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Neural Cell News is an online resource covering the latest research in neuroscience, neural stem cells, and neurological conditions.
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Gliomas Phenocopy an Inborn Error of Metabolism to Drive Neuronal Activity and Tumor Growth
[Cell] Scientists revealed that glioma-generated guanidinoacetate (GAA) excites surrounding neurons. After depleting tumoral GAA, they found decreased electrochemical activity, neuron-glioma interactions, and tumor aggressiveness.
Architecture of the Serotonergic Projectome in the Mouse Brain
[Cell] Researchers used systematic whole-brain axon tracing and integrated analyses to show that the serotonergic projectome is organized by functional relatedness rather than the physical proximity of its targets.
Cilia Beating of Ependymal Cells Regulates Adult Neural Stem Cell Quiescence via Mechanical Forces Mediated by PKD1/2-TRPM3
[Neuron] The authors developed an approach to transiently inhibit the cilia beating of ependymal cells (ECs) lining the forebrain ventricle, showing that EC cilia beating regulates neural stem cell (NSC) quiescence and activation dynamics.
Inhibitory Circuits Restrain Adult Glioma Progression by Suppressing Calcium-Driven Oncogenic Programs
[Neuron] Investigators showed that adult gliomas receive functional γ-aminobutyric acid synaptic input from local inhibitory interneurons and that this input acts as a tumor-suppressive circuit signal.
Tunneling Nanotubes Regulate Mitochondrial Homeostasis Between Glioblastoma and Astrocytes, and Between Tumor Cells In Vivo
[Nature Communications] The authors showed mitochondrial transfer between Glioblastoma (GBM) cells and non-tumoral astrocytes (AS), finding transfer from GBM cells to AS is associated with activation of mitophagy in recipient cells and AS to GBM transfer is correlated with changes in mitochondrial activity and metabolism.
Astrocytes Mediate the Dopaminergic Modulation of Tonic GABAergic Signaling in Substantia Nigra
[Science Advances] Scientists studied the ability of dopamine to modulate SNr neuron activity in ex vivo mouse brain slices, demonstrating that dopaminergic modulation of astrocytes plays a key role in modulating SNr circuits and motor behavior.
Dendritic Shaft Constrictions Shape Synaptic Integration in Neurons
[Science Advances] Researchers used multiple high-resolution imaging techniques to demonstrate that dendrites in cortical and hippocampal neurons exhibit nanoscale constrictions, termed dendritic shaft constrictions (DSCs), in mice and in human hippocampal and cortical neurons.
Proteasome-Dependent Protein Degradation Shapes Developmental Tempo in Mouse and Human Neural Progenitors
[Developmental Cell] Investigators showed that protein turnover is faster in mouse neural progenitors compared to human, driven by higher rates of protein synthesis and degradation.
CD81 Drives Immune Evasion in Radioresistant Glioblastoma by Blocking Selective Autophagic Degradation of CD274/PD-L1
[Autophagy] The authors used integrative analyses encompassing clinical specimens, public single-cell RNA-seq datasets, orthotopic glioma models, primary CD8+ T cell co-culture systems, and tandem mass tag proteomics to find that CD81 was highly expressed in radioresistant GBM and governed GBM immune evasion.
TRANsCre-DIONE Transdifferentiates Scar-Forming Reactive Astrocytes Into Functional Motor Neurons
[Experimental & Molecular Medicine] Researchers created TRANsCre-DIONE, a dual-promoter split-Cre system combining GFAP and Lcn2 regulatory elements with Cre-dependent Neurog2 expression under the EF1α promoter, enabling selective targeting of scar-forming reactive astrocytes.
RNA Dysregulation As a Determinant of Aging and Neurodegenerative Vulnerability
[Trends in Cell Biology] Scientists summarize recent findings suggesting that aging progressively erodes RNA regulatory fidelity through alterations in RNA-binding protein abundance, localization, biophysical behavior, and RNA interactions, arguing that this is a driver of neuronal vulnerability and neurodegeneration.
Midbrain Organoids As Next-Generation Models for Parkinson’S Disease: From Pathogenesis to Therapeutic Discovery
[Experimental Neurology] The authors examine midbrain organoid-based parkinson's disease modeling through a concept-driven lens, distinguishing established findings from emerging technologies and providing a realistic assessment of current limitations.
Neural Cell News helps scientists keep pace with the latest research, reviews, and industry developments in neuroscience. Specific research topics include neural development and neuroregeneration, neural signaling related to cellular responses and behavior, and synaptic plasticity. Research into the diagnosis, progression, cellular characteristics, and treatment of brain diseases such as Parkinson’s, Multiple Sclerosis, Alzheimer’s, Amyotrophic Lateral Sclerosis and various brain cancers, as well as brain damage resulting from infection, trauma, stroke, seizures, and tumors, is also covered.
