 | | Vol. 10.23 – 14 June, 2022 |
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| Investigators demonstrated that sex-related differences in tumor burden depended on adaptive immunity.
[Immunity] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The authors indicated that cavin-4 IgG may be the first specific serological autoantibody biomarker identified in immune-mediated rippling muscle disease.
[JAMA Neurology] |
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| Scientists demonstrated that targeted inhibition of lysine-specific demethylase 1 (LSD1) in small cell lung cancer restored major histocompatibility complex (MHC) class I cell surface expression and transcriptionally activated genes encoding the antigen presentation pathway.
[Journal of Thoracic Oncology] |
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| Researchers presented 101,326 single-cell transcriptomes and surface protein landscape from the infusion products of 12 acute lymphocytic leukemia (ALL) patients.
[Science Advances] |
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| Investigators showed that in non-small cell lung cancer patients, a deficient regulatory B cell checkpoint failed to limit self-reactive T cell enhanced activity and auto-antibody formation enabled by PD-1/PD-L1 blockade, leading to severe auto-inflammatory sequelae.
[Nature Communications] |
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| Scientists reported that in human monocytes/macrophages, CXCL4 initiated signaling cascades and downstream epigenomic reprogramming that changed the profile of the Toll-like receptor (TLR) 8 response by selectively amplifying inflammatory gene transcription and interleukin−1β production.
[Nature Communications] |
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| This first-in-human study evaluated MOXR0916, a humanized effector-competent agonist IgG1 monoclonal anti-OX40 antibody.
[Clinical Cancer Research] |
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| Researchers showed that arming cytokine-induced memory-like NK cells with a neoepitope-specific CAR significantly enhanced their antitumor responses to nucleophosphmin-1 (NPM1)-mutated acute myeloid leukemia while avoiding off-target toxicity.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| The authors discovered a potential pathogenetic role of ferroptosis, an iron-dependent regulated cell death mechanism, in multiple sclerosis.
[Cellular & Molecular Immunology] |
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| Researchers applied genetic association analysis on >200 immune cell traits and >100 cytokine production profiles in response to stimuli measured to identify genetic determinants of immune function, and compared the results obtained in type 1 diabetes to healthy controls.
[eLife] |
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| Scientists explored the relationship between IKZF2 and lupus nephritis based on multi-omics data. They carried out a meta-analysis of publicly available data, including not only tubulointerstitium, but also glomerulus tissue samples from lupus nephritis patients and controls.
[Scientific Reports] |
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| The correlations between CD47 expression and immune cell infiltration, stromal components, immune checkpoint genes, tumor mutational burden, and microsatellite instability were analyzed from a public database.
[Scientific Reports] |
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| The authors discuss why defining adaptive immune resistance mechanisms at the tumour site should be a key focus to direct future drug development as well as practical approaches to improve current cancer therapy.
[Nature Reviews Drug Discovery] |
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| Scientists highlight key features of monocyte and macrophage biology that are being explored as potential targets for cancer therapies and what aspects of myeloid cells need a deeper understanding to identify rational combinatorial strategies to improve clinical outcomes of patients with cancer.
[Nature Reviews Immunology] |
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| Investigators provide an overview of selected emerging therapies that predominantly target processes within the central nervous system (CNS) that are thought to be involved in limiting non-relapsing, progressive disease injury or promoting tissue repair.
[Nature Reviews Neurology] |
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| Umoja Biopharma, Inc. and TreeFrog Therapeutics announced that they have entered into a collaboration to evaluate Umoja’s iPSC platform within TreeFrog’s C-Stem™ technology for scalable expansion and immune cell differentiation in bioreactors.
[Umoja Biopharma, Inc.] |
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| The FDA approved an Eli Lilly drug that is the first-ever treatment for alopecia areata, an autoimmune disorder that triggers sudden hair loss.
[STAT News] |
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| CureVac, bruised from its COVID-19 vaccine woes, has struck another deal to bolster its cancer vaccine development capabilities, buying Frame Cancer Therapeutics for its ability to identify unique and shared neoantigens.
[Fierce Biotech] |
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| September 7 -11, 2022
Woods Hole, Massachusetts, United States |
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| | New York Blood Center – New York, New York, United States |
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| | University of North Dakota – Grand Forks, North Dakota, United States |
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| | University of Pittsburgh School of Medicine – Pittsburgh, Pennsylvania, United States |
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| | Temple University – Philadelphia, Pennsylvania, United States |
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| | China Medical University – Shenyang, China |
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