Neural Cell News

Neural Cell News is an online resource covering the latest research in neuroscience, neural stem cells, and neurological conditions.

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Sarepta Therapeutics Announces Approval of Clinical Trial Application for SRP-1005, Its Investigational Treatment for Huntington’s Disease

February 4, 2026

[Sarepta Therapeutics, Inc.] Sarepta Therapeutics, Inc. announced that Medsafe, the New Zealand Medicines and Medical Devices Safety Authority, has granted approval for its clinical trial application for Study SRP-1005-101, also known as INSIGHTT. SRP-1005 is an investigational small interfering RNA therapeutic for the treatment of Huntington's Disease.

A First-in-Class Small-Molecule Inhibitor Targeting AVIL Exhibits Safety and Antitumor Efficacy in Preclinical Models of Glioblastoma

February 4, 2026

[Science Translational Medicine] Investigators further examined advillin (AVIL) expression in glioblastomas (GBMs) and found that it was enriched across molecular subtypes and states, including GBM stem cells and temozolomide-resistant samples.

Olig2 Acts As an Inducible Barrier to In Vivo Astrocyte-to-Neuron Conversion

February 4, 2026

[Nature Communications] Scientists identified Olig2, a basic helix-loop-helix transcription factor, as an inducible barrier to Ngn2-mediated AtN conversion. Olig2 is strongly upregulated in cortical astrocytes following the ectopic expression of bHLH neuronal reprogramming factors.

RIN3 Mutations Impairing Binding of the Alzheimer’s Disease-Associated Protein BIN1 Lead to RAB5 Hyperactivation and Endosomal Pathology

February 4, 2026

[Science Advances] Investigators demonstrated a direct role for RIN3 in RAB5 activation and endosomal enlargement, which is negatively regulated by BIN1 in neurons

Monitoring Glioblastoma Extracellular Vesicle Evolution Using a Nanodiagnostic Platform to Detect Glioma Stem Cells Driving Recurrent Disease

February 4, 2026

[Science Advances] To address the need for monitoring tumor evolution and therapeutic resistance, researchers developed a glioblastoma (GBM) biomarker panel for multiplexed profiling of small extracellular vesicles using an advanced GBM Extracellular Vesicle Monitoring Phenotypic Analyzer Chip.

Drospondin, a Glial Glycoprotein with Similarities to Human Reelin/F-Spondin, Contributes to Brain Development, and Function

February 4, 2026

[Proceedings of the National Academy of Sciences of the United States of America] Scientists reported that the protein product of the uncharacterized Drosophila CG17739 gene, which they named Drospondin, shares sequence homology with vertebrate F-spondin and Reelin.

Astrocyte Senescence Impairs Synaptogenesis Due to Thrombospondin-1 Loss

February 4, 2026

[Aging Cell] The authors reported an early onset of senescence signatures in hippocampal astrocytes of the accelerated aging and frailty mouse model SAMP8.

Astrocytic TCF7L2 Impacts Brain Osmoregulation and Restricts Neuronal Excitability

February 4, 2026

[Glia] Researchers investigated the role of Wnt/β-catenin signaling and its effector, the transcription factor TCF7L2, in postnatal astrocytes using single-nucleus RNA sequencing, imaging, morphometric analysis, microdialysis, and electrophysiology in Tcf7l2 conditional knockout mice.

Fucosyltransferase 8 Facilitates EMT in Glioblastoma Cells through the Remodelling of TGF-β Receptor Core Fucosylation

February 4, 2026

[Open Biology] Scientists demonstrated that fucosyltransferase 8 (FUT8) expression was upregulated in glioblastoma (GBM) compared with low-grade gliomas. FUT8 knockdown inhibited transforming growth factor-β (TGF-β)-induced epithelial–mesenchymal transition (EMT), whereas FUT8 overexpression promoted TGF-β-induced EMT in vitro and in vivo.

Human Myelin Spheres for In Vitro Oligodendrocyte Maturation, Myelination, and Neurological Disease Modeling

February 4, 2026

[Stem Cell Reviews and Reports] Investigators presented a novel method to generate human myelin spheres by coculturing of hPSC-derived neuronal and oligodendrocyte precursor cells, to create myelinated neurons.

Key Methylation Modifications in Glioma Stem Cells

February 4, 2026

[Biochimica Et Biophysica Acta-Reviews On Cancer] Scientists explore the dynamics of methylation in glioma stem cells (GSCs), encompassing the latest research on DNA, RNA, and protein methylation within the field of GSCs.

Interplay Between Hypoxia-Inducible Factors and Apoptosis in Glioblastoma

February 4, 2026

[Biochemical Pharmacology] The authors summarize recent advances in our understanding of the HIF–apoptosis axis in glioblastoma and discuss potential therapeutic strategies that target this molecular crosstalk.

Neural Cell News helps scientists keep pace with the latest research, reviews, and industry developments in neuroscience. Specific research topics include neural development and neuroregeneration, neural signaling related to cellular responses and behavior, and synaptic plasticity. Research into the diagnosis, progression, cellular characteristics, and treatment of brain diseases such as Parkinson’s, Multiple Sclerosis, Alzheimer’s, Amyotrophic Lateral Sclerosis and various brain cancers, as well as brain damage resulting from infection, trauma, stroke, seizures, and tumors, is also covered.