 | | Vol. 13.35 – 6 September, 2022 |
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| The authors showed that OX40 was upregulated on T cells infiltrating graft-versus-host disease (GvHD) target organs in a rhesus macaque model, supporting the hypothesis that targeted ablation of OX40+ T cells will mitigate GvHD pathogenesis.
[Blood] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists performed RNA sequencing, methylation array analysis, whole exome, and targeted deep sequencing on 84 infants with KMT2A-rearranged leukemia.
[Nature Communications] |
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| Researchers generated an activation-induced cytidine deaminase (AID) knockout chronic lymphocytic leukemia (CLL) mouse model and found that these mice died significantly earlier than their AID-proficient counterparts.
[Leukemia] |
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| Scientists identified human B-plasmacytoid dendritic cells bifurcation as large fluctuating transcriptome dynamics in the putative B/NK progenitor region by dry and wet methods.
[Cell Reports] |
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| Transport assays in isolated membrane vesicles showed a concentrationdependent inhibition of multidrug resistance protein 4 (MRP4)-mediated transport of cyclic nucleotides, thromboxane B2 and fluorescein (FITC)- labeled sphingosine-1-phosphate by the selective MRP4 inhibitor Ceefourin-1.
[Haematologica] |
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| Using deep, error-corrected, targeted DNA sequencing researchers assayed for somatic mutations in clonal hematopoiesis-driver genes in peripheral blood mononuclear cells isolated from de-identified blood samples collected from 14 astronauts who flew Shuttle missions between 1998–2001.
[Communications Biology] |
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| Whole-brain cerebral blood flow and oxygen extraction fraction were measured by MRI one to three months before and 12-24 months after HSC transplant in ten children with sickle cell disease: three with prior overt strokes, five with prior silent strokes, and one with abnormal transcranial Doppler ultrasound velocities.
[Blood] |
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| The authors found that the Hippo pathway coactivator TAZ was potently induced in old HSCs and protected these cells from functional decline.
[Nature Communications] |
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| Researchers investigated the combination of IKZF1del and CD20 immunotypes in adult patients with B cell acute lymphoblastic leukemia in the PDT-ALL-2016 cohort.
[Bone Marrow Transplantation] |
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| Scientists compared the outcomes of 52 peripheral T cell lymphoma patients treated with two different treatment regimens followed by autologous stem cell transplantation at their center between 2012 and 2021.
[Scientific Reports] |
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| Investigators provide an up-to-date review of clonal hematopoiesis within the context somatic mosaicism and aging and describe recent epidemiological studies which have reported associations with age-related disease.
[Physiological Reviews] |
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| Hypoxia-inducible factor-prolyl hydroxylase inhibitors (HIF-PHIs) are novel agents to treat anemia in CKD. They stimulate endogenous erythropoietin production via HIF activation and thereby induce erythropoiesis.
[Pharmacology & Therapeutics] |
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| Curis has received another spark of hope as the FDA lets the biotech resume enrollment for a part of its Phase I/II study assessing emavusertib in patients with leukemia.
[Fierce Biotech] |
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| January 29 – February 2, 2023
Banff, Alberta, Canada |
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| | Sandoz International GmbH – United Counties of Prescott and Russell, Ontario, Canada |
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| | STEMCELL Technologies, Inc. – Vancouver, British Columbia, Canada |
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| | University of Wisconsin-Madison – Madison, Wisconsin, United States |
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| | St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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| | The University of Chicago – Chicago, Illinois, United States |
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