 | | Vol. 14.21 – 10 June, 2022 |
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| Investigators designed chimeric receptors that had an orthogonal IL-2 receptor extracellular domain fused with the intracellular domain of receptors for common γ-chain cytokines IL-4, IL-7, IL-9, and IL-21 such that the orthogonal IL-2 cytokine elicited the corresponding γc cytokine signal.
[Nature] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists examined cell type-specific roles of the pH sensor G protein-coupled receptor 65 and its inflammatory disease-associated Ile231Leu-coding variant in inflammation control.
[Nature Immunology] |
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| Researchers reported the development and applicability of libraries of immune cells displaying diverse repertoires of chimeric antigen receptors that could recognize non-self antigens and display antigen-dependent clonal expansion.
[Nature Biomedical Engineering] |
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| Scientists reported that autoimmune hepatitis (AIH)-like disease development is dependent on both IFNγ and AhR signaling, as blocking either reverts ongoing AIH-like pathology.
[Cell Host & Microbe] |
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| The authors developed a combinatorial approach where a Toll-like receptor 9 agonist and Fc-fused IL-12 protein were injected together into just one of several tumor sites in a mouse.
[Science Immunology] |
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| Researchers assessed the impact of cytotoxic T cells on the local lymphatic vasculature and concomitant tumor dissemination during an antitumor response.
[Science Advances] |
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| The authors showed that mouse and human liver-resident αGalCer/CD1d-binding invariant natural killer T cells largely corresponded to a novel Zbtb16+Tbx21+Gata3+MaflowRorc– subset that exhibited profound transcriptional, phenotypic, and functional plasticity.
[Nature Communications] |
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| Scientists created novel therapeutics using transmembrane stem cell factor (tmSCF) embedded in proteoliposomes or lipid nanodiscs. Mouse models of anaphylaxis and ischemia revealed the tmSCF-based therapies did not activate mast cells and improved the revascularization in the ischemic hind limb.
[Nature Communications] |
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| When analyzing the distribution of Treg cells in experimental autoimmune encephalomyelitis mice, the aged mice exhibited a higher proportion of polyclonal (pan-) peripheral Treg (pTreg) cells and a lower proportion of antigen-specific pTreg cells in the periphery but lower proportions of both pan- and antigen-specific Treg cells in the central nervous system.
[Aging Cell] |
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| The authors showed that Aire regulated the suppressive signature of recirculating Treg independently of the remodeling of the medullary 3D organization throughout life where Treg resided.
[Cellular and Molecular Life Sciences] |
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| Investigators found that mitochondrial reactive oxygen species were required for IL-12 plus IL-18-driven production of IFN-γ, an essential cytokine for inflammatory and autoimmune disease development.
[Cell Death & Disease] |
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| Researchers examined the impact of β-glucan-induced innate immune training on monocytes from aging healthy humans as well as sepsis patients.
[Frontiers in Immunology] |
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| The authors administered approximately 20 million replication-incompetent VSV-G lentiviral particles carrying an anti-CD19CAR-2A-GFP transgene comprising either an FMC63 or 1D3 anti-CD19 binding domain, or a GFP-only control transgene, to wild-type C57BL/6 mice by tail vein infusion.
[Molecular Therapy-Methods & Clinical Development] |
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| Scientists highlight non-canonical targets in preclinical multiple sclerosis research with a focus on five highly promising areas: oligodendrocytes, the blood–brain barrier, metabolites and cellular metabolism, the coagulation system, and tolerance induction.
[Nature Reviews Drug Discovery] |
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| The authors discuss how distinct functions of synovial tissue macrophage (STM) clusters shape the synovial tissue environment in health, during inflammation, and in disease remission, as well as how an increased understanding of STM heterogeneity might aid the prediction of clinical outcomes.
[Nature Reviews Rheumatology] |
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| Investigators provide a global overview of the circadian immune system, focusing on recent advances in the rapidly expanding field of circadian immunology.
[Science Immunology] |
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| Umoja Biopharma, Inc. and TreeFrog Therapeutics announced that they have entered into a collaboration to evaluate Umoja’s induced pluripotent stem cell platform within TreeFrog’s C-Stem™ technology for scalable expansion and immune cell differentiation in bioreactors.
[Umoja Biopharma, Inc.] |
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| October 3 – 5, 2022
Vancouver, British Columbia, Canada |
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| | Temple University – Philadelphia, Pennsylvania, United States |
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| | Human Technopole – Milan, Italy |
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| | Van Andel Institute – Grand Rapids, Michigan, United States |
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| | Albert Einstein College of Medicine – New York, New York, United States |
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| | China Medical University – Shenyang, China |
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