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Muscle Cell News
Muscle Cell News is an online resource dedicated to the latest research into smooth, skeletal, and cardiac muscle cells.
Adducin Regulates Sarcomere Disassembly During Cardiomyocyte Mitosis
[Circulation] Researchers used a proteomics screen to identify adducin, an actin capping protein previously not studied in cardiomyocytes, as a regulator of sarcomere disassembly.
Inhibition of Hmbox1 Promotes Cardiomyocyte Survival and Glucose Metabolism Through Gck Activation in Ischemia/Reperfusion Injury
[Circulation] Scientists studied the function of homeobox-containing 1 (Hmbox1) in exercise-induced physiological cardiac growth in mice after four weeks of swimming exercise. Hmbox1 expression was then evaluated in human heart samples from deceased patients with myocardial infarction and in the animal cardiac ischemia/reperfusion injury model.
Use of iPSC-Derived Smooth Muscle Cells to Model Physiology and Pathology
[Arteriosclerosis Thrombosis And Vascular Biology] Challenges both specific, e.g. the lack of specific markers to thoroughly validate human induced pluripotent stem cell-smooth muscle cells (hiPSC-SMC), and general, e.g. a lack of transparency and consensus around methodology in the field, remain. Scientists highlight the recent successes and remaining challenges of the hiPSC-SMC model.
Heart Disease Research in Doberman Patient Replaces Animal Experiments
[Utrecht University] A team of researchers from Utrecht University and UMC Utrecht has received a grant of 936,587 euros from the ZonMw Open Competition for research into a serious heart condition that affects both humans and dogs, especially Dobermanns.
High Fat Diet Ameliorates Mitochondrial Cardiomyopathy in CHCHD10 Mutant Mice
[EMBO Molecular Medicine] Heterozygous S55L mice were subjected to chronic high-fat diet to decrease insulin sensitivity and glucose uptake and enhance fatty acid utilization in the heart.
Mitochondria Regulate Proliferation in Adult Cardiac Myocytes
[Journal Of Clinical Investigation] Researchers tested whether forced reversal of adult cardiomyocytes back to a fetal glycolytic phenotype would restore proliferative capacity. They deleted Uqcrfs1 in hearts of adult mice.
Sfrp5 Overexpression Reverses oxLDL-Induced Lipid Accumulation in HVSMCs
[Bioscience, Biotechnology, and Biochemistry] Researchers found that Sfrp5 expression in oxLDL-treated human vascular smooth muscle cells (HVSMCs) was downregulated. Sfrp5 overexpression inhibited the viability of HVSMCs induced by oxLDL.
IL1β-NFκβ-Myocardin Signaling Axis Governs Trophoblast-Directed Plasticity of Vascular Smooth Muscle Cells
[FASEB Journal] Analysis of genetic markers on E13.5, E16.5, and E19.5 in the rat metrial gland, the entry point of uterine arteries, revealed that trophoblast invasion was associated with downregulation of MYOCARDIN, α-smooth muscle actin, and calponin1, and concomitant upregulation of Smemb in vascular smooth muscle cells.
Generation of Allogenic and Xenogeneic Functional Muscle Stem Cells for Intramuscular Transplantation
[Journal Of Clinical Investigation] The authors investigated whether satellite cells could be derived in allogeneic or xenogeneic animal hosts.
Myospreader Improves Gene Editing in Skeletal Muscle by Myonuclear Propagation
[Proceedings Of The National Academy Of Sciences Of The United States Of America] By screening nuclear localization signals and nuclear export signals, researchers identified “Myospreader,” a combination of short peptide sequences that promoted myonuclear propagation.
Brain-Muscle Communication Prevents Muscle Aging by Maintaining Daily Physiology
[Science] Scientists examined the interactions and importance of intratissue clock networks in muscle tissue maintenance. In arrhythmic mice showing premature aging, they created a basic clock module involving a central and a peripheral clock.
PPMD Awards $250,000 to Support Clinical Research Network for Duchenne Babies Identified by Newborn Screening
[Parent Project Muscular Dystrophy (PPMD)] PPMD announced a $250,000 award to Bo Hoon Lee, MD, from the University of Rochester to support the development of a clinical research network for Duchenne babies identified through newborn screening efforts in New York State.
Every day, our editorial team sifts through the most recent scientific literature to help keep researchers and medical professionals current. Muscle Cell News covers the three types of muscle cells: cardiac, skeletal, and smooth muscle. We cover a broad range of topics, including cell culturing, muscle regeneration, and musculoskeletal disorders.
