Cancer Stem Cell News Volume 11.23 | June 15 2022

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    2022-06-15 | CSCN “.


    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 11.23 – 15 June, 2022
    TOP STORY

    DTX-P7, a Peptide–Drug Conjugate, Is Highly Effective for Non-Small Cell Lung Cancer

    Investigators constructed a cooperatively combating conjugate (DTX-P7) composed of docetaxel (DTX) and a heptapeptide, which specifically bound to cell surface Hsp90, and assessed the anti-tumor effects of DTX-P7 on non-small cell lung cancer.
    [Journal of Hematology & Oncology]

    Full ArticleGraphical Abstract
    Virtual Conference Exhibition: Pluripotent Stem Cells
    PUBLICATIONSRanked by the impact factor of the journal

    Differentiated Glioma Cell-Derived Fibromodulin Activates Integrin-Dependent Notch Signaling in Endothelial Cells to Promote Tumor Angiogenesis and Growth

    Proteomic analysis showed a higher abundance of the extracellular matrix small leucine-rich proteoglycan Fibromodulin in the conditioned medium of differentiated glioma cells, the equivalent of glioma non-CSCs, compared to that of glioma stem-like cells.
    [eLife]

    Abstract

    Testicular Cancer in Mice: Interplay between Stem Cells and Endocrine Insults

    Neonatal DES exposure affected testicular very small embryonic-like stem cells and spermatogonial stem cells and resulted in infertility, reduced sperm counts, and tumor-like changes leading to the postulate that testicular dysgenesis syndrome possibly has a stem cell basis.
    [Stem Cell Research & Therapy]

    Full Article

    Characterization of Stem Cell Landscape and Identification of Stemness-Relevant Prognostic Gene Signature to Aid Immunotherapy in Colorectal Cancer

    Investigators characterized the stemness landscapes and screen for certain patients more responsive to immunotherapy.
    [Stem Cell Research & Therapy]

    Full Article

    AMP-Activated Protein Kinase Promotes Breast Cancer Stemness and Drug Resistance

    The authors investigated the role of AMP-activated protein kinase in the maintenance of breast CSCs state/function.
    [Disease Models & Mechanisms]

    Abstract

    Silencing PLOD2 Attenuates Cancer Stem Cell-Like Characteristics and Cisplatin-Resistant through Integrin β1 in Laryngeal Cancer

    The effects of PLOD2 expression on ordinary and Cisplatin-resistance cells were investigated in TU686 and TU138 cells and Xenograft model.
    [Translational Oncology]

    Abstract

    Effect of Chronic Intermittent Hypoxia-Induced HIF-1α/ATAD2 Expression on Lung Cancer Stemness

    Researchers evaluated the relative expression of AAA domain-containing protein 2 (ATAD2) in four lung cancer cell lines and found increased mRNA and protein levels of ATAD2 in lung cancer samples.
    [Cellular & Molecular Biology Letters]

    Full Article

    TRG16, Targeted by miR-765, Inhibits Breast Cancer Stem Cell-Like Properties via Regulating the NF-κB Pathway

    The authors found that TRG16 expression was significantly downregulated in breast cancer (BC) tissues compared with adjacent tissues and BC patients with lower expression of TRG16 had a worse prognosis.
    [Molecular and Cellular Biochemistry]

    AbstractGraphical Abstract

    Comparative Effects of Vacuum or Conventional Frying on the Polyphenol Chemistry and In Vitro Colon Cancer Stem Cell Inhibitory Activity of Purple-Flesh Potatoes

    Researchers examined the impacts of reconditioning and frying method on phenolic chemistry and in vitro colon CSC inhibitory activity of purple-flesh potato chips.
    [Journal of Food Science]

    Abstract
    How to prioritize and manage your research projects
    REVIEWS

    Oncofetal Proteins and Cancer Stem Cells

    Scientists summarize the common pluripotent transcription factors such as OCT4, SOX2, NANOG, KLF4, MYC, SALL4, and FOXM1, as well as the development signaling including Wnt/β-catenin, Hedgehog, Hippo, Notch, and TGF-β pathways of embyronic stem cells and CSCs.
    [Essays in Biochemistry]

    Abstract

    Characteristics of the Cancer Stem Cell Niche and Therapeutic Strategies

    The authors summarize and discuss the latest findings regarding CSC niche morphology, physical terrain, main signaling pathways and interactions within them.
    [Stem Cell Research & Therapy]

    Full Article

    INDUSTRY AND POLICY NEWS

    Immunicum AB: Immunicum Received FDA Orphan Drug Designation for Ilixadencel as Treatment of Gastrointestinal Stromal Tumors (GIST)

    Immunicum AB announced that it has been granted an orphan drug designation from the US FDA for ilixadencel in the treatment of GIST, a rare and difficult to treat subgroup of cancers reffered to as soft tissue sarcoma.
    [Immunicum AB]

    Press Release

    Nammi Therapeutics Granted FDA Orphan Drug Designation for QXL138AM for the Treatment of Multiple Myeloma

    Nammi Therapeutics, Inc. announced that the FDA has granted orphan drug designation to its lead program, QXL138AM, for the treatment of multiple myeloma.
    [Nammi Therapeutics, Inc. (Cision US Inc.)]

    Press Release
    FEATURED EVENT

    EASL NAFLD Summit 2022

    September 15 – September 17
    Dublin, Ireland, United Kingdom

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Position – Cancer Biology and Immunotherapies

    Sanford Research – Sioux Falls, South Dakota, United States

    Scientific Editor – Blood Cancer Discovery

    American Association for Cancer Research – Various, United States

    Research Assistant – Melanoma Medical Oncology

    University of Texas MD Anderson Cancer Center – Houston, Texas, United States

    Postdoctoral Candidate – Cancer Biology

    German Cancer Research Center in the Helmholtz Association – Heidelberg, Germany

    Postdoctoral Fellow – Cancer Immunology & Genomics

    La Jolla Institute for Immunology – La Jolla, California, United States

    > See All Jobs

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