 | | Vol. 13.23 – 14 June, 2022 |
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| Mechanistically, reticulocalbin-2 binds to a functional receptor complex, which is composed of neuronilin-2 and integrin beta-1, to activate a cAMP-PKA signaling pathway that mobilizes bone marrow fat via lipolysis to fuel the differentiation and function of mesenchymal and hematopoietic stem cells.
[Cell Metabolism] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| In combination with adeno-associated virus serotype 6 template delivery, the authors’ approach led to efficient HDR in human hematopoietic stem and progenitor cells and T cells, with minimal NHEJ-mediated on-target mutations.
[Science Advances] |
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| Scientists comprehensively mapped the naked mole rat hematopoietic landscape and identified unique features likely contributing to longevity.
[EMBO Journal] |
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| Researchers showed that, in the absence of CLASP2, a microtubule-associated protein, the overall production of hematopoietic stem cells (HSCs) was reduced, and the produced HSCs failed to self-renew and maintain their stemness throughout mouse and zebrafish development.
[Cell Reports] |
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| Scientists demonstrated that Fbxw11 plays a negative role in the maintenance of hematopoietic stem/progenitor cells in vitro and repopulation capacity in vivo.
[Stem Cell Research & Therapy] |
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| Investigators identified three miRNAs, miR-146a-5p, miR-181b-5p, and miR-199b-3p, as potential candidates for TLR8 ligation, which are overexpressed in acute lymphoblastic leukemia and show agonist functional binding.
[Journal of Leukocyte Biology] |
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| The authors demonstrated that human committed hematopoietic progenitors could be reprogrammed into multipotent progenitors by spliceosome inhibitor.
[Experimental Hematology & Oncology] |
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| Using conditional in vivo models of steady state and acute Padi4 ablation, researchers examined the role of PADI4 in the development and function of the hematopoietic system.
[Biology Open] |
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| Scientists investigated the longitudinal dynamics of the gut microbiota and metabolome and potential associations to clinical outcomes in pediatric hematopoietic stem cell transplantation at a single center.
[Microbiome] |
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| Researchers summarize current knowledge on the cellular composition of the human bone marrow niche after hematopoietic cell transplantation.
[Bone Marrow Transplantation] |
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| Nammi Therapeutics, Inc. announced that the FDA has granted orphan drug designation to its lead program, QXL138AM, for the treatment of multiple myeloma.
[Nammi Therapeutics, Inc. (Cision US Inc.)] |
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| bluebird bio, Inc. announced the outcome of the FDA Cellular, Tissue, and Gene Therapies Advisory Committee discussion of betibeglogene autotemcel (beti-cel) for the treatment of people with beta-thalassemia who require regular red blood cell transfusions.
[bluebird bio, Inc.] |
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| Centogene N.V. announced that it has expanded its long-standing PYRUKYND® partnership with Agios Pharmaceuticals, Inc. Agios’ PYRUKYND® is a selective, small molecule activator of the pyruvate kinase enzyme.
[Centogene N.V.] |
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| October 3 – 5
Vancouver, British Columbia, Canada |
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| | American Association for Cancer Research – Various, United States |
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| | Francis Crick Institute – London, England, United Kingdom |
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| | Albert Einstein College of Medicine – New York, New York, United States |
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| | Van Andel Institute – Grand Rapids, Michigan, United States |
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| | Columbia University – New York, New York, United States |
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