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Neural Cell News is an online resource covering the latest research in neuroscience, neural stem cells, and neurological conditions.
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IGC Pharma Unveils PRISM™ AI Platform to Move Alzheimer’s Risk Prediction to Brain-Health Action and Commercial Deployment
[IGC Pharma, Inc.] IGC Pharma, Inc. announced the introduction of PRISM™, a new application layer designed to bring its patent-pending MINT-AD™ Alzheimer’s AI platform closer to real-world healthcare applications, including early Alzheimer’s risk stratification, cognitive health tracking, clinical trial optimization, and personalized brain-health programs.
Rhode Island Life Science Hub and Cognito Therapeutics Launch Brain Health Collaboratory to Advance Innovation in Alzheimer’s Disease
[Cognito Therapeutics] The Rhode Island Life Science Hub (RILSH) and Cognito Therapeutics announced the launch of the Rhode Island Brain Health Collaboratory, the third Collaboratory in Cognito's growing national network. Together, RILSH and Cognito will partner to establish a first-of-its-kind statewide platform.
NeuroOne® Joins Dartmouth-Led Research Team on $1 Million NIH Grant to Advance Neurotransmitter Sensing Technology
[NeuroOne Medical Technologies Corporation] NeuroOne Medical Technologies Corporation announced it has entered into a research and development subaward agreement with Dartmouth to support the advancement of next-generation neurotransmitter sensing technology.
PTPRS Mediates Invasion of Tetanus Neurotoxin into the Central Nervous System
[Cell] Using pull-down and mass spectrometry analysis, and by developing a luciferase-based in vivo transport assay, researchers identified receptor protein tyrosine phosphatase sigma (PTPRS) as the retrograde transport receptor for tetanus neurotoxin.
Single-Cell Profiling and Genetic Regulation of Alternative Polyadenylation in the Human Brain
[Nature Genetics] Scientists reported a single-cell atlas of alternative polyadenylation of the aged human brain across two million cells from 379 human postmortem brains across individuals with and without Alzheimer’s disease.
Genome-Wide Analysis of Common Structural Variants in Alzheimer’s Disease Identifies a Risk-Associated Regulatory CCG Repeat in FAM193B
[Nature Neuroscience] Using long-read and short-read sequencing data from the Chinese population, the authors showed that common structural variants contribute to Alzheimer's diseases heritability beyond common single-nucleotide polymorphisms.
Striatal Astrocyte μ-Crystallin (Crym) Loss Contributes to Early-Stage Huntington’s Disease Pathophysiology
[Neuron] Researchers found that astrocytic μ-crystallin gene (Crym) and μ-crystallin protein expression levels are reduced in human Huntington’s disease (HD) tissue, cerebrospinal fluid, and HD mouse models.
3D Bioprinted Blood-Brain-Tumor Barrier Spheroid-Based In Situ Evaluation of Anticancer Compounds against Glioblastoma: ROS-Producing Ruthenium as a Potential Therapeutic Candidate
[Advanced Science] Investigators introduced a brain tumor-mimicking blood–brain–tumor barrier (BBTB) spheroid that enables in situ measurement of BBTB permeability to anticancer agents and the subsequent induction of cancer cell death at the single-cell level within intact spheroids.
Brain DNA Methylation, APOE Genotype, and Alzheimer’s Disease Neuropathology in a Large Postmortem Cohort
[Nature Aging] The authors profiled DNA methylation in 1,250 postmortem prefrontal cortex samples from the Rush Alzheimer’s Disease (AD) cohorts and performed epigenome-wide association studies of multiple neuropathologic measures, including AD diagnosis, amyloid-β and tau tangles.
Development of a Messenger RNA Therapy for Schizophrenia
[Biological Psychiatry] Researchers defined candidate drug targets as genes linked to schizophrenia, performed clinical validation of candidate targets, confirmed molecular effects of clinically validated targets and developed a messenger RNA drug for one validated target.
Astrocytic Facilitation of Somatic NMDARs Underpins Hippocampal E-S Potentiation
[Proceedings of the National Academy of Sciences of the United States of America] Scientists showed that brief induction of EPSP–spike (E-S) potentiation triggers a sustained calcium activity increase in astrocytes adjacent to the hippocampal CA1 pyramidal layer.
Highly Potent, Brain-Penetrant EP2 Receptor Antagonists for the Treatment of Permanent Focal Cerebral Ischemia in Male and Female Mice
[British Journal of Pharmacology] Researchers characterized the pharmacokinetic parameters of selective EP2 antagonists CJ-18, CJ-19 and CJ-21 that they recently developed, evaluating their therapeutic efficacy in mice and examining the effects of EP2 inhibition in neuron–glia mixed cultures.
Neural Cell News helps scientists keep pace with the latest research, reviews, and industry developments in neuroscience. Specific research topics include neural development and neuroregeneration, neural signaling related to cellular responses and behavior, and synaptic plasticity. Research into the diagnosis, progression, cellular characteristics, and treatment of brain diseases such as Parkinson’s, Multiple Sclerosis, Alzheimer’s, Amyotrophic Lateral Sclerosis and various brain cancers, as well as brain damage resulting from infection, trauma, stroke, seizures, and tumors, is also covered.
