Neural Cell News

Neural Cell News is an online resource covering the latest research in neuroscience, neural stem cells, and neurological conditions.

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Oligomerix Awarded $1.9 M NIH Phase II SBIR Fast-Track Grant to Conduct Safety Studies Required for Clinical Studies of OLX-07010 in Alzheimer’s Patients

June 24, 2026

[Oligomerix, Inc. (Business Wire)] Oligomerix, Inc. announced an National Institutes of Health (NIH) Fast Track Phase II award of $1.9 million from the National Institute on Aging of the NIH.

Confined Migration Induces Non-Lethal DNA Damage in Developing Neurons

June 24, 2026

[Nature] Researchers found that neurons routinely sustain DNA breaks during cortex formation, but a rapid repair system corrects the damage before harm occurs.

EGR1 Mediates Neuronal Damage via Suppressing HIF1A-Induced Mitophagy Following Traumatic Brain Injury

June 24, 2026

[Autophagy] Using integrated transcriptomic and epigenomic analyses, scientists identified EGR1 as a critical regulator of traumatic brain injury pathology, with its expression acutely upregulated in neurons post-injury.

The EMB/ATG7-Mediated Autophagic Process Regulates Neurite Outgrowth and Promotes Enteric Neuronal Development

June 24, 2026

[Proceedings of the National Academy of Sciences of the United States of America] Investigators identified embigin (EMB) as a critical regulator of enteric neuronal maturation. In EMB mutant patients, the expression of EMB is reduced in the enteric neurons of the hypoganglionosis-affected colon.

Hypoxia-Induced circSPECC1 Drives Temozolomide Resistance in Glioblastoma via IGF2BP2-Mediated PGK1 mRNA Stabilization

June 24, 2026

[Cell Death & Disease] By integrating multiomics profiling with functional assays in patient-derived glioblastoma cells, orthotopic xenografts, and clinical specimens, scientists aimed to elucidate the role of hypoxia-induced hsa_circ_0000745 (circSPECC1) in mediating temozolomide resistance.

Sex-Linked Helicases DDX3X and DDX3Y Regulate G-Quadruplex-Associated Stress in Neurons

June 24, 2026

[Cell Death & Disease] The authors investigated how neurons respond to genotoxic stress induced by quarfloxin (CX-3543), a small molecule that stabilizes G-quadruplexes.They found that quarfloxin treatment induced DNA damage in neurons, with double-strand breaks enriched in the nucleolus.

Signaling of glycoRNAs to Siglec-11 Protects Neurons by Suppressing NF-κB

June 24, 2026

[Cell Chemical Biology] Through neuron-like and glia-like co-culture models, researchers identified a neuron’s protective mechanism mediated by membrane-associated glycoRNAs.

Growth Differentiation Factor 11 (GDF11) Signaling in Neural Stem Cell Regulation: Molecular and Cellular Insights

June 24, 2026

[Reviews in the Neurosciences] Scientists address the most recent molecular mechanisms of GDF11 signaling in the regulation of neural stem cell, linking TGF-β signaling, neurogenesis, and brain aging.

Acquired Genetic and Cell-State Changes in IDH-Mutant Glioma Progression

June 10, 2026

[Nature] Researchers showed that malignant cell states transcriptionally resemble stages of normal glial–neuronal lineage development or a reactive mesenchymal-like state, mirroring states previously described in isocitrate dehydrogenase (IDH) wild-type glioblastoma.

Epigenetic Control of Microglial Mitochondrial Immunity by KAT7 Drives Alzheimer’S Disease Pathogenesis

June 10, 2026

[Neuron] Investigators identified the histone acetyltransferase KAT7 as a central epigenetic regulator that links chromatin remodeling to mitochondrial immune activation.

IQGAP3 Bridges Matrix Stiffness with Glioma Stem Cell Maintenance and Radioresistance by Stabilizing SOX2

June 10, 2026

[Nature Communications] Differential gene expression revealed that stiff matrices induce expression of IQ Motif Containing GTPase Activating Protein 3 (IQGAP3) through YAP1 and TEAD transcription factors in GBM stem cells.

Microglial CD31 Suppresses aβ Clearance and Promotes Alzheimer Pathology in 5×FAD Mice

June 10, 2026

[Nature Communications] The authors showed that CD31, a recognized endothelial marker, is predominantly expressed in microglia but not in neurons or astrocytes, and it is significantly elevated in the brains of Alzheimer’s disease patients and mouse models.

Neural Cell News helps scientists keep pace with the latest research, reviews, and industry developments in neuroscience. Specific research topics include neural development and neuroregeneration, neural signaling related to cellular responses and behavior, and synaptic plasticity. Research into the diagnosis, progression, cellular characteristics, and treatment of brain diseases such as Parkinson’s, Multiple Sclerosis, Alzheimer’s, Amyotrophic Lateral Sclerosis and various brain cancers, as well as brain damage resulting from infection, trauma, stroke, seizures, and tumors, is also covered.