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| The authors established a doxycycline-titratable system for genetic induction of permanent intratumor expression of KDM5B and screened for chemical agents that phenocopy this effect.
[Nature Communications] |
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|
 | | PUBLICATIONSRanked by the impact factor of the journal |
| | DERMAL STEM CELLS & TISSUE REGENERATION |
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| The polarization of M2 macrophages transduced by the acid-sensing ion channel 3 (ASIC3)-macrophage colony-stimulating factor (M-CSF) signal promoted the differentiation of fibroblasts into myofibroblasts through transforming growth factor β1 (TGF-β1), thereby producing an ASIC3-M-CSF-TGF-β1 positive feedback loop.
[Cell Death & Disease] |
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| Researchers succeeded in visualizing collagen-producing cells and produced collagen using the axolotl skin, which is highly transparent. The visualized dermal collagen had a lattice-like structure.
[iScience] |
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| The purpose of this study was to standardize 3-D imaging and quantification for the evaluation of epidermal melanocytes.
[Pigment Cell & Melanoma Research] |
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| Researchers found a significant downregulation of secreted frizzled-related protein 1 (SFRP1) in HaCaT, A431, and SCL-1 cells after ultraviolet radiation B (UVB) irradiation.
[Experimental Dermatology] |
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| Knockdown of VDAC1 increased free cytosolic Ca2+ in cultured melanocytes at the resting state, which activated calcineurin through the Ca2+-calmodulin-CaN pathway.
[Life Science Alliance] |
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| | Scientists proposed a nanoinducer based on a functional dermatan sulfate (DS) for melanoma. This nanosystem is composed of DS as framework, aromatic thioketal derivative as functional grafting unit and doxorubicin designed as an immunogenic cell death inducer.
[Journal of Controlled Release] |
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| In vitro, the effect of the combination regimen of vemurafenib and b-AP15 on vem-sensitive and vem-resistant melanoma has been investigated by wound healing, colony formation, transwell invasion assay, flow cytometry, lysosome staining, and ROS detection.
[Cell Biology and Toxicology] |
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| In a 3D multicellular system, obtained co‑culturing melanoma cancer cells with stromal cells, including ECs, melanoma ALDH1A1 overexpression induced the recruitment of ECs into the core of the tumorspheres.
[International Journal of Molecular Medicine] |
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| The characteristics of non-melanoma carcinoma is discussed, describing the main existing treatments, together with the contribution of lipid delivery systems as an innovative approach to increase the effectiveness of topical therapies for non-melanoma carcinomas.
[Neoplasia] |
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| OliX Pharmaceuticals, Inc. announced the completion of patient enrollment in the Phase IIa clinical trial of OLX101A, an investigational therapeutic program for the treatment of hypertrophic scar.
[OliX Pharmaceuticals, Inc. (Business Wire)] |
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| September 29 – September 30, 2022
London, England, United Kingdom |
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| | University of Gothenburg – Gothenburg, Sweden |
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| | Oslo University Hospital – Oslo, Norway |
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| | University of Texas MD Anderson Cancer Center – Houston, Texas, United States |
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| | University of Texas MD Anderson Cancer Center – Houston, Texas, United States |
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