 | | Vol. 10.29 – 27 July, 2022 |
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| Researchers identified CPL1 as an effector protein secreted by Cryptococcus neoformans that drove alternative activation of macrophages to enable pulmonary infection in mice.
[Nature] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators evaluated the safety and preliminary efficacy of OP-101, a hydroxyl-polyamidoamine dendrimer–N-acetylcysteine conjugate that specifically targeted activated macrophages, in patients with severe COVID-19.
[Science Translational Medicine] |
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| To provide additional therapies against Omicron, the authors isolated a monoclonal antibody named P2G3 from a previously infected vaccinated donor and showed that it had picomolar-range neutralizing activity against Omicron BA.1, BA.1.1, BA.2, and all other variants tested.
[Nature Microbiology] |
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| Scientists demonstrated that SARS-CoV-2 nucleocapsid protein could interact with Smad3, which downregulated cystic fibrosis transmembrane conductance regulator expression via microRNA-145.
[Signal Transduction and Targeted Therapy] |
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| The authors reported that human neuronal cells, nonpermissive to infection through the endocytic pathway, could be infected when cocultured with permissive infected epithelial cells. SARS-CoV-2 induced the formation of tunneling nanotubes and exploited this route to spread to uninfected cells.
[Science Advances] |
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| Scientists described a chemically engineered nanosystem encapsulating CRISPR–Cas13d, developed to specifically target lung protease cathepsin L (Ctsl) messenger RNA to block SARS-CoV-2 infection in mice.
[Nature Chemical Biology] |
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| Researchers compared the potency of 17 different human interferons against multiple viral lineages sampled during the course of the global outbreak, including ancestral and five major variants of concern that include the B.1.1.7, B.1.351, P.1, B.1.617.2, and B.1.1.529 lineages.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Investigators assessed the impact of HIV infection on the quality and epitope specificity of SARS-CoV-2 T cell responses in the first wave and second wave of the COVID-19 epidemic in South Africa.
[eLife] |
| | MORE IMMUNOLOGY OF INFECTIOUS DISEASE |
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| Scientists demonstrated a strategy of “albumin hitchhiking” to promote mucosal immunity using an intranasal vaccine consisting of protein immunogens modified with an amphiphilic albumin-binding polymer-lipid tail, forming amph-proteins.
[Science Translational Medicine] |
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| The authors developed a clade C HIV-1 vaccine consisting of priming with modified vaccinia Ankara and boosting with cyclically permuted trimeric gp120 protein, delivered either orally using a needle-free injector or through parenteral injection.
[Science Immunology] |
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| Researchers elucidated the mechanisms by which TREM2 macrophages and unsaturated lipids, similar to their involvement in atherosclerosis, may have contributed to the pathogenesis of acne.
[Science Immunology] |
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| Scientists found that Epstein-Barr virus nuclear antigen 2 (EBNA2) exploited early B cell factor 1 (EBF1) to support key metabolic processes and to foster cell cycle progression of infected B cells in their first cell cycles upon activation.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Investigators analyzed the blood samples collected longitudinally in a community-based study and covered the first wave of pandemic H1N1, two subsequent pH1N1 epidemics, and three seasonal H3N2 influenza A epidemics for which they measured pre-existing influenza virus-specific CD4 and CD8 T cell responses.
[BMC Medicine] |
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| Researchers investigated whether Campylobacter jejuni induced differentiation of human neutrophils into the hypersegmented, CD16hi/CD62Llo subtype.
[Journal of Leukocyte Biology] |
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| The authors discuss immune evasion and provocation by M. tuberculosis during its infection cycle and describe how a more detailed molecular understanding is crucial to enable the development of novel host-directed therapies, disease biomarkers and effective vaccines.
[Nature Reviews Microbiology] |
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| Scientists outline the neuropathogenesis of HIV, from initial HIV entry into the central nervous system to chronic infection, focusing on key advancements in the last five years.
[Seminars in Immunopathology] |
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| OpGen, Inc. announced that its subsidiary Ares Genetics GmbH and the Belgian National Reference Centre for invasive S. pneumoniae at the Universitair Ziekenhuis Leuven (UZ Leuven) have entered into a collaboration agreement.
[OpGen, Inc.] |
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| Cidara Therapeutics, Inc. announced that it has submitted a New Drug Application (NDA) to the US FDA for rezafungin for the treatment of candidemia and invasive candidiasis.
[Cidara Therapeutics, Inc.] |
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| The World Health Organization (WHO) declared the global spread of monkeypox a Public Health Emergency of International Concern, even though a special advisory committee again declined to recommend the action.
[ScienceInsider] |
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| Aug 7-12, 2022
Saxtons River, Vermont, United States |
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| | University of Wisconsin-Madison – Madison, Wisconsin, United States |
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| | Gilead Sciences, Inc. – Foster City, California, United States |
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| | Wellcome Sanger Institute – Cambridge, England, United Kingdom |
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| | The Chinese University of Hong Kong – Hong Kong, China |
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| | Boehringer Ingelheim – Vienna, Austria |
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