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Neural Cell News is an online resource covering the latest research in neuroscience, neural stem cells, and neurological conditions.
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Zebrafish Oligodendrocyte Lineage Cells Use the Postsynaptic Protein Gephyrin to Myelinate GABAergic Axons and Limit Myelin Sheath Growth
[Nature Communications] The authors examined whether the inhibitory postsynaptic scaffold protein Gephyrin mediates selective myelination of specific axon classes in the larval zebrafish.
Therapeutic Targeting of the Conserved Region Within the Low-Complexity Domain of TDP-43 Is Neuroprotective and Extends Survival in Amyotrophic Lateral Sclerosis Mice
[Nature Aging] Investigators showed that the conserved α-helical region spanning residues 320–340 is a therapeutically actionable target for TAR DNA-binding protein 43 (TDP-43) neurotoxicity.
Glioblastoma Stem Cell Growth Requires DOT1L-MED23 Control of Enhancer Accessibility
[Cell Reports] Scientists showed that the histone methyltransferase DOT1L shapes chromatin accessibility of glioblastoma stem cell enhancer elements to reversibly regulate fate- and growth-related transcriptional programs.
A Non-Catalytic Function for RAD18 in Sustaining Glioblastoma Proliferation
[Cell Reports] Researchers showed that RAD18 promotes glioblastoma cell proliferation in the absence of exogenous damage, independently of its catalytic activity.
SGK1-Mediated Deficits in Microglial Phagocytosis Drive Pathological Progression in Amyotrophic Lateral Sclerosis
[Journal of Neuroinflammation] Scientists provided evidence for a previously unrecognized role of serum- and glucocorticoid-regulated kinase 1 (SGK1) in regulating microglial phagocytosis in ALS models and support SGK1 as a potential therapeutic target in SOD1 mutation-associated ALS models.
ANXA2+/TNR– Glioblastoma Subpopulation Drives Tumor Progression through via Src-STAT3 Axis and Neutrophil Remodeling
[International Immunopharmacology] Investigators employed single-cell RNA sequencing, flow cytometry, and in vitro functional assays to identify and characterize an ANXA2+/TNR− subpopulation in glioblastoma.
Modeling Glioblastoma Niche-by-Niche: Recent Advancements in Bioengineering of Organotypic Models of Glioblastoma for Precision Medicine
[Biofabrication] The authors examine advances from the past five years in bioengineered microphysiological systems for glioblastoma, with an emphasis on platforms designed to capture tumor heterogeneity, microenvironmental regulation, and therapeutic response.
Feinstein Institutes Secures $4.9M in NIH Grants to Advance Research in Acute Inflammation and Alzheimer’s Disease
[Feinstein Institutes] Northwell Health's Feinstein Institutes for Medical Research has received $4.9 million in National Institutes of Health (NIH) funding to advance research into the cellular mechanisms underlying acute inflammation and Alzheimer's disease.
Oligomerix Awarded $1.9 M NIH Phase II SBIR Fast-Track Grant to Conduct Safety Studies Required for Clinical Studies of OLX-07010 in Alzheimer’s Patients
[Oligomerix, Inc. (Business Wire)] Oligomerix, Inc. announced an National Institutes of Health (NIH) Fast Track Phase II award of $1.9 million from the National Institute on Aging of the NIH.
Confined Migration Induces Non-Lethal DNA Damage in Developing Neurons
[Nature] Researchers found that neurons routinely sustain DNA breaks during cortex formation, but a rapid repair system corrects the damage before harm occurs.
EGR1 Mediates Neuronal Damage via Suppressing HIF1A-Induced Mitophagy Following Traumatic Brain Injury
[Autophagy] Using integrated transcriptomic and epigenomic analyses, scientists identified EGR1 as a critical regulator of traumatic brain injury pathology, with its expression acutely upregulated in neurons post-injury.
The EMB/ATG7-Mediated Autophagic Process Regulates Neurite Outgrowth and Promotes Enteric Neuronal Development
[Proceedings of the National Academy of Sciences of the United States of America] Investigators identified embigin (EMB) as a critical regulator of enteric neuronal maturation. In EMB mutant patients, the expression of EMB is reduced in the enteric neurons of the hypoganglionosis-affected colon.
Neural Cell News helps scientists keep pace with the latest research, reviews, and industry developments in neuroscience. Specific research topics include neural development and neuroregeneration, neural signaling related to cellular responses and behavior, and synaptic plasticity. Research into the diagnosis, progression, cellular characteristics, and treatment of brain diseases such as Parkinson’s, Multiple Sclerosis, Alzheimer’s, Amyotrophic Lateral Sclerosis and various brain cancers, as well as brain damage resulting from infection, trauma, stroke, seizures, and tumors, is also covered.
