Muscle Cell News Volume 7.15 | May 2 2022

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    2022-05-02 | MUSCN 7.15


    Muscle Cell News by STEMCELL Technologies
    Vol. 7.15 – 2 May, 2022
    TOP STORY

    Exercise Causes Arrhythmogenic Remodeling of Intracellular Calcium Dynamics in Plakophilin-2-Deficient Hearts

    Scientists suggested that membrane-permeable β-blockers were potentially more efficient for patients with arrhythmogenic right ventricular cardiomyopathy, and highlighted the potential for ryanodine receptor 2 channel blockers as treatment for the control of heart rhythm in the population at risk.
    [Circulation]

    Abstract
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    PUBLICATIONSRanked by the impact factor of the journal

    Metabolically Driven Maturation of Human-Induced-Pluripotent-Stem-Cell-Derived Cardiac Microtissues on Microfluidic Chips

    The authors showed that suitable combinations of mechanical stimuli and metabolic cues could enhance the maturation of human iPSC-derived cardiomyocytes, and that the maturation-inducing cues had phenotype-dependent effects on the cells’ action-potential morphology and calcium handling.
    [Nature Biomedical Engineering]

    Abstract

    Targeting McOln1/TRPML1 Channels to Protect against Ischemia-Reperfusion Injury by Restoring the Inhibited Autophagic Flux in Cardiomyocytes

    Investigators revealed that MCOLN1/TRPML1, a lysosomal cationic channel, directly contributed to the inhibition of autophagic flux in cardiomyocytes post ischemia-reperfusion.
    [Autophagy]

    Abstract

    GCN5-Mediated Regulation of Pathological Cardiac Hypertrophy via Activation of the TAK1-JNK/p38 Signaling Pathway

    Researchers explored the role of general control nonrepressed protein 5 (GCN5) in the development of pathological cardiac hypertrophy. GCN5 expression was increased in isolated neonatal rat cardiomyocytes and mouse hearts of a hypertrophic mouse model.
    [Cell Death & Disease]

    Full Article

    MicroRNAs Signatures as Potential Biomarkers of Structural Cardiotoxicity in Human-Induced Pluripotent Stem-Cell Derived Cardiomyocyte

    Scientists investigated the expression of microRNAs in human-induced pluripotent stem cell cardiomyocytes in response to a broad range of cardiotoxic drugs.
    [Archives of Toxicology]

    Abstract

    Isoorientin Attenuates Doxorubicin-Induced Cardiac Injury via the Activation of MAPK, Akt, and Caspase-Dependent Signaling Pathways

    The authors investigated the effect and mechanism of the natural flavonoid isoorientin combined with doxorubicin (DOX) on the proliferation of tumor cells and improve the survival rate of DOX-injured cardiomyocytes.
    [Phytomedicine]

    AbstractGraphical Abstract

    Verapamil Down-Regulates Iron Uptake and Up-Regulates Divalent Metal Transporter 1 Expression in H9C2 Cardiomyocytes

    Scientists investigated the effects of the L-type voltage-dependent Ca2+ channel blocker verapamil on non-transferrin-bound iron uptake as well as divalent metal transport 1 expression in H9C2 cells by the measurement of radio-labeled 55Fe(II), RT-PCR and western blot analysis.
    [Fundamental & Clinical Pharmacology]

    Abstract

    Disturbance of Calcium Homeostasis and Myogenesis Caused by TET2 Deletion in Muscle Stem Cells

    Researchers observed that ten-eleven translocation-2 (TET2) deficiency caused impaired muscle stem cell proliferation and differentiation, resulting in the reduction in both myofiber number and muscle tissue size.
    [Cell Death Discovery]

    Full Article

    Substitution of SERCA2 Cys674 Accelerates Aortic Aneurysm by Inducing Endoplasmic Reticulum Stress and Promoting Cell Apoptosis

    Cultured aortic smooth muscle cells (SMCs) were used for protein expression, apoptosis analysis and cell function studies. The irreversible oxidation of sarcoplasmic/endoplasmic reticulum Ca2+ ATPase 2 (SERCA2) C674 promoted the development of aortic aneurysm by inducing endoplasmic reticulum stress and subsequent SMC apoptosis.
    [British Journal of Pharmacology]

    Abstract

    A Collagen-Derived Oligopeptide from Salmo Salar Collagen Hydrolysates Restrains Atherogenesis in ApoE–/– Mice via Targeting P2Y12 Receptor

    In vitro study suggested that OG-5 inhibited the release of inflammatory cytokines in endothelial cells and macrophage cells, migration of vascular smooth muscle cell induced by ADP, which was highly released in ApoE–/– mice
    [Molecular Nutrition & Food Research]

    Abstract

    Circ_CSNK1E Modulates Airway Smooth Muscle Cells Proliferation and Migration via miR-34a-5p/VAMP2 Axis in Asthma

    Researchers investigated the regulatory role and mechanism of circ_CSNK1E in airway smooth muscle cells proliferation and migration.
    [Cellular Signalling]

    Abstract

    Circular RNA circ_0002594 Regulates PDGF-BB-Induced Proliferation and Migration of Human Airway Smooth Muscle Cells via Sponging miR-139-5p/TRIM8 in Asthma

    Scientists explored the role and mechanism of circ_0002594 in human airway smooth muscle cells proliferation and metastasis.
    [Autoimmunity]

    Abstract
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    REVIEWS

    Stressed Out – The Role of Oxidative Stress in Airway Smooth Muscle Dysfunction in Asthma and COPD

    Investigators provide a thorough review of studies that have used primary airway, bronchial or tracheal smooth muscle cells to investigate the role of oxidative stress/ROS in airway smooth muscle dysfunction.
    [Free Radical Biology and Medicine]

    Full ArticleGraphical Abstract

    Sarcoplasmic Reticulum Ca2+ Dysregulation in the Pathophysiology of Inherited Arrhythmia: An Update

    The authors summarize normal sarcoplasmic reticulum (SR) Ca2+ regulation in cardiomyocytes, mechanisms of how Ca2+ triggers arrhythmias and involvements of SR gene mutations in inherited arrhythmias as well as the possible arrhythmogenic effects of these mutations.
    [Biochemical Pharmacology]

    AbstractGraphical Abstract
    INDUSTRY AND POLICY NEWS

    Ultomiris Approved in the US for Adults with Generalised Myasthenia Gravis

    Ultomiris has been approved in the US for the treatment of adult patients with generalized myasthenia gravis who are anti-acetylcholine receptor antibody-positive, which represents 80% of people living with the disease.
    [AstraZeneca plc]

    Press Release
    FEATURED EVENT

    Cell UK

    November 7 – 8, 2022
    London, England, United Kingdom

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    JOB OPPORTUNITIES

    Postdoctoral Position – 3D Model Development

    Novo Nordisk – Måløv, Denmark

    Postdoctoral Fellows – Heart and Muscle Disease

    Duke University – Durham, North Carolina, United States

    Research Scientist – Cell Line Development

    Shiok Meats Pte Ltd – Singapore, Singapore

    Laboratory Technician – iPSC and Organoid Maintenance

    Harvard University – Cambridge, Massachusetts, United States

    Postdoctoral Fellows – Molecular Cardiology

    University of California, San Diego – La Jolla, California, United States

    > See All Jobs

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