 | | Vol. 11.23 – 15 June, 2022 |
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| Investigators constructed a cooperatively combating conjugate (DTX-P7) composed of docetaxel (DTX) and a heptapeptide, which specifically bound to cell surface Hsp90, and assessed the anti-tumor effects of DTX-P7 on non-small cell lung cancer.
[Journal of Hematology & Oncology] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Proteomic analysis showed a higher abundance of the extracellular matrix small leucine-rich proteoglycan Fibromodulin in the conditioned medium of differentiated glioma cells, the equivalent of glioma non-CSCs, compared to that of glioma stem-like cells.
[eLife] |
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| Neonatal DES exposure affected testicular very small embryonic-like stem cells and spermatogonial stem cells and resulted in infertility, reduced sperm counts, and tumor-like changes leading to the postulate that testicular dysgenesis syndrome possibly has a stem cell basis.
[Stem Cell Research & Therapy] |
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| Investigators characterized the stemness landscapes and screen for certain patients more responsive to immunotherapy.
[Stem Cell Research & Therapy] |
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| The authors investigated the role of AMP-activated protein kinase in the maintenance of breast CSCs state/function.
[Disease Models & Mechanisms] |
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| The effects of PLOD2 expression on ordinary and Cisplatin-resistance cells were investigated in TU686 and TU138 cells and Xenograft model.
[Translational Oncology] |
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| Researchers evaluated the relative expression of AAA domain-containing protein 2 (ATAD2) in four lung cancer cell lines and found increased mRNA and protein levels of ATAD2 in lung cancer samples.
[Cellular & Molecular Biology Letters] |
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| The authors found that TRG16 expression was significantly downregulated in breast cancer (BC) tissues compared with adjacent tissues and BC patients with lower expression of TRG16 had a worse prognosis.
[Molecular and Cellular Biochemistry] |
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| Researchers examined the impacts of reconditioning and frying method on phenolic chemistry and in vitro colon CSC inhibitory activity of purple-flesh potato chips.
[Journal of Food Science] |
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| Scientists summarize the common pluripotent transcription factors such as OCT4, SOX2, NANOG, KLF4, MYC, SALL4, and FOXM1, as well as the development signaling including Wnt/β-catenin, Hedgehog, Hippo, Notch, and TGF-β pathways of embyronic stem cells and CSCs.
[Essays in Biochemistry] |
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| The authors summarize and discuss the latest findings regarding CSC niche morphology, physical terrain, main signaling pathways and interactions within them.
[Stem Cell Research & Therapy] |
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| Immunicum AB announced that it has been granted an orphan drug designation from the US FDA for ilixadencel in the treatment of GIST, a rare and difficult to treat subgroup of cancers reffered to as soft tissue sarcoma.
[Immunicum AB] |
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| Nammi Therapeutics, Inc. announced that the FDA has granted orphan drug designation to its lead program, QXL138AM, for the treatment of multiple myeloma.
[Nammi Therapeutics, Inc. (Cision US Inc.)] |
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| September 15 – September 17
Dublin, Ireland, United Kingdom |
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| | Sanford Research – Sioux Falls, South Dakota, United States |
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| | American Association for Cancer Research – Various, United States |
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| | University of Texas MD Anderson Cancer Center – Houston, Texas, United States |
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| | German Cancer Research Center in the Helmholtz Association – Heidelberg, Germany |
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| | La Jolla Institute for Immunology – La Jolla, California, United States |
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