Neural Cell News

Neural Cell News is an online resource covering the latest research in neuroscience, neural stem cells, and neurological conditions.

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Last Patient Has Completed AlzeCure’s Phase Ib Clinical Study with NeuroRestore ACD856

April 20, 2026

[AlzeCure Pharma AB] AlzeCure Pharma AB announced that the last patient’s last visit has now occurred in the ongoing Phase Ib clinical trial of ACD856, the lead drug candidate within the NeuroRestore platform, which is being developed for Alzheimer’s disease and other indications.

Fourth Annual URI Neuroscience Symposium Highlights Dynamic Student Research

April 20, 2026

[Rhody Today] The University of Rhode Island (URI)’s Interdisciplinary Neuroscience Program highlighted student research in a variety of neuroscience specialties at the fourth annual URI Neuroscience Symposium. Students researched such topics as mitochondrial dysfunction and drug-loaded nanoparticles with the ability to penetrate the blood-brain barrier.

Neuron-Derived Mitochondrial DNA (mtDNA) Activates Microglia via the Z-DNA Binding Protein 1 (ZBP1)-Mediated Pathway in Mild Traumatic Brain Injury

April 15, 2026

[Proceedings of the National Academy of Sciences of the United States of America] Using a clinically relevant closed-head weight-drop mouse model, scientists identified mtDNA-specific damage and increased expression of innate inflammatory markers in the cerebral cortex during the acute mild traumatic brain injury phase.

Brain-Derived Neurotrophic Factor Coordinates Neuron-Intrinsic Programs to Enhance Axonal Regeneration in Human Motor Neurons

April 15, 2026

[Science Signaling] Researchers found that the neurotrophin brain-derived neurotrophic factor amplifies multiple neuron-intrinsic programs to foster axonal regeneration in human iPSC-derived lower motor neurons.

Astrocyte-Mediated Higher-Order Control of Synaptic Plasticity

April 15, 2026

[Communications Biology] The authors introduced a higher-order model of the tripartite synapse, accounting for astrocyte-synapse-neuron interactions in short-term plasticity, such that astrocyte gliotransmission and pre-synaptic facilitation jointly modulate neurotransmitter release, generalizing earlier short-term plasticity models.

Identification of CD74-Positive Antigen Presenting Glioma Cells in Primary Human Tumors and Murine Models of NF1 High-Grade Glioma

April 15, 2026

[Molecular Cancer Therapeutics] Scientists generated three distinct glioma stem cell lines from high-grade gliomas arising in mice with Nf1 and Trp53 mutations in cis and characterized the allografts resulting from one Nf1-glioma stem cell line by single cell and single nuclear RNA-seq.

Defining the Functional Role and Potential As an Immunotherapeutic Target of ALCAM in Neuroblastoma

April 15, 2026

[Molecular Cancer Therapeutics] Researchers generated three inducible CRISPR inhibition cell lines to deplete activated leukocyte cell adhesion molecule (ALCAM) and elucidate its role in neuroblastoma.

Small-Molecule PCSK9 Inhibition Enhances BBB Amyloid-β Clearance and Suppresses Microglial Inflammation in Alzheimer’s Disease Models

April 15, 2026

[Scientific Reports] To define the therapeutic relevance of PCSK9 inhibition in Alzheimer’s disease-like pathology, scientists examined SBC-115,076 in AlCl₃-challenged zebrafish larvae and mechanistically validated its effects using complementary endothelial–microglial in vitro models.

Neurokinin Receptor Antagonists for Vasomotor Symptoms: From KNDy Neurons to Clinical Translation

April 15, 2026

[Nature Reviews Endocrinology] The authors synthesize the current understanding of vasomotor symptoms neurobiological pathways, examines translational approaches from preclinical animal models to clinical studies, and discusses the evolution of treatments and mechanism-based interventions.

USC Researchers Awarded NIH Grant to Build a New Model of Hippocampal Neurodegeneration in Alzheimer’s Disease

April 15, 2026

[Keck School of Medicine of USC] A team of researchers at the University of Southern California (USC) Mark and Mary Stevens Neuroimaging and Informatics Institute at the Keck School of Medicine of USC has received a major grant from the National Institutes of Health (NIH) to investigate a long-standing mystery in Alzheimer’s disease.

Cyclerion Therapeutics and Korsana Biosciences Announce Merger Agreement

April 1, 2026

[Cyclerion Therapeutics, Inc.] Cyclerion Therapeutics, Inc. and Korsana Biosciences, Inc., announced that they have entered into a definitive merger agreement for an all-stock transaction.

Oligodendrocyte Precursor Cells-Microglia Crosstalk via BMP4 Drives Microglial Neuroprotective Response and Mitigates Alzheimer’s Disease

April 1, 2026

[Signal Transduction and Targeted Therapy] The authors found that Bmp4 produced by late-stage oligodendrocyte precursor cells, termed committed oligodendrocyte precursors, acts as a critical signal shaping microglial neuroprotective programs in the context of amyloid pathology.

Neural Cell News helps scientists keep pace with the latest research, reviews, and industry developments in neuroscience. Specific research topics include neural development and neuroregeneration, neural signaling related to cellular responses and behavior, and synaptic plasticity. Research into the diagnosis, progression, cellular characteristics, and treatment of brain diseases such as Parkinson’s, Multiple Sclerosis, Alzheimer’s, Amyotrophic Lateral Sclerosis and various brain cancers, as well as brain damage resulting from infection, trauma, stroke, seizures, and tumors, is also covered.