Muscle Cell News Volume 7.29 | Aug 22 2022

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    2022-08-22 | MUSCN 7.29


    Muscle Cell News by STEMCELL Technologies
    Vol. 7.29 – 22 August, 2022
    TOP STORY

    High-Efficiency Quantitative Control of Mitochondrial Transfer Based on Droplet Microfluidics and Its Application on Muscle Regeneration

    The authors developed a droplet microfluidics–based mitochondrial transfer technique that could achieve high-efficiency and high-throughput quantitative mitochondrial transfer to single cells.
    [Science Advances]

    Full Article
    Explore Antibodies for Epithelial Cell Markers
    PUBLICATIONSRanked by the impact factor of the journal

    Single-Cell Transcriptomic Profiling Unveils Dysregulation of Cardiac Progenitor Cells and Cardiomyocytes in a Mouse Model of Maternal Hyperglycemia

    Researchers established a murine model of pregestational diabetes to uncover the transcriptional responses in key cell-types of the developing heart exposed to maternal hyperglycemia.
    [Communications Biology]

    Full Article

    A Perinuclear Calcium Compartment Regulates Cardiac Myocyte Hypertrophy

    Scientists demonstrated the existence of a functionally independent calcium signaling compartment in the cardiac myocyte regulating hypertrophy and provided a premise for targeting mAKAPβ signalosomes to prevent selectively cardiac hypertrophy in disease.
    [Journal of Molecular and Cellular Cardiology]

    Full ArticleGraphical Abstract

    SRF-Derived miR210 and miR30c Both Repress Beating Cardiomyocyte Formation in the Differentiation System of Embryoid Body

    Investigators found that serum response factor (SRF) directly controlled the cardiac expression of miR210.
    [Biochemical and Biophysical Research Communications]

    Abstract

    Ectopic Acsl6 Overexpression Partially Improves Isoproterenol (ISO)-Induced Cardiac Hypertrophy In Vivo and Cardiomyocyte Hypertrophy In Vitro

    In vitro, Acsl6 overexpression partially attenuated ISO-induced cardiomyocyte hypertrophy and increases in hypertrophic markers.
    [Journal of Cardiovascular Pharmacology]

    Full Article

    Epigenetic Modification Mechanism of Histone Demethylase KDM1A in Regulating Cardiomyocyte Apoptosis After Myocardial Ischemia-Reperfusion Injury

    Researchers investigated the mechanism of the lysine-specific histone demethylase 1A (KDM1A) on cardiomyocyte apoptosis after myocardial ischemia-reperfusion injury.
    [Peerj]

    Full Article

    The NLRP3 Inflammasome Contributes to Inflammation-Induced Morphological and Metabolic Alterations in Skeletal Muscle

    Differentiated C2C12 myotubes were treated with lipopolysaccharide to induce activation of the nucleotide-binding oligomerization domain-like receptor family pyrin domain containing 3 (NLRP3) inflammasome with and without MCC950, a pharmacological inhibitor of NLRP3-induced IL-1β production.
    [Journal of Cachexia Sarcopenia and Muscle]

    Full ArticleGraphical Abstract

    Obesity Impairs Skeletal Muscle Repair Through NID-1 Mediated Extracellular Matrix Remodeling by Mesenchymal Progenitors

    Scientists identified NID-1 among the adipose tissue secreted factors impairing myogenic potential of human myoblasts and murine muscle stem cells in vitro.
    [Matrix Biology]

    AbstractGraphical Abstract

    The Role of the Aging Microenvironment on the Fate of PDGFRβ Lineage Cells in Skeletal Muscle Repair

    Researchers investigated the role of platelet-derived growth factor receptors β (PDGFRβ) lineage cells in skeletal muscle during aging by using Cre/loxP lineage tracing technology.
    [Stem Cell Research & Therapy]

    Full Article

    Cellular Mechanisms of Oligoclonal Vascular Smooth Muscle Cell Expansion in Cardiovascular Disease

    The authors investigated the dynamics of vascular smooth muscle cells (VSMCs) clone formation using confocal microscopy and single cell transcriptomics in VSMC-lineage-traced animal models.
    [Cardiovascular Research]

    Abstract
    Graphical Abstract

    The Role of Gap Junctions in the Generation of Smooth Muscle Cells from Bone Marrow Mesenchymal Stem Cells

    Rat bone marrow mesenchymal stem cells and smooth muscle cell were obtained from the bone marrow and bladder of Sprague-Dawley rats, respectively. Flow cytometry and multilineage differentiation were performed to assess the characteristics of these cells.
    [Disease Markers]

    Full Article
    How to prioritize and manage your research projects
    REVIEWS

    The Negative Regulation of Gene Expression by MicroRNAs as Key Driver of Inducers and Repressors of Cardiomyocyte Differentiation

    Scientists reviewed the mechanisms of cardiomyocyte (CM) differentiation during development and from regenerative stem cells with a focus on the involvement of microRNAs in the process, putting in perspective their negative gene regulation as a main modifier of effective CM regeneration in the adult heart.
    [Clinical Science]

    Full Article
    INDUSTRY AND POLICY NEWS

    USask Researchers Studying Zebrafish to Get to the Heart of Your Heartbeat

    Dr. Michelle Collins was recently awarded a Natural Sciences and Engineering Research Council of Canada Discovery Grant of $185,000 over five years to pursue the deeper question of how calcium moves through the cell and what controls that flux.
    [University of Saskatchewan]

    Press Release

    Zhang and Colleagues Win an $11.2 Million NIH Program Project Grant (PPG)

    The National Institutes of Health (NIH) has awarded a five-year, $11.2 million to Dr. Jianyi “Jay” Zhang and colleagues to study how to restore the dead tissue from a heart attack, through the growth of new heart muscle cells.
    [University of Alabama at Birmingham]

    Press Release
    FEATURED EVENT

    Stem Cells: Advances in the Application of Stem Cells and Their Role In Vivo

    February 5 – 8, 2022
    Keystone, Colorado, United States

    > See All Events

    JOB OPPORTUNITIES

    Research Associate – Cardiac Sciences

    University of British Columbia – Vancouver, British Columbia, Canada

    Research Associates – Center for Perioperative Organ Protection

    Duke University – Durham, North Carolina, United States

    Postdoctoral Fellowship – Translational Cardiovascular Medicine

    University of Alberta – Edmonton, Alberta, Canada

    Research Associate/Group Leader – Tissue Engineering

    Darmstadt University of Technology – Darmstadt, Germany

    Research Scientist – Cardiovascular & Heart Research

    Nationwide Children’s Hospital – Columbus, Ohio, United States

    > See All Jobs

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