 | | Vol. 14.34 – 16 September, 2022 |
| |
|
|
| The authors investigated the cells and molecular components required for induced Treg cell differentiation. They found that antigen presentation by cells expressing RORγt, rather than by classical dendritic cells, was required and sufficient for induction of Treg cells.
[Nature] |
|  |
|
|
| PUBLICATIONSRanked by the impact factor of the journal |
|
|
|
| Scientists showed that some T cells elongated telomeres by acquiring telomere vesicles from antigen-presenting cells independently of telomerase action.
[Nature Cell Biology] |
|
|
|
| Adoptive transfer experiments showed that tissue-resident T helper (Trh) cells from graft-versus-host-disease (GVHD) target tissues gave rise to peripheral T helper (Tph) cells in the blood, and conversely, Tph cells from the blood gave rise to Trh cells in GVHD target tissues.
[Blood] |
|
|
|
| Researchers engineered a mouse named L15R that expressed IL-15R in hepatic stellate cells at normal levels, but not in other liver cells.
[Hepatology] |
|
|
|
| Scientists investigated the effect of homoarginine supplementation on atherosclerotic plaque development with a particular focus on inflammation.
[Circulation Research] |
|
|
|
| Utilizing mice with IL-27 p28 deficiency in dendritic cells, investigators demonstrated that IL-27 p28 deficiency resulted in impaired Treg cell function and enhanced effector T cell responses, corresponding to aggravated acute graft-versus-host disease in mice.
[Signal Transduction and Targeted Therapy] |
|
|
|
| The authors created a transgenic mouse model to enable direct mapping of the proteinaceous content of autophagosomes in primary cells by LC3 proximity labeling.
[Nature Communications] |
|
|
|
| Quantitative analyses of CD4+ T cell subsets and of CD8+ T cells in the labial salivary glands from untreated patients with primary Sjögren’s syndrome revealed that activated CD8+ cytotoxic T cells were the most prominent T cells in these infiltrates.
[Scientific Reports] |
|
|
|
| Researchers investigated the possible protective effect of escin, the active constituent of a natural mixture of triterpene saponin glycoside, against immune-mediated hepatitis driven by concanavalin A and elucidated its possible underlying mechanisms.
[Inflammopharmacology] |
|  |
|
|
|
| Scientists review the sometimes-dichotomous roles played by immune cells during neurodegenerative diseases and explore how brain trauma can serve as a disease initiator or accelerant.
[Trends in Neurosciences] |
|
|
|
| Trained immunity has been implicated in helminth-driven immune regulation and allergen-specific immunotherapy, suggesting its exploitation in future therapies.
[Mucosal Immunology] |
|
|
|
|
| | Horizon Therapeutics plc announced that its Phase II trial evaluating dazodalibep for the treatment of Sjögren’s syndrome met the primary endpoint in patients with moderate-to-high systemic disease activity as defined by the European Alliance of Associations for Rheumatology. |
|
|
|
|
| September 27 – 29, 2022
Leuven, Belgium |
|
|
|
|
|
| | Celsius Therapeutics – Cambridge, Massachusetts, United States |
|
|
|
| | Michigan State University – East Lansing, Michigan, United States |
|
|
|
| | Louisiana State University – Baton Rouge, Louisiana, United States |
|
|
|
| | STEMCELL Technologies, Inc. – Vancouver, British Columbia, Canada |
|
|
|
| | Melanoma Institute Australia – Sydney, Australia |
|
|
|
|
Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
