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Neural Cell News is an online resource covering the latest research in neuroscience, neural stem cells, and neurological conditions.
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An Oncostatin M Receptor and Chloride Intracellular Channel 1 Crosstalk Drives Key Oncogenic Pathways in Glioblastoma
[Signal Transduction and Targeted Therapy] Researchers uncovered a bidirectional crosstalk between Oncostatin M receptor (OSMR) and tmCLIC1 in glioblastoma, essential for fueling its malignant growth.
Ferroptosis Susceptibility in Hippocampal Neural Precursor Cells Influences Neurogenesis and Memory across Aging
[Cell Stem Cell] Scientists tested whether ferroptosis-related vulnerability contributes to the regulation of hippocampal neural precursor cells and their progeny.
Light- and Chemical-Induced Ciliary Signaling Governs Dorsal/Ventral Regionalization of Human Telencephalic Organoids
[Nature Communications] Using a human telencephalic organoid model, investigators performed comprehensive proteomic profiling of neural stem/progenitor cell cilia and found enrichment in GTPase signaling.
Mapping Neuro-Vascular Unit Communications Reveals Distinct Angiogenic Programs across Developing Mouse Brain Regions
[Nature Communications] Researchers combined spatial transcriptomics with region-resolved endothelial single-cell RNA sequencing in the postnatal mouse brain to map cortical and thalamic neurovascular unit communication dynamics.
TRP/P53 Protects Adult Hippocampal Neural Stem Cells from Psychological Stress by Preventing Autophagic Cell Death
[Autophagy] Scientists demonstrated that, contrary to its well-established pro-apoptotic role, TRP53 acts as a survival factor that protects ahNSCs from stress-induced autophagic cell death.
Novel IDH1-Targeting Fluorescent Probe Enables Intraoperative Visualization and Resection of Glioblastoma
[Analytical Chemistry] Investigators developed a novel fluorescent probe, QM-SO3H, that targets the wild-type IDH1 enzyme to enable intraoperative navigation for glioblastoma.
TIM-3 in AML: A Janus-Faced Orchestrator of Immune Exhaustion and Leukemic Self-Renewal
[Cancer Cell International] The authors synthesize emerging evidence that T cell immunoglobulin and mucin-domain containing-3 operates dually: on one edge, it acts as an important contributor to immune exhaustion, suppressing T cell, natural killer cell, and dendritic cell function within the AML niche.
Brain Cancer Canada Invests $50,000 in Promising Immunotherapy Breakthrough Targeting One of the Most Aggressive Brain Tumours
[Brain Cancer Canada (Globe Newswire)] Brain Cancer Canada awards $50,000 to an exciting research project led by Dr Ian Lorimer and his team at Ottawa Hospital Research Institute. The project titled “Improving glioblastoma immunotherapy by selectively blocking macrophage activity” explores a new way of possibly treating glioblastoma and might soon pave the way for a clinical trial.
15 Million for Research on Cell Therapy for Parkinson’s Disease
[Karolinska Institutet] Karolinska Institutet has received a grant of DKK 10 million (approximately SEK 15 million) from the Novo Nordisk Foundation for research on cell therapy for Parkinson’s disease. The project is led by Johan Ericson, professor at the Department of Cell and Molecular Biology.
Using iPSC Models to Examine Neuron-Glia Interactions in Neurodegenerative Diseases
[Bioscience Reports] The authors discuss recent insights into the mechanisms contributing to neurodegenerative disease that have been gained specifically from modelling neuron–glia interactions in human iPSCs.
Matthew Larson Foundation Grant Helps Cancer Center Researcher Find New Ways to Treat Deadly Pediatric Brain Tumors
[University of Colorado Anschutz Cancer Center] Dr. Siddhartha Mitra recently received a three-year grant to develop chimeric antigen receptor (CAR) macrophages therapies to treat diffuse midline gliomas, a particularly deadly type of pediatric brain cancer.
New WAM Grants Support Research on Gut-Brain Interactions, Menopause, and Sarcopenia
[Cleveland Clinic] The Women’s Alzheimer’s Movement (WAM) at Cleveland Clinic awarded grants for three of the most promising research projects in the field of gut-brain interactions, menopause, and sarcopenia.
Neural Cell News helps scientists keep pace with the latest research, reviews, and industry developments in neuroscience. Specific research topics include neural development and neuroregeneration, neural signaling related to cellular responses and behavior, and synaptic plasticity. Research into the diagnosis, progression, cellular characteristics, and treatment of brain diseases such as Parkinson’s, Multiple Sclerosis, Alzheimer’s, Amyotrophic Lateral Sclerosis and various brain cancers, as well as brain damage resulting from infection, trauma, stroke, seizures, and tumors, is also covered.
