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| The authors assessed the roles of gut microbial DNA-containing extracellular vesicles in regulating liver cellular abnormalities in the course of nonalcoholic fatty liver diseases and nonalcoholic steatohepatitis.
[Acta Physiologica] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers found that the expression levels of Sptlc1 and Sptlc2, the major serine palmitoyltransferase subunits, were upregulated and that the cellular concentrations of ceramide and dihydroceramide were elevated by acute endoplasmic reticulum stress inducers in primary hepatocytes and HepG2 cells.
[Experimental and Molecular Medicine] |
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| The loss of PRMT5 led to hyper-accumulation of P21 and endoreplication-dependent formation of pathological mono-nuclear polyploid hepatocytes. PRMT5 and symmetric dimethylation at histone H4 arginine 3 were directly associated with chromatin of P21 to suppress its transcription.
[Journal of Genetics and Genomics] |
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| Researchers found that vascular endothelial growth factor A elevation was considerably distributed in hepatocytes of clinical and murine NAFLD-HCC specimens.
[Acta Pharmacologica Sinica] |
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| Investigators suggested that ASPP2 promoted BRAF/MEK/ERK signal activation by promoting the formation of an ASPP2/k18/14-3-3 ternary complex via the RDIVpSGP motif at the N terminus.
[Cancer Gene Therapy] |
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| By examining changes in the transcriptome and the methylome using an in vitro hepatocyte differentiation model, the authors showed putative DNA methylation-regulating transcription factors, which were likely involved in DNA demethylation and maintenance of hypo-methylation in a differentiation stage-specific manner.
[Communications Biology] |
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| Scientists investigated the cytotoxic potential of three apigeninidin-rich extracts of Sorghum bicolor against selected cancer cell lines and their ameliorative effect on aflatoxin B1-mediated hepatorenal derangements in rats.
[Scientific Reports] |
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| Nuclei were extracted from livers of adult male and female mice, from males infused with GH continuously, mimicking the female plasma GH pattern, and from mice exposed to TCPOBOP, a xenobiotic agonist ligand of the nuclear receptor CAR that perturbs sex-biased gene expression.
[Endocrinology] |
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| Researchers evaluated the influence of cisplatin-sunitinib combination on HepG2 cells regarding their cytotoxicity and implicated intracellular pathways.
[Life Sciences] |
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| The authors comprehensively examined the hepatic and extrahepatic stereoselective metabolism of BUP in vitro.
[Drug Metabolism and Disposition] |
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| Scientists provided an overview of contemporary diagnostic principles of portal hypertension and indications for measuring portal pressure in cirrhosis.
[Scandinavian Journal of Gastroenterology] |
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| Arrowhead Pharmaceuticals Inc. announced that it has dosed the first patients in the Phase II GATEWAY clinical study of investigational ARO-ANG3 for the treatment of patients with homozygous familial hypercholesterolemia.
[Arrowhead Pharmaceuticals Inc.] |
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| June 14 – 18, 2021
Virtual |
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| University of Gothenburg – Gothenburg, Sweden |
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| National Institute for Health and Medical Research – Strasbourg, France |
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| | Baylor College of Medicine – Houston, Texas, United States |
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| | Johns Hopkins University – Baltimore, Maryland, United States |
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| | The University of British Columbia – Vancouver, British Columbia, Canada |
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