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Neural Cell News
Neural Cell News is an online resource covering the latest research in neuroscience, neural stem cells, and neurological conditions.
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Engineered GM1 Intersects Between Mitochondrial and Synaptic Pathways to Ameliorate ALS Pathology
[Advanced Science] Researchers conducted proteomic analyses of human iPSC-derived motor neurons carrying C9ORF72 mutations, alongside spinal ventral horns from mice with pathogenic C9orf72-mutations.
Distinct Endocannabinoids Specifically Signal to Astrocytes or Neurons in the Adult Mouse Hippocampus
[Nature Neuroscience] Investigators showed that 2-arachidonoylglycerol selectively signals to neurons, eliciting the depression, which is mediated exclusively by neuronal mechanisms.
TGFβ Signaling Mediates Microglial Resilience to Spatiotemporally Restricted Myelin Degeneration
[Nature Neuroscience] By examining spinal cord white matter tracts in mice, the authors determined that myelin degeneration was particularly prominent in the dorsal column during normal aging.
NLRP3 Facilitates α-Synuclein-Induced Dopaminergic Neuronal Senescence in a Mouse Model of Parkinson’s Disease through SATB1/DNA Damage/P21 Signaling Pathway
[Acta Pharmacologica Sinica] Scientists identified the cell type susceptible to α-synuclein-induced cellular senescence in the substantia nigra and investigated the specific role of microglia with a particular focus on the NLRP3 inflammasome.
Atypical Cell Cycle Regulation over Neural Stem Cell Expansion
[Stem Cell Reports] Using a conditional mouse model, we demonstrate that driving the expression of Spy1, in the Nestin-enriched NSC population of the brain, increases stemness characteristics, decreases differentiation, and increases susceptibility to oncogenic transformation.
DMTF1 Up-Regulation Rescues Proliferation Defect of Telomere Dysfunctional Neural Stem Cells via the SWI/SNF-E2F Axis
[Science Advances] Investigators found that DMTF1, a transcription factor that regulates the Arf/p53 axis in cancer, is down-regulated in the NSCs of a premature aging model driven by telomerase deficiency.
The LRRK2 P1446L Mutation Triggers Dopaminergic Neurodegeneration via DAPK1-Mediated Microglial Neuroinflammation and Neuronal Apoptosis
[NPJ Parkinson'S Disease] Researchers designed LRRK2-P1446L mutant mice and demonstrated that the novel LRRK2-P1446L mutation drives neurodegeneration through death-associated protein kinase 1 (DAPK1) dysregulation.
CRISPR Screens in Human Neural Organoids and Assembloids
[Nature Protocols] Scientists presented a protocol that combines pooled CRISPR–Cas9 screening with neural organoid and assembloid models and illustrate how it can be applied to map hundreds of disease genes onto cellular pathways and specific aspects of human neural development.
Oxidized MIF Is an Alzheimer’s Disease Drug Target Relaying External Risk Factors to Tau Pathology
[Cell Reports Medicine] Researchers presented the discovery of a host protein-targeted antiviral drug highly active against HSV-1 in human brain organoids and human neuronal cell lines with a clear structure-activity relationship.
NAT10-Mediated N4-Acetylcytidine (Ac4c) Modification of PIK3R2 mRNA Promotes Malignant Progression of Glioblastoma
[Cell Death & Disease] Investigators found that NAT10 is highly expressed in glioblastoma and is positively correlated with malignant pathological features and poor prognosis in patients.
Immuno-Regulation of Brain Region-Specific Organoids Containing Isogenic Microglia-Like Cells
[Advanced Healthcare Materials] iPSC-derived microglia-like cells are co-cultured with isogenic forebrain cortical organoids, which were stimulated with extracellular vesicles of brain organoids differentiated from Alzheimer's disease patient-derived iPSCs.
Identification of Raptor and GLI1 As USP37 Substrates Highlight Its Context-Specific Function in Medulloblastoma Cells
[Oncogene] Scientists identifed Raptor and GLI1 as novel USP37 targets in sonic hedgehog-medulloblastoma and also suggest that ubiquitin specific protease 37 (USP37) may have context-specific oncogenic roles in addition to its previously described tumor suppressive function in these tumors.
Neural Cell News helps scientists keep pace with the latest research, reviews, and industry developments in neuroscience. Specific research topics include neural development and neuroregeneration, neural signaling related to cellular responses and behavior, and synaptic plasticity. Research into the diagnosis, progression, cellular characteristics, and treatment of brain diseases such as Parkinson’s, Multiple Sclerosis, Alzheimer’s, Amyotrophic Lateral Sclerosis and various brain cancers, as well as brain damage resulting from infection, trauma, stroke, seizures, and tumors, is also covered.
