 | | Vol. 14.32 – 2 September, 2022 |
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| Microbiota-induced Th17 cells afforded protection by regulating lipid absorption across intestinal epithelium in an IL-17-dependent manner.
[Cell] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| It is currently accepted that cancer-associated fibroblasts participate in T cell exclusion from tumor nests. To unbiasedly test this, researchers used single-cell RNA sequencing coupled with multiplex imaging on a large cohort of lung tumors.
[Cancer Discovery] |
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| Scientists showed that the gut IEL GLP-1 receptor (GLP-1R) was not required for enteroendocrine L cell GLP-1 secretion and glucose homeostasis nor for the metabolic benefits of GLP-1R agonists
[Cell Metabolism] |
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| The authors examined the heterogeneity of CD8+ T cells in tumors, metastatic lymph nodes, and peripheral blood from patients with early breast cancer.
[Science Immunology] |
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| Investigators presented the global metabolome in six peripheral tissues from 13 maternal immune activation and 10 control offspring that were confirmed to display atypical neurodevelopment, elevated immune profiles, and neuropathology.
[Molecular Psychiatry] |
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| Researchers showed that PD-L2 deficiency prevented the induction of tolerance to ovalbumin and control of airway hyperreactivity, in particular by limiting periphery from naive Treg numbers and function.
[Nature Communications] |
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| BATF directly bound to the cis-regulatory elements of type 1 effector genes, restrained their chromatin accessibility, and inhibited their expression.
[Journal of Experimental Medicine] |
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| The authors showed that in murine dendritic cells the lysosomal histidine/peptide solute carrier transporter SLC15A4, associated with human inflammatory disorders, was recruited to phagosomes and was required for optimal inflammasome activity after infectious or sterile stimuli.
[EMBO Journal] |
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| Scientists investigated whether innate immune inflammasome complexes, comprising the adaptor ASC, Caspase-1 and specific pattern recognition receptors, promoted the pathogenesis of emphysema.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Investigators generated a unique murine model named ARE-Del, with chronic overexpression of IFNγ, by altering IFNγ metabolism. These mice developed an immunologic and clinical profile similar to patients with primary biliary cholangitis, including high titers of autoantibodies and portal inflammation.
[Cellular & Molecular Immunology] |
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| It was released from neutrophils, microglia, and endothelial cells throughout disease; its interaction with T cells potentiates Th17 differentiation in lymph nodes and Th17 to exTh17 plasticity and IFN-γ production in the spinal cord.
[PLoS Biology] |
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| Investigators review both some facts about human tumor-specific or tumor-associated antigens, as well as some hopes for their future use in cancer immunotherapy.
[Clinical Cancer Research] |
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| Scientists discuss major candidate molecules for Treg-targeted therapeutic strategies in breast cancers, detailing the pros and cons of various approaches including monoclonal antibody-mediated depletion, homeostasis destabilization, and functional blockade.
[Cancer Research] |
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| The authors highlight the role of the developmental origin, the link between the wound phase-specific activation state and metabolic reprogramming as well as the fate of macrophages during the resolution of the wounding response.
[Cold Spring Harbor Perspectives in Biology] |
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| Hadlima, developed by South Korea-based biotech firm Samsung Bioepis and to be commercialized by global healthcare company Organon, became the latest medication to gain the approval of the FDA for the treatment of several disorders, including arthritis, ulcerative colitis, and plaque psoriasis.
[Humira (Medical News Today)] |
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| September 19 – 20, 2022
Vejle, Denmark |
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| | Melanoma Institute Australia – Sydney, Australia |
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| | STEMCELL Technologies, Inc. – Vancouver, British Columbia, Canada |
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| | University of Michigan – Ann Arbor, Michigan, United States |
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| | University of Cologne – Cologne, Germany |
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| | The University of Chicago – Chicago, Illinois, United States |
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