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Vol. 11.23 – 15 June, 2022
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Investigators constructed a cooperatively combating conjugate (DTX-P7) composed of docetaxel (DTX) and a heptapeptide, which specifically bound to cell surface Hsp90, and assessed the anti-tumor effects of DTX-P7 on non-small cell lung cancer. [Journal of Hematology & Oncology]
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PUBLICATIONSRanked by the impact factor of the journal
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Proteomic analysis showed a higher abundance of the extracellular matrix small leucine-rich proteoglycan Fibromodulin in the conditioned medium of differentiated glioma cells, the equivalent of glioma non-CSCs, compared to that of glioma stem-like cells.
[eLife]
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Neonatal DES exposure affected testicular very small embryonic-like stem cells and spermatogonial stem cells and resulted in infertility, reduced sperm counts, and tumor-like changes leading to the postulate that testicular dysgenesis syndrome possibly has a stem cell basis.
[Stem Cell Research & Therapy]
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Investigators characterized the stemness landscapes and screen for certain patients more responsive to immunotherapy.
[Stem Cell Research & Therapy]
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The authors investigated the role of AMP-activated protein kinase in the maintenance of breast CSCs state/function.
[Disease Models & Mechanisms]
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The effects of PLOD2 expression on ordinary and Cisplatin-resistance cells were investigated in TU686 and TU138 cells and Xenograft model.
[Translational Oncology]
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Researchers evaluated the relative expression of AAA domain-containing protein 2 (ATAD2) in four lung cancer cell lines and found increased mRNA and protein levels of ATAD2 in lung cancer samples.
[Cellular & Molecular Biology Letters]
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The authors found that TRG16 expression was significantly downregulated in breast cancer (BC) tissues compared with adjacent tissues and BC patients with lower expression of TRG16 had a worse prognosis.
[Molecular and Cellular Biochemistry]
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Researchers examined the impacts of reconditioning and frying method on phenolic chemistry and in vitro colon CSC inhibitory activity of purple-flesh potato chips. [Journal of Food Science]
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Scientists summarize the common pluripotent transcription factors such as OCT4, SOX2, NANOG, KLF4, MYC, SALL4, and FOXM1, as well as the development signaling including Wnt/β-catenin, Hedgehog, Hippo, Notch, and TGF-β pathways of embyronic stem cells and CSCs.
[Essays in Biochemistry]
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The authors summarize and discuss the latest findings regarding CSC niche morphology, physical terrain, main signaling pathways and interactions within them.
[Stem Cell Research & Therapy]
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Immunicum AB announced that it has been granted an orphan drug designation from the US FDA for ilixadencel in the treatment of GIST, a rare and difficult to treat subgroup of cancers reffered to as soft tissue sarcoma.
[Immunicum AB]
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Nammi Therapeutics, Inc. announced that the FDA has granted orphan drug designation to its lead program, QXL138AM, for the treatment of multiple myeloma. [Nammi Therapeutics, Inc. (Cision US Inc.)]
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September 15 – September 17 Dublin, Ireland, United Kingdom
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Sanford Research – Sioux Falls, South Dakota, United States
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American Association for Cancer Research – Various, United States
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University of Texas MD Anderson Cancer Center – Houston, Texas, United States
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German Cancer Research Center in the Helmholtz Association – Heidelberg, Germany
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La Jolla Institute for Immunology – La Jolla, California, United States
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