 | | Vol. 17.32 – 17 August, 2022 |
| |
|
|
| Researchers found ultraviolet light-related damage in ~72% of skin fibroblast-derived hiPSCs, occasionally resulting in substantial mutagenesis.
[Nature Genetics] |
|
|
|
 | | PUBLICATIONSRanked by the impact factor of the journal |
|
|
|
| Scientists presented a screening platform to systematically elucidate functional consequences of genetic perturbations in hiPSC-derived microglia.
[Nature Neuroscience] |
|
|
|
| Researchers presented a comprehensive single-cell transcriptome, methylome, and small RNA atlas in the day seven human embryo.
[Genome Research] |
|
|
|
| The authors characterized the MHC I-associated peptide (MAP) repertoire of hiPSCs using proteogenomics. Their analyses revealed a set of 46 pluripotency-associated MAPs absent from the transcriptome of normal tissues and adult stem cells but expressed in PSCs and multiple adult cancers.
[Cell Reports] |
|
|
|
| Bulk and single-cell-based assays were employed to catalog gene expression, histone modifications, chromatin conformation, and accessibility transitions in ESC populations and individual cells acquiring a presomitic mesoderm fate.
[Cell Reports] |
|
|
|
| Investigators established a potential therapeutic strategy for motor neuron diseases by in vivo directional differentiation of hiPSCs engineered with motor neuron specific transcription factors and Tet-On system.
[Cell Proliferation] |
|
|
|
| Using a seven-stage protocol, hiPSCs were differentiated into islet-like aggregates with a yield of insulin-positive beta cells comparable to that of human islets.
[Frontiers in Cell and Developmental Biology] |
|
|
|
| The authors used hiPSC derived intestinal epithelial cells, grown as a cell layer, to study the effects of butyrate, propionate, and acetate on whole genome gene expression in the cells.
[Scientific Reports] |
|
|
|
| Scientists studied transcriptome, chromatin accessibility, active histone modification marks, and relative proteomes of ESCs and the two well-established expanded potential stem cells (EPSCs) lines to probe the molecular foundation underlying EPSC developmental potential.
[Life Science Alliance] |
|
|
|
| Researchers developed hiPSC-engineered niches to reveal druggable cancer-niche dependencies. They revealed that mesenchymal and vascular niche-like hiPSC-derived cells supported ex vivo proliferation of patient-derived leukemia cells, affect dormancy, and mediated treatment resistance.
[Cell Reports Medicine] |
|
|
|
|
| The authors discuss the use of hiPSCs as a model for Parkinson’s disease pathology and research on the Leucine-Rich Repeat Kinase 2 (LRRK2) function in both neuronal and immune cells, together with reviewing the recent advances in 3D organoid models and microfluidics.
[Neurobiology of Disease] |
|
|
|
|
| The race to decide who will become the new leader of the UK Conservative Party, and the country’s next Prime Minister, has less than a month left to run.
[Nature] |
|
|
|
|
| November 2 – 4, 2022
Lyon, France |
|
|
|
|
|
| | Oklahoma Medical Research Foundation – Oklahoma City, Oklahoma, United States |
|
|
|
| | National University of Ireland Galway – Galway, Ireland |
|
|
|
| | Shenzhen Institute of Advanced Technology – Shenzhen, China |
|
|
|
| | University of Calgary – Calgary, Alberta, Canada |
|
|
|
| | Yale University – New Haven, Connecticut, United States |
|
|
|
|
Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
