Neural Cell News

Neural Cell News is an online resource covering the latest research in neuroscience, neural stem cells, and neurological conditions.

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New WAM Grants Support Research on Gut-Brain Interactions, Menopause, and Sarcopenia

May 13, 2026

[Cleveland Clinic] The Women’s Alzheimer’s Movement (WAM) at Cleveland Clinic awarded grants for three of the most promising research projects in the field of gut-brain interactions, menopause, and sarcopenia.

Astroglial Disinhibition of Cortical Circuits Disrupts Cognition via Kynurenic Acid in Mice

May 13, 2026

[Nature Communications] Researchers identified astrocyte-derived kynurenic acid (KYNA), a neuroactive metabolite known to modulate multiple neurotransmitter receptor systems, including the N-methyl-D-aspartate receptor (NMDA), as a mediator of cognitive dysfunction in the context of aberrant astrocyte activity.

α/Sulfonyl-γ-AApeptide Foldamers Mitigate Alzheimer’S Disease Pathology by Stabilizing Transient Helical Domains in aβ

May 13, 2026

[Nature Communications] Investigators reported a synthetic peptidomimetic foldamer, M4, as a potent modulator of amyloid-β (Aβ) 42 aggregation. Biophysical analyses demonstrate that M4 binds Aβ with high affinity, inhibits oligomer formation, and remodels pre-existing aggregates.

Flash Assembloids: A Rapid Biofabrication of a Platform for Modeling Early Glioblastoma Invasion at the Glioblastoma-Brain Organoid Interfaces

May 13, 2026

[Advanced Healthcare Materials] Scientists presented a bioengineered assembloid system that integrates glioblastoma cells encapsulated in self-degradable 5% oxidized alginate microgel with dorsal forebrain organoids to recapitulate early tumor-host interactions during glioblastoma invasion toward the brain.

Molecular Subtypes and the (In Vitro) Response of Glioblastoma to Temozolomide

May 13, 2026

[BJC reports] Researchers addressed the therapeutic relevance of glioblastoma (GBM)’s molecular characterization, focusing on whether a proneural-vs-mesenchymal classification may describe GBM heterogeneity, correlate to stemness and CD44, and have a prognostic value in terms of temozolomide resistance.

Discovery of a Pyrazolopyridine Alkaloid That Mitigates Neuronal ER Stress and Age-Related Decline

May 13, 2026

[Communications Biology] Investigators developed an integrative discovery strategy to identify natural compounds that mitigate endoplasmic reticulum (ER)-stress-associated phenotypes across cellular and organismal models.

Modeling Friedreich’s Ataxia with Bergmann Glia-Enriched Human Cerebellar Organoids

May 13, 2026

[Communications Biology] Scientists reported the generation of hiPSC-derived cerebellar organoids that are characterized by induction of rhombomere 1 cellular identity and followed by derivation of typical neuronal and glial cell types of the cerebellum.

Minibeam Radiation Therapy Does Not Induce Canonical Immunogenic Cell Death or cGAS-STING Activation in Glioblastoma and Astrocyte Monocultures

May 13, 2026

[Scientific Reports] Investigators hypothesised that immunogenic cell death or cGAS-STING pathway activation could be involved. They evaluated cell death, damage-associated molecular patterns, RT1a exposure, and cGAS-STING activation 24 h after irradiation.

The Promising Role of Cathepsins As Biomarkers and Therapeutic Targets in Glioblastoma

May 13, 2026

[Discover Oncology] The authors provide a comprehensive overview of current knowledge on the role of cathepsins in glioblastoma biology.

Researchers Urge Providers to Consider Regimen for Patients Whose Tumors Harbor Specific Mutations

May 4, 2026

[UC News] Researchers at the University of Cincinnati (UC) Gardner Neuroscience Institute’s Brain Tumor Center have been confirmed as the first in the world to achieve complete remission of a rare pituitary cancer using a novel immunotherapy treatment.

Curing the Brain: In Search for New Astrocyte-Specific Therapies

April 28, 2026

[Experimental & Molecular Medicine] Scientists focus on astroglia; they briefly introduce these cells from an evolutionary and functional perspective, they present the general pathophysiology of astroglia, and finally they discuss how to target astroglial cells in cognitive brain disorders.

Modeling Glioblastoma Relapse In Vitro: A Critical Journey from 2D Models to Organ-on-Chip Alternatives

April 28, 2026

[NPJ Precision Oncology] The authors explore the spectrum of in vitro models that have been established to study human GBM relapse, including 2D cultures, 3D spheroids/organoids, microfluidic, and organ-on-a-chip systems.

Neural Cell News helps scientists keep pace with the latest research, reviews, and industry developments in neuroscience. Specific research topics include neural development and neuroregeneration, neural signaling related to cellular responses and behavior, and synaptic plasticity. Research into the diagnosis, progression, cellular characteristics, and treatment of brain diseases such as Parkinson’s, Multiple Sclerosis, Alzheimer’s, Amyotrophic Lateral Sclerosis and various brain cancers, as well as brain damage resulting from infection, trauma, stroke, seizures, and tumors, is also covered.