Hematopoiesis News Volume 13.40 | Oct 11 2022

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    Jamie Kang
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    2022-10-11 | HN 13.40


    Hematopoiesis News by STEMCELL Technologies
    Vol. 13.40 – 11 October, 2022
    TOP STORY

    Deciphering Transcriptome Alterations in Bone Marrow Hematopoiesis at Single-Cell Resolution in Immune Thrombocytopenia

    Researchers explored defective hematopoiesis and provided novel insights regarding the pathogenesis of immune thrombocytopenia using bone marrow CD34+ hematopoietic stem and progenitor cells.
    [Signal Transduction and Targeted Therapy]

    Full Article
    Image of erythroblasts which were simply & efficiently generated from PSCs using the STEMdiff Erythroid Kit.
    PUBLICATIONSRanked by the impact factor of the journal

    Iron Regulatory Protein (IRP)–Mediated Iron Homeostasis Is Critical for Neutrophil Development and Differentiation in the Bone Marrow

    Scientists reported that global disruption of both IRP1 and IRP2 in adult mice impaired neutrophil development and differentiation in the bone marrow, yielding immature neutrophils with abnormally high glycolytic and autophagic activity, resulting in neutropenia.
    [Science Advances]

    Full Article

    IFITM3 Regulates Fibrinogen Endocytosis and Platelet Reactivity in Non-Viral Sepsis

    Non-viral sepsis upregulated IFITM3, an interferon-responsive gene that restricts viral replication. Since it was found linked to clathrin-mediated endocytosis, researchers examined if IFITM3 promoted endocytosis of alpha granule proteins.
    [Journal of Clinical Investigation]

    AbstractFull ArticleGraphical Abstract

    Loss of Ribonuclease DIS3 Hampers Genome Integrity in Myeloma by Disrupting DNA:RNA Hybrid Metabolism

    By exploiting the TCGA dataset, scientists found that DIS3 played a prominent role in the DNA damage response where inactivation in myeloma drove tumorigenesis via DNA:RNA hybrid-dependent enhanced genome instability and increased mutational rate.
    [EMBO Journal]

    Full ArticleGraphical Abstract

    The Inner Nuclear Membrane Protein NEMP1 Supports Nuclear Envelope Openings and Enucleation of Erythroblasts

    Researchers presented that Nemp1 knockout mice showed peripheral blood defects, anemia in neonates, ineffective erythropoiesis, splenomegaly, and stress erythropoiesis.
    [PLoS Biology]

    Full Article

    Identifying a Novel Role for the Master Regulator Tal1 in the Endothelial to Hematopoietic Transition

    Scientists investigated the function of Tal1 and its binding partners using a mouse embryonic stem cell-based differentiation system to model hematopoietic development and hematopoietic stem and progenitor cell generation.
    [Scientific Reports]

    Full Article

    Oral HDAC Inhibitor Tucidinostat in Patients with Relapsed or Refractory Peripheral T-Cell Lymphoma: Phase IIb Results

    This multicenter Phase IIb study aimed to investigate the efficacy and safety of tucidinostat, 40 mg twice per week, in patients with relapsed/refractory peripheral T cell lymphoma.
    [Haematologica]

    Abstract

    AML-484 First Results of a Phase II Study (STIMULUS-AML1) Investigating Sabatolimab + Azacitidine + Venetoclax in Patients with Newly Diagnosed Acute Myeloid Leukemia (ND AML)

    Scientists reported findings from the dose-escalation part of STIMULUS-AML1 treatment with sabatolimab+venetoclax+azacitidine to test whether it improved ND-AML patient outcomes in comparison to Phase Ib responses with sabatolimab+hypomethylating agent treatment.
    [Clinical Lymphoma Myeloma & Leukemia]

    Abstract
    ON1058PSC-ISSCR Innovation Showcase Webinars Set 1_final 300 x 250 A
    REVIEWS

    TP53-Mutated Myelodysplastic Syndrome and Acute Myeloid Leukemia: Biology, Current Therapy, and Future Directions

    Investigators discuss recent insights into the biology of TP53-mutated myelodysplastic syndrome and AML, current treatments, and emerging therapies, including immunotherapeutic and nonimmune-based approaches for this entity.
    [Cancer Discovery]

    Abstract

    Role of TET Dioxygenases in the Regulation of Both Normal and Pathological Hematopoiesis

    The authors summarize recent research on 10-11 translation dioxygenases (TETs) in regulating both normal and pathogenic hematopoiesis, as well as the concomitant mutations and aberrant signals in TET2-mutant malignancies.
    [Journal of Experimental & Clinical Cancer Research]

    Full Article
    INDUSTRY AND POLICY NEWS

    Bone Marrow Transplant and Cell Therapies Unit at Tampa General Brings More Treatment Options

    Tampa General Hospital Cancer Institute established an adult Bone Marrow Transplant and Cell Therapies unit that focused on treating patients with aggressive blood cancers such as leukemias, lymphomas, multiple myeloma as well as other cancers.
    [Tampa General Hospital]

    Press Release

    Mustang Bio Announces First Patient Treated in Its Multicenter Phase I/II Clinical Trial of MB-106, a First-in-Class CD20-Targeted, Autologous CAR T Cell Therapy to Treat B-cell Non-Hodgkin Lymphoma and Chronic Lymphocytic Leukemia

    Mustang Bio, Inc. announced its first patient to be treated in its Phase I/II clinical trial evaluating the safety and efficacy of MB-106, their first-in-class CD20-targeted, autologous chimeric antigen receptor T (CAR T) cell therapy for relapsed or refractory B-cell non-Hodgkin lymphomas and chronic lymphocytic leukemia.
    [Mustang Bio, Inc.]

    Press Release
    FEATURED EVENT

    Cell Symposia: Multifaceted Mitochondria

    November 6 – 8, 2022
    Seville, Spain

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Associate – Immunobiology of Blood Diseases

    Baylor College of Medicine – Houston, Texas, United States

    Postdoctoral Fellow – Immunothrombosis

    Blood Centre of Wisconsin – Milwaukee, Wisconsin, United States

    Postdoctoral Fellow – Leukemia, Ovarian, Colorectal, and Lung Cancer

    CancerCare Manitoba Research Institute – Winnipeg, Manitoba, Canada

    Postdoctoral Associate – Chromosomal Architecture

    University of Miami – Miami, Florida, United States

    Postdoctoral Associate – Hematopoietic Stem Cells

    Baylor College of Medicine – Houston, Texas, United States

    > See All Jobs

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