Differentiated Glioma Cell-Derived Fibromodulin Activates Integrin-Dependent Notch Signaling in Endothelial Cells to Promote Tumor Angiogenesis and Growth

Proteomic analysis showed a higher abundance of the extracellular matrix small leucine-rich proteoglycan Fibromodulin in the conditioned medium of differentiated glioma cells, the equivalent of glioma non-CSCs, compared to that of glioma stem-like cells.