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Neural Cell News
Neural Cell News is an online resource covering the latest research in neuroscience, neural stem cells, and neurological conditions.
Neurons and Astrocytes Have Distinct Organelle Signatures and Responses to Stress
[Cell Reports] Scientists used multispectral imaging to simultaneously visualize six organelles—endoplasmic reticulum, lysosomes, mitochondria, peroxisomes, Golgi, and lipid droplets—in live primary rodent neurons and astrocytes.
Synaptic Imbalance and Increased Inhibition Impair Motor Function in SMA
[Science Advances] Scientists used functional, morphological, and viral-mediated approaches to uncover the pathogenic contribution of unbalanced excitation-inhibition in a mouse model of spinal muscular atrophy (SMA).
Astrocytic Mettl14 Depletion Enhances Cognitive Function by Attenuating Astrogliosis via the DUSP1/MAPK Pathway in APP/PS1 Mice: Targeting Neuroinflammation in Alzheimer’s Disease
[Molecular Psychiatry] Investigators used a Mettl14 conditional knockout APP/PS1 mouse model to investigate the effects of modulating astrocytic N6-methyladenosine levels on Alzheimer's disease progression.
Microglia-to-Neuron Signaling Links APOE4 and Inflammation to Enhanced Neuronal Lipid Metabolism and Network Activity
[Proceedings of The National Academy of Sciences of The United States of America] The authors used a reductionist model of human iPSC-derived microglial and neuronal monocultures to dissect how the APOE genotype in each cell type independently contributes to microglial regulation of neuronal activity during inflammation.
Neurons Sequester the Cholesterol-Inhibiting TFEB in Oligodendrocyte Cytoplasm to Safeguard Myelination and Neural Function
[Cell Reports] Researchers identified transcription factor EB (TFEB) as a molecular link that connects extrinsic neuronal cues to intrinsic oligodendrocyte transcriptional programs, regulating central nervous system myelination.
The KAP1 Chromatin Regulator and Paupar Long Non-Coding RNA Control Subventricular Zone Neural Stem Cell Maintenance and Neurogenesis
[Stem Cell Reports] In the last stages of olfactory bulb neurogenesis, Paupar and KAP1 affect rates of neurogenesis. Scientists investigated upstream functions with inducible knockout and in vivo knockdown electroporation and molecular analysis.
Neddylation Regulates the Development and Function of Glutamatergic Neurons
[Communications Biology] The authors generated a conditional Nedd8 knock-out mouse line and examined the consequences of Nedd8-deletion in cultured post-mitotic glutamatergic neurons.
Mechanisms and Treatment of Cancer Therapy-Induced Peripheral and Central Neurotoxicity
[Nature Reviews Cancer] Neurotoxicity is a common and potentially severe adverse effect from conventional and novel cancer therapy. The mechanisms that underlie clinical symptoms of central and peripheral nervous system injury remain incompletely understood.
Sylvain Baillet Inducted into the Royal Society of Canada
[McGill University] Dr. Sylvain Baillet, a global leader in brain imaging and systems neuroscience, has been inducted into the Royal Society of Canada, one of the nation’s highest academic honors.
Single-Cell Glycome and Transcriptome Profiling Uncovers the Glycan Signature of Each Cell Subpopulation of Human iPSC-Derived Neurons
[Stem Cell Reports] Investigators applied scGR-seq to examine heterogeneous populations of human iPSC-derived neurons. They identified four subpopulations: mature neurons, immature neurons, undifferentiated neural progenitor cells, and mesenchymal cells.
Cooperative Actions of Interneuron Families Support the Hippocampal Spatial Code
[Science] The authors revealed a fundamental role for the cooperative function of interneuron families in the emergence of the hippocampal cognitive map.
PICALM Alzheimer’s Risk Allele Causes Aberrant Lipid Droplets in Microglia
[Nature] Scientists systematically identified putative causal late-onset Alzheimer’s disease (LOAD)-risk variants in hiPSC-derived neurons, astrocytes, and microglia, and linked a PICALM LOAD-risk allele to a microglial-specific role of PICALM in lipid droplet accumulation.
Neural Cell News helps scientists keep pace with the latest research, reviews, and industry developments in neuroscience. Specific research topics include neural development and neuroregeneration, neural signaling related to cellular responses and behavior, and synaptic plasticity. Research into the diagnosis, progression, cellular characteristics, and treatment of brain diseases such as Parkinson’s, Multiple Sclerosis, Alzheimer’s, Amyotrophic Lateral Sclerosis and various brain cancers, as well as brain damage resulting from infection, trauma, stroke, seizures, and tumors, is also covered.
