Immune Regulation News Volume 14.27 | Jul 19 2022

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    2022-07-29 | IRN 14.27


    Immune Regulation News by STEMCELL Technologies
    Vol. 14.27 – 29 July, 2022
    TOP STORY

    Tcf1–CTCF Cooperativity Shapes Genomic Architecture to Promote CD8+ T Cell Homeostasis

    Investigators showed that transcription factors Tcf1 and Lef1 were intrinsically required for homeostatic proliferation of CD8+ T cells.
    [Nature Immunology]

    Full Articles
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    Runx3 Drives a CD8+ T Cell Tissue Residency Program That Is Absent in CD4+ T Cells

    The authors showed that, as a direct consequence of this Runx3-deficiency, CD4+ tissue-resident memory T cells (TRM) cells lacked the transforming growth factor-β-responsive transcriptional network that underpins the tissue residency of epithelial CD8+ TRM cells.
    [Nature Immunology]

    AbstractPress Release

    Lymph Node Homeostasis and Adaptation to Immune Challenge Resolved by Fibroblast Network Mechanics

    Scientists found that in murine models of immune challenge, cytoskeletal mechanics of a cellular meshwork of fibroblasts determinedd tissue tension independently of ECM scaffolds.
    [Nature Immunology]

    Full Article

    SMAD4, Activated by the TCR-Triggered MEK/ERK Signaling Pathway, Critically Regulates CD8+ T Cell Cytotoxic Function

    Researchers found that SMAD4 was critical in promoting CD8+ T cell function in both tumor and infection models.
    [Science Advances]

    Full Article

    An Acquired Phosphatidylinositol 4-Phosphate Transport Initiates T Cell Deterioration and Leukemogenesis

    Investigators reported that oxysterol-binding protein-related protein 4 L was expressed in adult T-cell leukemia cells but not normal T cells.
    [Nature Communications]

    Full Article

    Transcription Factor EB Coordinates Environmental Cues to Regulate T Regulatory Cells’ Mitochondrial Fitness and Function

    The authors identified that transcription factor EB was induced by host nutrition deprivation or interleukin (IL)-2 in CD4+ T cells.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Abstract

    An Integrin Axis Induces IFN-β Production in Plasmacytoid Dendritic Cells

    The SLAYGLR-mediated α4 integrin/IFN-β axis is MyD88 independent and operated via a PI3K/mTOR/IRF3 pathway.
    [Journal of Cell Biology]

    Abstract

    The Interaction between STING and NCOA4 Exacerbates Lethal Sepsis by Orchestrating Ferroptosis and Inflammatory Responses in Macrophages

    Scientists demonstrated that STING promotes sepsis-induced multiple organ injury by inducing macrophage ferroptosis in a cGAS- and interferon-independent manner.
    [Cell Death & Disease]

    Full Article

    Deficiency of Mature B Cells Does Not Alter the Atherogenic Response to Castration in Male Mice

    Researchers studied B cell-deficient μMT and genotype control male mice on an atherosclerosis-prone Apoe−/− background that were castrated or sham-operated pre-pubertally and fed a high-fat diet between 8 and 16 weeks of age to accelerate atherosclerosis development.
    [Scientific Reports]

    Full Article

    Learn about immunological considerations for hPSC banking by watching Dr. David Turner's webinar from the Nature Research Round Table on hPSC Quality
    REVIEWS

    Activation and Regulation of Alloreactive T Cell Immunity in Solid Organ Transplantation

    Transplantation is the only curative treatment for patients with kidney failure but it poses unique immunological challenges that must be overcome to prevent allograft rejection and ensure long-term graft survival.
    [Nature Reviews Nephrology]

    Abstract
    INDUSTRY AND POLICY NEWS

    Takeda Announces Positive Topline Results from Pivotal Phase III Clinical Trial Evaluating HYQVIA® for Maintenance Treatment of Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP)

    Takeda announced that ADVANCE-1, a randomized, placebo-controlled, double-blind Phase III clinical trial evaluating HYQVIA® for the maintenance treatment of chronic inflammatory demyelinating polyradiculoneuropath, met its primary endpoint.
    [Takeda]

    Press Release

    Akari Therapeutics Announces Positive Results from Recent Pre-Clinical Studies of Investigational PASylated® Nomacopan That Support the Potential to Advance Research Toward IND/IMPD for Clinical Trials in Geographic Atrophy

    Akari Therapeutics, Plc announced positive results from recent pre-clinical studies on the tolerability and extended dose interval of long-acting PAS-nomacopan in development for geographic atrophy in dry age-related macular degeneration.
    [Akari Therapeutics, Plc]

    Press Release
    FEATURED EVENT

    5th International Cancer Symposium

    November 2 – 4, 2022
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    JOB OPPORTUNITIES

    Research Associate – Pluripotent Stem Cells

    The University of British Columbia – Vancouver, British Columbia, Canada

    Research Scientist – Inflammation

    Gilead Sciences, Inc. – Foster City, California, United States

    Scientist – PET Imaging

    University Hospital of North Norway – Tromsø, Norway

    Postdoctoral Scientists – Pluripotent Stem Cells and Developmental Biology

    Weill Cornell Medical College – New York, New York, United States

    Principal Scientist – Cancer Immunology Drug Discovery

    Boehringer Ingelheim – Vienna, Austria

    > See All Jobs

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