 | | Vol. 8.33 – 9 September, 2022 |
| |
|
|
| Researchers reported that intestinal epithelial cell Sirtuin 6 deletion led to impaired tuft cell development and type 2 immunity in response to helminth infection, thereby resulting in compromised worm expulsion.
[Nature Communications] |
|
|
|
 | | PUBLICATIONSRanked by the impact factor of the journal |
|
|
|
| Investigators revealed the essential roles of ALCAM and PROM1, as well as their upstream regulators, the cAMP/PKA/CREB and TGF-β/SMAD4 pathways, in maintaining the stemness and metastatic potential of colorectal cancer cells.
[Cancer Research] |
|
|
|
| Through next generation sequencing, scientists identified microtubule-associated protein 7 domain 2 (MAP7D2) as an exploitable therapeutic maneuver to improve the efficacy of immune checkpoint inhibitors for microsatellite stable colorectal cancer therapy.
[Molecular Therapy] |
|
|
|
| Cytoplasmic polyadenylation element-binding protein 3 (CPEB3) suppressed gastric cancer cell proliferation, invasion and migration in vitro, as well as tumor growth and metastasis in vivo.
[Oncogene] |
|
|
|
| The authors presented a new in vitro model of the small intestine based on primary epithelial cells, apically accessible, with native tissue mechanical properties and controlled mesh size, 3D villus-like architecture, and precisely controlled biomolecular gradients of the intestinal stem cell niche.
[Advanced Healthcare Materials] |
|
|
|
| Researchers investigated the mechanistic advantages of MIR143-3p in various KRAS mutant colorectal cancer cell lines.
[Molecular Therapy-Nucleic Acids] |
|
|
|
| The 3D extracellular matrix could mediate cytoskeletal F-actin bundling through biomechanical force associated receptors integrin β1, contributing to the release of E3 ligase Tripartite motif protein 11 from cytoskeleton and degradation of the glycolytic rate-limiting enzyme phosphofructokinase.
[Cancer Science] |
|
|
|
| Overexpressed monocyte chemotactic protein-induced protein 1 (MCPIP1) was found to inhibit the proliferative and migratory abilities of colorectal cancer cells, whereas knockdown of MCPIP1 produced the opposite result.
[Cancer Gene Therapy] |
|
|
|
| Scientists showed that transmissible gastroenteritis virus infection initiated interferon and inflammatory responses following the loss of absorptive enterocytes and goblet cells, but did not disturb epithelial integrity but induced the proliferation of intestinal stem cells.
[Journal of Virology] |
|
|
|
| Investigators explored the antiproliferative, pro-apoptotic, and oxidative stress potentials of resveratrol-Zein nanoparticles versus resveratrol against human colorectal carcinoma HCT-116 cells.
[Scientific Reports] |
|
|
|
|
| The authors summarize the already known roles and mechanisms of action of the anterior gradient family proteins in digestive diseases, their expression in the healthy digestive tract, and in digestive oncology.
[Oncogene] |
|
|
|
|
| OncXerna Therapeutics, Inc. announced the initiation of dosing in a Phase II basket trial evaluating the anti-DLL4/VEGF bispecific antibody navicixizumab, alone or in combination with chemotherapy, in patients with select advanced solid tumors.
[OncXerna Therapeutics, Inc.] |
|
|
|
|
| December 4 – 7, 2022
Banff, Alberta, Canada |
|
|
|
|
|
| | Columbia University – New York, New York, United States |
|
|
|
| | Beckman Research Institute of City of Hope – Duarte, California, United States |
|
|
|
| | STEMCELL Technologies, Inc. – Vancouver, British Columbia, Canada |
|
|
|
| | Technical University of Denmark – Lyngby, Denmark |
|
|
|
| | Michigan State University – East Lansing, Michigan, United States |
|
|
|
|
Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
