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Muscle Cell News is an online resource dedicated to the latest research into smooth, skeletal, and cardiac muscle cells.
Spatio-Temporal Calcium Signaling Patterns Underlying Opposing Effects of Histamine and TAS2R agonists in Airway Smooth Muscle
[American Journal of Physiology-Lung Cellular and Molecular Physiology] The authors investigated the spatio-temporal dynamics of Ca2+ signaling in airway smooth muscle (ASM) cells using single-cell microscopy and deep learning-based segmentation, integrating the results into a comprehensive model of ASM ion channel dynamics to compare the effects of histamine, CQ, and flufenamic acid.
Pig Models Reveal the Interplay between Fatty Acids and Cytokines in Skeletal Muscle
[Scientific Reports] Scientists investigated the gene co-expression profiles in the skeletal muscle of pigs fed diets supplemented with 3.0% soybean, canola, or fish oils, correlating these profiles with cytokine abundance and identifying hub genes associated with immune-related pathways using a systems biology approach.
SREBP1 Deficiency Aggravates Vascular Calcification via iASPP-Triggered Ferroptosis of Vascular Smooth Muscle Cells
[Cardiovascular Diabetology] Bioinformatics analysis was employed to mine the dataset and screen sterol regulatory element-binding protein 1 (SREBP1) related to ferroptosis and vascular calcification. Quantitative real-time polymerase chain reaction, western blotting, immunofluorescence, and immunohistochemistry were used to analyze gene expression.
Muscle Stem Cells in Duchenne Muscular Dystrophy Exhibit Molecular Impairments and Altered Cell Fate Trajectories Impacting Regenerative Capacity
[Cell Death & Disease] Scientists used single-cell RNA-sequencing to determine how dystrophin deficiency impacts the satellite cell transcriptome and cellular composition by comparing satellite cells from mdx and the more severe D2-mdx Duchenne muscular dystrophy mouse models.
Cardiomyocyte-Localized CCDC25 Senses NET DNA to Promote Doxorubicin Cardiotoxicity by Activating Autophagic Flux
[Nature Cancer] The authors observed a substantial increase in circulating neutrophil extracellular trap (NET) DNA in individuals with lymphoma experiencing cardiotoxicity after anthracycline-containing treatment.
mTOR Inhibition Triggers Mitochondrial Fragmentation in Cardiomyocytes through Proteosome-Dependent Prohibitin Degradation and OPA-1 Cleavage
[Cell Communication and Signaling] Investigators studied the role of mTOR in OPA-1 cleavage and its consequent effects on mitochondrial dynamics and energetics in cardiomyocytes.
NEXN Regulates Vascular Smooth Muscle Cells Phenotypic Switching and Neointimal Hyperplasia
[JCI Insight] Using integrative transcriptomics analysis and smooth muscle specific lineage tracing mice, scientists demonstrated NEXN is highly expressed in vascular smooth muscle cells (VSMCs), and the expression of NEXN is significantly reduced during the phenotypic transformation of VSMCs and intimal hyperplasia induced by vascular injury.
Inhibition of Serotonin-Htr2b Signaling in Skeletal Muscle Mitigates Obesity-Induced Insulin Resistance
[Experimental & Molecular Medicine] Researchers identified the 5-HT receptor 2b (Htr2b) as a critical regulator of insulin sensitivity and energy metabolism in the skeletal muscle.
GL261 Glioblastoma Induces Delayed Body Weight Gain and Stunted Skeletal Muscle Growth in Young Mice
[American Journal of Physiology-Regulatory Integrative and Comparative Physiology] Scientists showed that pediatric brain tumors stunt muscle development in young mice. GL261 glioblastoma cells cause myotube atrophy, reduced carcass, heart, and fat mass, and impeded skeletal muscle growth.
Interleukin‐1 Signaling on Vascular Smooth Muscle Cells Accelerates Atherosclerosis in a Murine Model of Kawasaki Disease
[Journal of The American Heart Association] Researchers investigated the contribution of interleukin‐1 signaling on vascular smooth muscle cells in a murine model of Kawasaki Disease.
Arginase 1 Drives Mitochondrial Cristae Remodeling and PANoptosis in Ischemia/Hypoxia-Induced Vascular Dysfunction
[Signal Transduction and Targeted Therapy] Using rat models of ischemia and hypoxic vascular smooth muscle cells, the authors combined transmission electron microscopy, super-resolution microscopy, and metabolic analysis to analyze the structure and function change of mitochondrial cristae.
Afadin Promotes Vascular Smooth Muscle Cell Contraction by Interacting with Phospholipase C to Enhance Ca2+ Signaling for Blood Pressure Regulation
[Arteriosclerosis Thrombosis and Vascular Biology] Vascular smooth muscle cells (VSMCs) were isolated from newly generated VSMC-specific afadin conditional knockout mice. A small peptide designed in silico to inhibit the afadin-phospholipase C β association was administered to the mouse VSMCs and aortic media using adeno-associated virus.
Every day, our editorial team sifts through the most recent scientific literature to help keep researchers and medical professionals current. Muscle Cell News covers the three types of muscle cells: cardiac, skeletal, and smooth muscle. We cover a broad range of topics, including cell culturing, muscle regeneration, and musculoskeletal disorders.
