Neural Cell News

Neural Cell News is an online resource covering the latest research in neuroscience, neural stem cells, and neurological conditions.

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Human Brain Organoids Record the Passage of Time over Multiple Years

September 2, 2026

[Nature] Investigators developed human brain organoids for 5 years in culture, optimizing growth conditions to extend excitatory neuron viability beyond previous limits.

Aberrant Excitatory Neuronal ERBB4 Promotes Alzheimer’S Disease Pathology

September 2, 2026

[Nature] Scientists demonstrated that, during Alzheimer’s disease progression in mice, astrocytes, and microglia increase phagocytic elimination of excitatory synapses while reducing elimination of inhibitory synapses.

Targeting Tumor-Neuron Synapses with Intracavitary RNA Delivery Prevents Glioblastoma Recurrence

September 2, 2026

[Nature Biomedical Engineering] Researchers defined the spatial and molecular determinants of malignant synapses by analysing intact human glioblastoma specimens, revealing enrichment of synapse-like structures and synapse-associated gene programmes at the tumor–brain interface.

Cholesterol Dysregulation in APOE4 Astrocytes Promotes α-Synuclein Pathology in Mibrains

September 2, 2026

[Cell Stem Cell] The authors developed an iPSC-based 3D model that integrates neurons, glia, myelin, and cerebrovascular cells into a human brain-like tissue (“miBrain”). Single-nucleus RNA sequencing of miBrains confirmed the presence of diverse cell populations and revealed transcriptional responses to α-synuclein pathology.

A Bifunctional Optical Reporter for Tracking Estrogen Response Dynamics in Neurons

September 2, 2026

[Neuron] Scientists developed the fluorescent bifunctional reporter neuro-seeER, “see estrogen response”, that can be used to track changes in estrogen dynamics in vitro and in vivo, including longitudinally in behaving animals.

An Axon-Intrinsic Loop Restricts Nerve Regeneration through Axonal Protein Synthesis

September 2, 2026

[Science Advances] Researchers showed that local synthesis of Regenerating Family Member 3α, REG3A, in injured nerves activates translation of axonal KH-type splicing regulatory factor, Khsrp, mRNA in regenerating axons to slow peripheral nervous system nerve regeneration.

CUDC-907 Inhibits Glioblastoma and Enhances Glioblastoma Sensitivity to Temozolomide by Inhibiting DNA Damage Repair

September 2, 2026

[Genes & Diseases] The authors investigated the effects of CUDC-907 on glioblastoma using cellular, organoid, and animal models to assess its inhibitory potential and toxicity.

Nerve Growth Factor Receptor (NGFR): A Key Player in Glioblastoma Progression

September 2, 2026

[Biochimica Et Biophysica Acta-Reviews On Cancer] Investigators synthesize available literature on the role of the NGFR, particularly the p75 neurotrophin receptor, in glioblastoma progression.

Yale School of Medicine Awarded a Nearly $25 Million Grant to Map the Developing Brain and Advance Autism Research

September 2, 2026

[Yale School of Medicine] Yale School of Medicine received a grant of nearly $25 million from the Aligning Research to Impact Autism to map human brain development and investigate how and when autism diverges from typical development.

New KWF Funding Boosts 8 CCA Cancer Research Projects

August 21, 2026

[Amsterdam UMC] KWF announced 34 research projects that will receive funding in its latest round — including 8 projects involving Cancer Center Amsterdam (CCA) researchers.

Procognitive Restoration of PV Neuron Plasticity in Neurodevelopmental Disorders

August 18, 2026

[Nature] Investigators showed that restoring plasticity in parvalbumin neurons can improve cognition and suppress seizures in a neurodevelopmental disorder model, suggesting that some developmental circuit deficits may be reversible in adulthood.

PLCG2 Downregulation Impairs Synaptic Function and Increases Alzheimer’s Disease Hallmarks in Neuronal Cultures

August 18, 2026

[Nature Genetics] Scientists developed a high-content screening to investigate how Alzheimer’s disease genetic risk factors may affect synaptic mechanisms in rat primary neuronal cultures.

Neural Cell News helps scientists keep pace with the latest research, reviews, and industry developments in neuroscience. Specific research topics include neural development and neuroregeneration, neural signaling related to cellular responses and behavior, and synaptic plasticity. Research into the diagnosis, progression, cellular characteristics, and treatment of brain diseases such as Parkinson’s, Multiple Sclerosis, Alzheimer’s, Amyotrophic Lateral Sclerosis and various brain cancers, as well as brain damage resulting from infection, trauma, stroke, seizures, and tumors, is also covered.