[Circulation] Researchers used a proteomics screen to identify adducin, an actin capping protein previously not studied in cardiomyocytes, as a regulator of sarcomere disassembly.
Every day, our editorial team sifts through the most recent scientific literature to help keep researchers and medical professionals current. Muscle Cell News covers the three types of muscle cells: cardiac, skeletal, and smooth muscle. We cover a broad range of topics, including cell culturing, muscle regeneration, and musculoskeletal disorders.
