 | | Vol. 23.32 – 19 September, 2022 |
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| Single-cell proteomic profiling of circulating CAR T cells in 32 patients treated with CD19-CAR identified that CD4+Helios+ CAR T cells on day seven after infusion were associated with progressive disease and less severe neurotoxicity.
[Nature Medicine] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Autologous T cells from patients with systemic lupus erythematosus were transduced with a lentiviral anti-CD19 CAR vector, expanded and reinfused at a dose of 1 × 106 CAR T cells per kilogram of body weight into the patients after lymphodepletion with fludarabine and cyclophosphamide.
[Nature Medicine] |
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| Investigators transplanted GFP-expressing sex-matched, sex-mismatched, or mixed donor cells into sites of spinal cord injury in adult male and female mice.
[Nature Communications] |
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| miR-218 was used as an osteogenic miRNA regulator, and a multifunctional peptide-conjugated gene carrier was developed to condense with miR-218 to form PPP-RGI/miR-218 complexes that were further encapsulated into monodisperse injectable microspheres for enhanced bone regeneration.
[ACS Applied Materials & interfaces] |
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| Non-relapse mortality, disease relapse/progression, progression-free surviva, and overall survival were modeled using Cox proportional hazards models.
[British Journal of Haematology] |
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| Scientists investigated the efficacy of a combination of anti-PD1/PD-L1 and dendritic cell therapy to optimally induce effective anti-tumor immunity in malignant pleural mesothelioma in both humans and mice.
[International Journal of Cancer] |
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| Researchers generated good manufacturing practice-compatible neural progenitor cells from transgene- and xeno-free induced pluripotent stem cells that could be smoothly adapted for clinical applications.
[Journal of Translational Medicine] |
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| Scientists investigated double knockdown of IL-6 and IFN-γ as a potential strategy to manage anti-CD19 CAR-T cell-associated cytokine release syndrome.
[Human Vaccines & Immunotherapeutics] |
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| The authors showed that 3-deazaadenosine, an S-adenosyl homocysteinase inhibitor, alleviated replicative and oncogene-induced senescence.
[Nature Aging] |
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| Investigators systematically introduce the components of different generations of CARs and summarize recent innovations in nano-based CAR-T cell therapy to conquer therapeutically resistant non-hematologic malignancies.
[Pharmacological Research] |
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| Marker Therapeutics, Inc. announced that the company has been awarded a $2 million grant from the US FDA Orphan Products Grants program to support its Phase II ARTEMIS trial of its lead multi-tumour-associated antigen T cell product candidate in patients with post-transplant acute myeloid leukemia (AML).
[Marker Therapeutics, Inc.] |
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| Northwestern University Feinberg School of Medicine and the Simpson Querrey Institute for Epigenetics announced that CRISPR pioneer and Nobel Laureate Jennifer Doudna, PhD has received the inaugural $250,000 Kimberly Prize in Biochemistry and Molecular Genetics.
[Northwestern University] |
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| December 3 – 7, 2022
Washington, DC, United States |
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| | Cardiff University – Cardiff, Wales, United Kingdom |
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| | Celsius Therapeutics – Cambridge, Massachusetts, United States |
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| | Princess Margaret Cancer Centre, University of Toronto – Toronto, Ontario, Canada |
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| | Leiden University Medical Center – Leiden, Netherlands |
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| | St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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