 | | Vol. 6.26 – 22 July, 2022 |
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| Scientists investigated how β-arrestin1 modulated hepatocyte and hepatic stellate cell activation during liver fibrosis.
[Hepatology] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Poly(beta-amino-ester) nanoparticles were used to deliver a completely CpG-free plasmid harboring mutant herpes simplex virus type 1 sr39 thymidine kinase DNA to human HCC cells.
[Science Advances] |
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| Researchers conducted a series of Ncoa4 gain- and loss-of-function experiments to examine how ferritinophagy affected lipid metabolism through phenotypic and lipidomic analyses both in vitro and in vivo.
[Hepatology Communications] |
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| Investigators found that expression of hepatic tumor necrosis factor-like weak inducer of apoptosis (TWEAK) and its receptor tumor necrosis factor receptor superfamily member 12A (Tnfrsf12a) were significantly increased during acute liver failure induced by thioacetamide or acetaminophen.
[Cell Death Discovery] |
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| Scientists investigated the role of RNF31 and RBCK1 in HCC and showed that RNF31 and RBCK1 were overexpressed in HCC and that upregulation of RNF31 and RBCK1 indicated poor clinical outcomes in patients with HCC.
[Cell Death Discovery] |
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| The authors investigated a novel mechanism by which wogonoside mitigated liver fibrosis by inducing ferroptosis in hepatic stellate cells.
[Phytotherapy Research] |
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| Investigators extended a previously published multiscale model of vascular tumor growth, and integrated it with an experimentally verified network of central metabolism in HEPG2 cells.
[Scientific Reports] |
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| Researchers investigated the functional role of high-mobility group box 2 (HMGB2), a chromatin protein in liver regeneration using wild-type and HMGB2-knockout mice.
[Scientific Reports] |
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| To test whether signaling lymphocytic activation molecule 1 (SLAMF1) was expressed by hepatocytes, scientists treated HepG2 cells and primary murine hepatocytes with palmitic acid to induce a state of lipotoxicity mimicking non-alcoholic steatohepatitis.
[American Journal of Physiology-Gastrointestinal and Liver Physiology] |
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| The authors investigated whether endoplasmic reticulum stress played a role in nonesterified fatty acid-induced hepatic insulin resistance in dairy cows.
[Journal of Dairy Science] |
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| Researchers designed a novel hepatocyte scaffold based on porcine liver extracellular matrix and chitosan fabrics.
[Journal of Biomaterials Applications] |
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| The authors discuss the putative metabolic mechanisms underlying the emergence of non-alcoholic fatty liver disease (NAFLD) or non-alcoholic steatohepatitis (NASH) after liver transplantation as well as optimal therapeutic approaches for recipients of liver transplants.
[Nature Reviews Endocrinology] |
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| Vertex Pharmaceuticals is getting deeper into in vivo gene editing. Months after partnering with Mammoth Biosciences, the storied biotech is back with another deal, ponying up $60 million to work with Verve Therapeutics on a single undisclosed liver disease.
[Fierce Biotech] |
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| October 20 – 21, 2022
Turin, Italy |
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| | Virginia Commonwealth University – Richmond, Virginia, United States |
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| | University of North Carolina at Greensboro – Kannapolis, North Carolina, United States |
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| | Foundation for Liver Research – London, England, United Kingdom |
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| | The Chinese University of Hong Kong – Hong Kong, China |
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| | Pennsylvania State University – State College, Pennsylvania, United States |
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